2-(4-チアゾリル)ベンゾイミダゾール

2-(4-チアゾリル)ベンゾイミダゾール 化学構造式
148-79-8
CAS番号.
148-79-8
化学名:
2-(4-チアゾリル)ベンゾイミダゾール
别名:
2-(4-チアゾリル)ベンゾイミダゾール;チアベンダゾール;チアベンダゾ-ル(農薬用);チアベンダゾール標準品;チアベンダゾル;2-(1・3-チアゾール-4-イル)-1H-ベンゾイミダゾール;チアベンダゾール(TBZ);2-(4'-チアゾリル)ベンズイミダゾール;2-(1,3-チアゾール-4-イル)-1H-ベンゾイミダゾール;2‐(1,3‐チアゾール‐4‐イル)‐1H‐ベンゾイミダゾール;CS_N-13560-250MG_チアベンダゾールTBZ;チアベンダゾール IN METHANOL;チアベンダゾール標準物質;チアベンダゾール, 0.1 mg/mL in Acetonitrile;チアベンダゾール, 100 µg/mL in MeOH;チアベンダゾール (JAN);2-(1,3-チアゾール-4-イル)-1H-1,3-ベンゾジアゾール;イノキシウロール;オムニゾール;サイベンゾール散
英語名:
Thiabendazole
英語别名:
TBZ;LSP;Tiabendazole;Tiabendazol;Testo;2-(1,3-Thiazol-4-yl)benzimidazole;Mertec;Mintezol;Thiabenzole;THIABENDAZOL
CBNumber:
CB1685813
化学式:
C10H7N3S
分子量:
201.25
MOL File:
148-79-8.mol
MSDS File:
SDS

2-(4-チアゾリル)ベンゾイミダゾール 物理性質

融点 :
298-301°C
沸点 :
446.0±37.0 °C(Predicted)
比重(密度) :
1.2271 (rough estimate)
蒸気圧:
Negligible at room temperature
屈折率 :
1.5500 (estimate)
貯蔵温度 :
Sealed in dry,Room Temperature
溶解性:
メタノール、ジメチルスルホキシドに可溶。
酸解離定数(Pka):
pKa 4.7 (Uncertain)
外見 :
色:
ライトイエロー
水溶解度 :
0.005g/100mL
Merck :
14,9289
BRN :
611403
InChIKey:
WJCNZQLZVWNLKY-UHFFFAOYSA-N
LogP:
2.470
CAS データベース:
148-79-8(CAS DataBase Reference)
NISTの化学物質情報:
Thiabendazole(148-79-8)
EPAの化学物質情報:
Thiabendazole (148-79-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  N,Xi
Rフレーズ  50/53-36/37/38
Sフレーズ  60-61-36-26
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS 番号 DE0700000
TSCA  Yes
国連危険物分類  9
容器等級  III
HSコード  29341000
有毒物質データの 148-79-8(Hazardous Substances Data)
毒性 LD50 in mice, rats, rabbits (g/kg): 3.6, 3.1, >3.8 orally (Robinson)
化審法 (9)-820, (9)-1851
PRTR法 第二種指定化学物質
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 GHS hazard pictograms P273, P391, P501
注意書き
P273 環境への放出を避けること。
P501 内容物/容器を...に廃棄すること。

2-(4-チアゾリル)ベンゾイミダゾール 価格 もっと(26)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-068N チアベンダゾール
Thiabendazole
148-79-8 10mg ¥5300 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01ACSM-641 チアベンダゾール
Thiabendazole, 0.1 mg/mL in Acetonitrile
148-79-8 1mL ¥8900 2024-03-01 購入
東京化成工業 T0830 2-(4-チアゾリル)ベンゾイミダゾール >98.0%(GC)(T)
2-(4-Thiazolyl)benzimidazole >98.0%(GC)(T)
148-79-8 25g ¥5400 2024-03-01 購入
東京化成工業 T0830 2-(4-チアゾリル)ベンゾイミダゾール >98.0%(GC)(T)
2-(4-Thiazolyl)benzimidazole >98.0%(GC)(T)
148-79-8 250g ¥30600 2024-03-01 購入
関東化学株式会社(KANTO) 40650-96 チアベンダゾール標準品 >99.0%(HLC)
Thiabendazole standard >99.0%(HLC)
148-79-8 200mg ¥8500 2024-03-01 購入

2-(4-チアゾリル)ベンゾイミダゾール MSDS


2-(4-Thiazolyl)-benzimidazole

2-(4-チアゾリル)ベンゾイミダゾール 化学特性,用途語,生産方法

外観

白色~わずかにうすい褐色、結晶性粉末~粉末

溶解性

エタノール及びアセトンに溶け、水に溶けにくい。

用途

食品添加物(柑橘類の防カビ剤),駆虫剤(動物用),殺菌剤(失効農薬)

用途

動物用医薬品及び防黴剤定量用の標準品。

用途

食品等中のチアベンダゾール定量用。

効能

駆虫薬, 抗真菌薬

主な用途/役割

イミダゾール・チアゾール系抗菌剤

使用上の注意

アルゴン封入

説明

Thiabendazole is also a broad-spectrum systemic fungicide against many fungal pathogens, although this compound was originally introduced as an anthelminthic (25).

化学的特性

Light yellow powder

使用

Thiabendazole is widely used as a post-harvest systemic fungicide on citrus and bananas. It is active against fruit rots in bananas, citrus, apples and pears; bulb and corm rots in ornamentals; storage rots in sweet potato and potato and is also used to control Dutch elm disease. It is the original benzimidazole anthelmintic for both human and animal health usages.

定義

ChEBI: A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.

一般的な説明

White or cream-colored odorless, tasteless powder. Sublimes above 590°F. Fluoresces in acidic solution. Formulated as a dust, flowable powder or wettable powder for use as a systemic fungicide and anthelmintic.

空気と水の反応

Insoluble in water.

反応プロフィール

Thiabendazole is incompatible with a number of pesticides, including copper-containing fungicides, and with highly alkaline materials. Thiabendazole is a chelating agent, binding many metals including iron, but not calcium

火災危険

Flash point data for Thiabendazole are not available; however, Thiabendazole is probably combustible.

応用例(製薬)

Thiabendazole; a thiazolyl benzimidazole available for oral administration. It is active against most common intestinal nematodes. As a result of its larvicidal and ovicidal activity, it is effective in strongyloidiasis, trichinosis, visceral larva migrans and cutaneous larva migrans.
It is well absorbed from the small intestine. Peak plasma levels are reached about 1–2 h after a single oral dose of the suspension. It is extensively metabolized in the liver to the 5-hydroxy derivative, which is inactive. Most of the drug is excreted within 24 h. About 90% is excreted in the urine, chiefly as glucuronide or sulfate conjugates; the remainder is passed in the feces.
A wide range of unpleasant side effects occur, including nausea and other gastrointestinal upsets, fever and neurological effects. It has been largely replaced by the less toxic benzimidazole carbamates. Although active against Ascaris lumbricoides, E. vermicularis and hookworms, it should not be used as primary therapy for these infections.

製品名

AGROSOL? AGROSOL?T, (with thiram); APL-LUSTER? ARBOTECT? BOVIZOLE? BRODEX? CHEM-TEK? CITRUS LUSTR? DECCO SALT NO.19? E-Z-EX? EPROFIL? EQUIVET TZ? EQUIZOLE? FRESHGARD? FUNGICIDE 4 T? GRANOX? IRGAGUARD? LOMBRISTOP? MERTEC? MERTECT 160? METASOL TK-100? MINTEZOL? MINZOLUM? MK-360? MYCOZOL? NEMAPAN? NSC 525040? OMNIZOLE? POLIVAL? RIVAL? (captan + PCNB + thiabendazole); RPH? RTU-VITAVAX-EXTRA? STA-FRESH? TBZ 6? TECTO? TECTO RPH? TECTO 10P? TECTO 40 F? TESTO? THIABEN? THIABENDAZOLUM? THIABENZAZOLE? THIABENZOLE? THIBENZOL? THIBENZOLE? THIBENZOLE 200? THIBENZOLE ATT? TIABENDAZOLE? TOBAZ? TOP FORM WORMER? VITAVAX?Thiabendazole Chemical class: Benzimidazole

接触アレルゲン

This fungicide and vermifuge agent is widely used in agriculture (for example, forcitrus fruits), and in medical and veterinary practice as an anthelmintic drug.

作用機序

Thiabendazole is an antihelmintic drug with a broad spectrum of action. Although the details of its mechanism of action are not conclusively known, it seems likely that its action is mediated by the inhibition of a specific enzyme of helminthes—fumarate reductase. Thiabendazole is active with respect to most nematode infections, including Angyostrongylus cantonesis, Strongyloides stercoralis, Trichinella spiralis, Toxocara canis, Toxocara cati, Ancylostoma caninum, A. braziliense, A. duodenale, Dracunculus medinesis, Capillaria philippinesis, as well as for treating Acaris cantonesis and Shistosoma stercoralis. Synonyms of this drug are mintezol, minzolum, and others.

臨床応用

2-(4-Thiazolyl)benzimidazole (Mintezol) occurs as a whitecrystalline substance that is only slightly soluble in waterbut is soluble in strong mineral acids. Thiabendazole is abasic compound with a pKa of 4.7 that forms complexeswith metal ions.
Thiabendazole inhibits the helminth-specific enzymefumarate reductase. It is not known whether metal ionsare involved or if the inhibition of the enzyme is related tothiabendazole’s anthelmintic effect. Benzimidazole anthelminticdrugs such as thiabendazole and mebendazolealso arrest nematode cell division in metaphase by interferingwith microtubule assembly. They exhibit a highaffinity for tubulin, the precursor protein for microtubulesynthesis.
Thiabendazole has broad-spectrum anthelmintic activity.It is used to treat enterobiasis, strongyloidiasis (threadworminfection), ascariasis, uncinariasis (hookworm infection), andtrichuriasis (whipworm infection). It has also been used torelieve symptoms associated with cutaneous larva migrans(creeping eruption) and the invasive phase of trichinosis. Inaddition to its use in human medicine, thiabendazole iswidely used in veterinary practice to control intestinalhelminths in livestock.

安全性プロファイル

Moderately toxic by ingestion. An experimental teratogen. A questionable carcinogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOX and NOX. See also SULFIDES.

環境運命予測

Thiabendazole does not hydrolyze readily, nor it is metabolized in soil under aerobic or anaerobic conditions. While it photodecomposes in minutes in aqueous solutions, photodecomposition of thiabendazole in soil did not cause more than 40% reduction. Thiabendazole is also only slightly water soluble, and does not migrate in soil. Thus, it is unlikely to contaminate groundwater. If released into the atmosphere, it exists primarily in the particulate phase. In the vapor phase, it will degrade in the atmosphere by reacting with photochemically produced hydroxyl radicals with an estimated half-life of 6 h.

代謝経路

The primary photolytic degradation of thiabendazole involves the cleavage of the thiazole-benzimidazole ring linkage. In animals, thiabendazole is extensively oxidised in bluegill sunfish, hens, goats, sheep, cattle, mice, rats and humans, followed by conjugation. When foliarly applied to plants, degradation to benzimidazole and its conjugates occurred. Benzimidazole formed in plants is mainly due to photolytic action. The primary degradation/metabolic pathways of thiabendazole in water, soil, plants and animals are depicted in Scheme 1.

2-(4-チアゾリル)ベンゾイミダゾール 上流と下流の製品情報

原材料

準備製品


2-(4-チアゾリル)ベンゾイミダゾール 生産企業

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2-(4-チアゾリル)ベンゾイミダゾール  スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS、Raman)


148-79-8(2-(4-チアゾリル)ベンゾイミダゾール)キーワード:


  • 148-79-8
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  • Benzimidazole, 2-(4-thiazolyl)-
  • biogard
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  • Chemviron TK 100
  • chemvirontk100
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  • Equivet TZ
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  • 2-(4-チアゾリル)ベンゾイミダゾール
  • チアベンダゾール
  • チアベンダゾ-ル(農薬用)
  • チアベンダゾール標準品
  • チアベンダゾル
  • 2-(1・3-チアゾール-4-イル)-1H-ベンゾイミダゾール
  • チアベンダゾール(TBZ)
  • 2-(4'-チアゾリル)ベンズイミダゾール
  • 2-(1,3-チアゾール-4-イル)-1H-ベンゾイミダゾール
  • 2‐(1,3‐チアゾール‐4‐イル)‐1H‐ベンゾイミダゾール
  • CS_N-13560-250MG_チアベンダゾールTBZ
  • チアベンダゾール IN METHANOL
  • チアベンダゾール標準物質
  • チアベンダゾール, 0.1 mg/mL in Acetonitrile
  • チアベンダゾール, 100 µg/mL in MeOH
  • チアベンダゾール (JAN)
  • 2-(1,3-チアゾール-4-イル)-1H-1,3-ベンゾジアゾール
  • イノキシウロール
  • オムニゾール
  • サイベンゾール散
  • 4-(1H-ベンゾイミダゾール-2-イル)チアゾール
  • エプロフィル
  • サイアベダゾール
  • ユニテクト
  • ミンゾルム
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  • エキゾール
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  • ボビゾール
  • メルテクト
  • テクト
  • 2-(4-チアゾリル)-1H-ベンゾイミダゾール
  • 駆虫薬成分
  • 生化学
  • 薬理研究用試薬
  • 農薬類,殺虫剤および除草剤など
  • 生活関係標準物質
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  • 有機標準物質
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