エレトリプタン
エレトリプタン 物理性質
- 融点 :
- 168-170?C
- 沸点 :
- 613.4±55.0 °C(Predicted)
- 比重(密度) :
- 1.235±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- DMSO（微量）、メタノール（微量）
- 酸解離定数(Pka):
- 17.14±0.30(Predicted)
- 外見 :
- 個体
- 色:
- 淡い黄色から濃い黄色
- 安定性：:
- 吸湿性
- InChI:
- InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1
- InChIKey:
- PWVXXGRKLHYWKM-LJQANCHMSA-N
- SMILES:
- N1C2=C(C=C(CCS(C3=CC=CC=C3)(=O)=O)C=C2)C(C[C@H]2CCCN2C)=C1
- CAS データベース:
- 143322-58-1(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
エレトリプタン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
エレトリプタン 化学特性,用途語,生産方法
効能
抗片頭痛薬, 血管収縮薬, セロトニン受容体作動薬
化学的特性
Yellow Foam
使用
Eletriptan is a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines (1,2,3).
定義
ChEBI: Eletriptan is an N-alkylpyrrolidine, being N-methylpyrrolidine in which the pro-R hydrogen at position 2 is substituted by a {5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-yl}m
thyl group.
一般的な説明
Eletriptan, introduced into the market in 2002, is the newesttriptan with highest affinity for 5-HT1B, 5-HT
1D, and 5-HT
1Freceptors. It is one of the most lipophilic triptans marketedto date and is well tolerated and safe across its dosing rangeof 20 to 80 mg. However, it is metabolized primarily(>90%) by CYP3A4 isozyme to its active metabolite, theN-desmethyleletriptan, which accounts for approximately10% to 20% of the plasma concentration of that observedfor parent drug. Thus, coadministration of eletriptan withpotent CYP3A4 inhibitors such as ketoconazole, itraconazole,nefazodone, troleandomycin, clarithromycin, ritonavir,and nelfinavir may require dose reduction and closer monitoringfor CNS side effects. Furthermore, becauseeletriptan and its active metabolite, N-desmethyleletriptan,are also substrates for the P-glycoprotein efflux pumps thatare responsible for their removal from the brain, coadministrationof eletriptan with a known P-glycoprotein inhibitorand/or inducer such as digoxin, diltiazem, verapamil, or St.John’s Worth would result in higher brain levels of its activemetabolite, and thus a higher rate of the CNS side effectsreported for this drug.
エレトリプタン 上流と下流の製品情報
原材料
準備製品
エレトリプタン 生産企業
Global( 137)Suppliers
143322-58-1(エレトリプタン)キーワード:
- 143322-58-1
- (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-Indole
- (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole
- Eletriptan
Also see: R143400
- Eletriptan Free Base
- Relpax free aMine
- 3-benzyl-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)-1,2,4-oxadiazole
- 5-[2-(benzenesulfonyl)ethyl]-3-{[(2R)-1-Methylpyrrolidin-2-yl]Methyl}-1H-indole
- 1H-Indole,3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethyl]-
- According to triptans
- 5-[2-(benzenesulfonyl)ethyl]-3-[1-methylpyrrolidin-2(R)-ylmethy] -1H-indole
- (R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole
- ELETRIPTAN
- 3-[(1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole
- 5-(2-(Benzenesulfoyl)vinyl)-3-(1-Methylpyrrolidin-2(R)-ylmethyl)-1H-Indole
- EletriptanHydrobromide(ForR&DOnly)
- UK-116044,Relpax,3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole
- 5-(2-(BENZENESULFONYL)VINYL)-3-(1-METHYLPYRROLIDIN-2(R)-YLMETHYL)-1H-INDOLE
- 3-[[(R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]indolemonohydrobromide
- 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole
- UK-116044
- 1H-Indole, 3-(((2R)-1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)ethyl)-
- Unii-22qoo9B8ki
- (R)-Eletriptan
- Eletriptan USP/EP/BP
- Tianfu Chem Eletriptan
- Eletriptan
(UK 116044)
- 5-[2-(benzenesulfonyl)ethyl]-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
- Eletriptan Impurity 6
- 5-[2-(benzenesulfonyl)ethyl]-3-[(1-Methylpyrrolidin-2-yl)Methyl]-1H-indole
- Relpax
- エレトリプタン
- 3-[[(2R)-1-メチル-2-ピロリジニル]メチル]-5-[2-(フェニルスルホニル)エチル]-1H-インドール
- 5-[2-(ベンゼンスルホニル)エチル]-3-{[(2R)-1-メチルピロリジン-2-イル]メチル}-1H-インドール
- 3-[[(2R)-1-メチルピロリジン-2-イル]メチル]-5-[2-(フェニルスルホニル)エチル]-1H-インドール