SB203580
SB203580 物理性質
- 融点 :
- 144-146
- 沸点 :
- 615.6±55.0 °C(Predicted)
- 比重(密度) :
- 1.4
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO: 50 mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- 9.60±0.10(Predicted)
- 色:
- ホワイトからオフホワイト
- 安定性::
- -200℃
- InChIKey:
- CDMGBJANTYXAIV-UHFFFAOYSA-N
- CAS データベース:
- 152121-47-6(CAS DataBase Reference)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLCM02481 |
SB-203580 |
152121-47-6 |
50mg |
¥138100 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01FLCM02481 |
SB-203580 |
152121-47-6 |
250mg |
¥213100 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01CAY13067 |
SB 203580 |
152121-47-6 |
50mg |
¥93800 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
S8307 |
solid, ≥98% (HPLC)
SB 203580 solid, ≥98% (HPLC) |
152121-47-6 |
1mg |
¥52100 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01W0119-1655 |
98.0+% (HPLC)
SB203580 98.0+% (HPLC) |
152121-47-6 |
1mg |
¥24200 |
2024-03-01 |
購入 |
SB203580 化学特性,用途語,生産方法
外観
白色~うすい黄褐色、結晶~粉末
溶解性
メタノールに溶ける。
化学的特性
White to Off-White Solid
使用
MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.
16 It was used to inhibit MAPK signaling in mouse cortical neurons
17 and human hepatocellular carcinoma cell lines.
18
定義
ChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
一般的な説明
Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 kinase (IC
50 = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 μM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC
50 = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
生物活性
Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
SB203580 上流と下流の製品情報
原材料
準備製品
SB203580 生産企業
Global( 223)Suppliers
152121-47-6(SB203580)キーワード:
- 152121-47-6
- SB 203580 HYDROCHLORIDE
- SB 2035850
- 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE
- 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL
- 4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE
- 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE
- 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE
- 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine
- 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine
- PB 203580
- Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-
- 4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole
- SB 203580, >=98%
- 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB 203580
- SB 203580 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
- RWJ 64809
- RWJ 64809; PB 203580
- SB 203580
- MAPK inhibitor (SB 203580)
- SB203580(RWJ 64809)
- SB 203580 - CAS 152121-47-6 - Calbiochem
- SB203580;SB 203580
- SB203580 (RWJ 64809, PB 203580)
- CS-42
- RWJ 64809;PB 203580;SB203580;SB-203580
- SB SB
- SB 203580USP/EP/BP
- SB 203580 hydrochlor
- Adezmapimod
- SB 203580, ≥98% (HPLC)
- SB203580
- EZSOLUTION™ SB 203580
- SB 203580
- 4-(4-フルオロフェニル)-2-[4-(メチルスルフィニル)フェニル]-5-(4-ピリジル)-1H-イミダゾール
- 2-[4-(メチルスルフィニル)フェニル]-4-(4-フルオロフェニル)-5-(4-ピリジニル)-1H-イミダゾール
- 4-[5-(4-フルオロフェニル)-2-[4-(メチルスルフィニル)フェニル]-1H-イミダゾール-4-イル]ピリジン
- 4-[4-(4-フルオロフェニル)-2-(4-メタンスルフィニルフェニル)-1H-イミダゾール-5-イル]ピリジン
- メチル[4-[4-(4-フルオロフェニル)-5-(4-ピリジニル)-1H-イミダゾール-2-イル]フェニル]スルホキシド
- SB-203580
- 2-[4-(メチルスルフィニル)フェニル]-4-(4-ピリジル)-5-(4-フルオロフェニル)-1H-イミダゾール
- 2-[4-(メチルスルフィニル)フェニル]-4-(4-フルオロフェニル)-5-(4-ピリジル)-1H-イミダゾール