グリチルリチン酸 モノアンモニウム 化学特性,用途語,生産方法
外観
白色の粉末
定義
本品は、グリチルリチン酸(*)のアンモニウム塩である。参照表示名称：グリチルリチン酸
溶解性
水に難溶。エタノール可溶。
用途
食品中のグリチルリチン酸定性用標準品。
化粧品の成分用途
皮膚コンディショニング剤、香料、香味剤
効能
抗炎症薬
説明
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground
rhizome and root portions of Glycyrrhiza glabra or other species of
glycyrrhiza. Licorice extract is that portion of the licorice root that
is, after maceration, extracted by boiling water. The extract can be
further purified by filtration and by treatment with acids and ethyl
alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried
powder. (2) Ammoniated glycyrrhizin is prepared from the
water extract of licorice root by acid precipitation followed by neutralization
with dilute ammonia. Monoammonium glycyrrhizinate
(C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by
solvent extraction and separation techniques.
化学的特性
white to slightly yellow powder
使用
Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
一般的な説明
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
抗がん研究
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
安全性プロファイル
Moderately toxic by
intravenous route. An experimental
teratogen. Experimental reproductive
effects. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NH3.
純化方法
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]
グリチルリチン酸 モノアンモニウム 上流と下流の製品情報
原材料
準備製品