ヘキセチジン 化学特性,用途語,生産方法
効能
消毒薬
化学的特性
Hexetidine is a colorless or faint yellow-colored oily liquid with a
characteristic amine odor.
使用
Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.
調製方法
Hexetidine is prepared by hydrogenation under pressure of 1,3-
bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C
using Raney nickel as a catalyst.
一般的な説明
The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.
危険性
Combustible.
応用例（製薬）
Hexetidine is used as an antimicrobial preservative in cosmetics and
nonparenteral pharmaceutical formulations. Therapeutically, hexetidine
is mainly used as a 0.1% w/v solution in mouthwash
formulations for the prevention and treatment of minor local
infections, gingivitis, and mouth ulcers.
安全性
Hexetidine is mainly used in mouthwashes as a bactericidal and
fungicidal antiseptic. It is also used as an antimicrobial preservative
and is generally regarded as a relatively nontoxic and nonirritant
material at concentrations up to 0.1% w/v. Allergic contact
dermatitis and altered olfactory and taste perception have
occasionally been reported. Hexetidine is toxic when administered
intravenously.
Solutions of hexetidine in oil at concentrations of 5–10% w/v
cause strong primary irritations without sensitization in humans.
Long-term toxicological studies of up to 0.1% w/w of hexetidine in
food for 1 year do not show any toxic effect. Fetotoxicity,
embryotoxicity, and teratogenicity studies in rats of doses up to
50 mg/kg/day exhibit no sign of toxicity.
LD100 (cat, IV): 5–20 mg/kg
LD50 (dog, oral): 1.60 g/kg
LD50 (mouse, IP): 0.142 g/kg
LD50 (mouse, oral): 1.52 g/kg
LD50 (rat, oral): 0.61–1.43 g/kg
貯蔵
Hexetidine is stable and should be stored in a well-closed container
in a cool, dry place. Brass and copper equipment should not be used
for the handling or storage of hexetidine.
不和合性
Hexetidine is incompatible with strong oxidizing agents. Salts are
formed with mineral and organic acids; strong acids cause opening
of the hexahydropyrimidine ring, releasing formaldehyde.
規制状況(Regulatory Status)
Included in nonparenteral formulations licensed in Europe.
ヘキセチジン 上流と下流の製品情報
原材料
準備製品