3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 物理性質
- 貯蔵温度 :
- −20°C
- 溶解性:
- H2O: 6.3 mg/mL
- 外見 :
- 個体
- 色:
- 白い
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xn |
|
|
| Rフレーズ |
22 |
|
|
| Sフレーズ |
26-36 |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番号 |
YM3055500 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P330 |
口をすすぐこと。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
|
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC0917 |
3α-[(4-Chlorophenyl)phenylmethoxy] tropane hydrochloride |
14008-79-8 |
10mg |
￥17000 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC0917 |
3α-[(4-Chlorophenyl)phenylmethoxy] tropane hydrochloride |
14008-79-8 |
50mg |
￥63000 |
2018-12-26 |
購入 |
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 化学特性,用途語,生産方法
Originator
Clobenztropine,Onbio Inc.
Manufacturing Process
A solution of 28.2 g (0.2 mol) of 3-tropanol is prepared in 50 ml of xylol, and
to this solution is added 23.8 g (0.1 mol) of 4-chlorobenzhydryl chloride. The
resultant solution is heated for 7 h at 145°-155°C, following which the
mixture is cooled and filtered. The clear filtrate thus obtained is washed with
50 ml of 5% aqueous potassium carbonate solution and then with three
successive 25 ml portion of water. The xylol solution is then extracted with
three successive 50 ml portions of 2 N hydrochloric acid. The xylol layer is
discarded and the acid extracts are combined and rendered strongly basic by
the addition of 22.5% aqueous potassium hydroxide, resulting in the
formation of an oily base which separates and which is then extracted with
benzol, from which the benzol is evaporated to yield crude 3-(4'-
chlorobenzhydryloxy)tropane as a brown oil.
2.0 g of 3-(4'-chlorobenzhydryloxy)tropane is treated with 10 ml of 4.5 N
isopropanoic acid hydrogen chloride solution, and the pasty mixture which
results is diluted with approximately 30 ml of absolute ether. A solid product is
formed which is separated by filtration and then washed with absolute ether.
The product is then purified by dissolving it in hot isopropanol, followed by
clarification with activated charcoal. Upon cooling the filtrate, the 3-(4'-
chlorophenylbenzyloxy)tropane separates as a crystalline powder, melting
point 215°-217°C.
In practice it is usually used as hydrochloride.
Therapeutic Function
Antihistaminic
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 上流と下流の製品情報
原材料
準備製品
3-ALPHA-[(4-CHLOROPHENYL)PHENYLMETHOXY] TROPANE HYDROCHLORIDE 生産企業
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