1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン

1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン 価格 もっと(6)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01BVI1767-5	PP2	172889-27-9	5mg	￥100100	2020-09-21	購入
富士フイルム和光純薬株式会社(wako)	W01BVI1767-1	PP2	172889-27-9	1mg	￥26000	2020-09-21	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1407	PP2 PP 2	172889-27-9	10mg	￥101000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MAS096440	1-(tert-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-d]ピリミジン-4-アミン 1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	172889-27-9	250mg	￥1043300	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MAS096440	1-(tert-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-d]ピリミジン-4-アミン 1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	172889-27-9	1g	￥2318400	2024-03-01	購入

1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン 化学特性,用途語,生産方法

外観

結晶～粉末

溶解性

メタノール､DMSOに溶ける。

用途

チロシンキナーゼの研究。

説明

The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), Hck (IC₅₀ = 5 nM), and Src (IC₅₀ = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC₅₀ = 480 nM), JAK2 (IC₅₀ > 50 μM), or ZAP-70 (IC₅₀ > 100 μM). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr⁵⁷⁷. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC₅₀ value of 600 nM.

使用

PP2 has been used:

• to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
• for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
• for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells

生物活性

Selective inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC 50 = 0.73 μ M).

酵素阻害剤

This cell-permeable and photosensitive ATP site-directed pyrazolepyrimidine (FW = 301.78 g/mol), also known as 4-amino-5-(4- chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine and tyrphostin AG 1879, potently inhibits Lck and Fyn protein kinases, with IC50 values of 4 nM and 5 nM. PP2 is ~100x less potent toward EGFR and is inactive for ZAP-70, JAK2 and PKA. PP2 prevented serum-independent growth of RET/PTC1-transformed NIH3T3 fibroblasts and of TPC1 and FB2, two human papillary thyroid carcinoma cell lines that carry spontaneous RET/PTC1 rearrangements. PP2 activates the E-cadherin-mediated cell adhesion system, suppressing metastasis in cancer cells. In cervical cancer cells (HeLa and SiHa), 10 μM PP2 down-regulates pSrc-Y416, pEGFR-Y845, and pEGFR-Y1173 expression levels, while downregulatING pSrc-Y416 and pEGFR-Y845, but not pEGFR-Y1173. PP2 is also a potential neuroprotective agent in cerebral ischemia-reperfusion. Target(s): casein kinase 1d, IC50 = 1.3 μM; Csk protein-tyrosine kinase; focal adhesion kinase; lymphocyte kinase, IC50 = 0.06 μM; p56lck, IC50 = 4 nM; p59fynT, IC50 = 5 nM; receptor proteintyrosine kinase; src protein-tyrosine kinase, IC50 = 0.7 μM (5,11,12- 23); stress-activated protein kinase 2a/p38, IC50 = 1.4 μM; and Yes kinase.

1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン 上流と下流の製品情報

原材料

準備製品

1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

172889-27-9(1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン)キーワード:

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• 172889-27-9
• [1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]amine
• 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine
• PP2(AG 1879)
• AGL 1879
• PP 2 (enzyme inhibitor)
• Src kinase inhibitor PP2
• 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-
• AG 1879,AGL 1879
• 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine AGL 1879
• 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine
• PP2;AGL 1879;PP 2;PP-2
• 1-(TERT-BUTYL)-3-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
• 1-(TERT-BUTYL)-3-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
• 3-(4-CHLOROPHENYL) 1-(1,1-DIMETHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
• 4-AMINO-5-(4-CHLOROPHENYL)-7-(T-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE
• 4-AMINO-5-(4-CHLOROPHENYL)-7-(TERT-BUTYL)PYRAZOLO[3,4-D]PYRIMIDINE
• AG 1879
• 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-(1H)-pyrazolo[3.4-d]pyrimidine-4-amine
• PP2
• PP 2;AG1879;AG 1879;AGL 1879
• PP2(AGL 1879)
• CS-717
• 7-tert-butyl-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Src family kinase inhibitor PP2
• 1-(TERT-ブチル)-3-(4-クロロフェニル)-1H-ピラゾロ[3,4-D]ピリミジン-4-アミン
• PP2