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2-(4-チアゾリル)ベンゾイミダゾール

2-(4-チアゾリル)ベンゾイミダゾール 化学構造式
148-79-8
CAS番号.
148-79-8
化学名:
2-(4-チアゾリル)ベンゾイミダゾール
别名:
2-(4-チアゾリル)ベンゾイミダゾール;チアベンダゾール;チアベンダゾ-ル(農薬用);チアベンダゾール標準品;チアベンダゾル;2-(1・3-チアゾール-4-イル)-1H-ベンゾイミダゾール;チアベンダゾール(TBZ);2-(4'-チアゾリル)ベンズイミダゾール;2-(1,3-チアゾール-4-イル)-1H-ベンゾイミダゾール;2‐(1,3‐チアゾール‐4‐イル)‐1H‐ベンゾイミダゾール;CS_N-13560-250MG_チアベンダゾールTBZ;チアベンダゾール IN METHANOL;チアベンダゾール標準物質;チアベンダゾール, 0.1 mg/mL in Acetonitrile;チアベンダゾール, 100 µg/mL in MeOH;チアベンダゾール (JAN)
英語化学名:
Thiabendazole
英語别名:
TBZ;RPH;LSP;g491;Tbdz;tbz6;mk360;TECTO;rival;g 491
CBNumber:
CB1685813
化学式:
C10H7N3S
分子量:
201.25
MOL File:
148-79-8.mol

2-(4-チアゾリル)ベンゾイミダゾール 物理性質

融点 :
298-301°C
比重(密度) :
1.2271 (rough estimate)
蒸気圧:
Negligible at room temperature
屈折率 :
1.5500 (estimate)
貯蔵温度 :
0-6°C
溶解性:
Soluble in methanol and dimethyl sulfoxide.
外見 :
powder
酸解離定数(Pka):
pKa 4.7 (Uncertain)
色:
light yellow
水溶解度 :
0.005 g/100 mL
Merck :
14,9289
BRN :
611403
InChIKey:
WJCNZQLZVWNLKY-UHFFFAOYSA-N
CAS データベース:
148-79-8(CAS DataBase Reference)
NISTの化学物質情報:
Thiabendazole(148-79-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  N,Xi
Rフレーズ  50/53-36/37/38
Sフレーズ  60-61-36-26
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS 番号 DE0700000
TSCA  Yes
国連危険物分類  9
容器等級  III
HSコード  29341000
有毒物質データの 148-79-8(Hazardous Substances Data)
毒性 LD50 in mice, rats, rabbits (g/kg): 3.6, 3.1, >3.8 orally (Robinson)
化審法 (9)-820, (9)-1851
PRTR法 第二種指定化学物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P307+P311 暴露した場合:医師に連絡すること。
P391 漏出物を回収すること。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

2-(4-チアゾリル)ベンゾイミダゾール 価格 もっと(24)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSM-641 チアベンダゾール
Thiabendazole, 0.1 mg/mL in Acetonitrile
148-79-8 1mL ¥7400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-068N チアベンダゾール
Thiabendazole
148-79-8 10mg ¥4400 2018-12-26 購入
東京化成工業 T0830 2-(4-チアゾリル)ベンゾイミダゾール >98.0%(GC)(T)
2-(4-Thiazolyl)benzimidazole >98.0%(GC)(T)
148-79-8 25g ¥3800 2018-12-04 購入
東京化成工業 T0830 2-(4-チアゾリル)ベンゾイミダゾール >98.0%(GC)(T)
2-(4-Thiazolyl)benzimidazole >98.0%(GC)(T)
148-79-8 250g ¥25200 2018-12-04 購入
関東化学株式会社(KANTO) 40650-96 チアベンダゾール標準品 >99.0%(HLC)
Thiabendazole standard >99.0%(HLC)
148-79-8 200mg ¥8000 2018-12-13 購入

2-(4-チアゾリル)ベンゾイミダゾール MSDS


2-(4-Thiazolyl)-benzimidazole

2-(4-チアゾリル)ベンゾイミダゾール 化学特性,用途語,生産方法

外観

白色~わずかにうすい褐色、結晶性粉末~粉末

溶解性

エタノール及びアセトンに溶け、水に溶けにくい。

用途

食品添加物(柑橘類の防カビ剤),駆虫剤(動物用),殺菌剤(失効農薬)

用途

動物用医薬品及び防黴剤定量用の標準品。

用途

食品等中のチアベンダゾール定量用。

効能

駆虫薬, 抗真菌薬

主な用途/役割

イミダゾール・チアゾール系抗菌剤

使用上の注意

アルゴン封入

化学的特性

Light yellow powder

使用

anticoagulant, rodenticide

使用

A drug used in the treatment of helminthiases

使用

Thiabendazole is widely used as a post-harvest systemic fungicide on citrus and bananas. It is active against fruit rots in bananas, citrus, apples and pears; bulb and corm rots in ornamentals; storage rots in sweet potato and potato and is also used to control Dutch elm disease. It is the original benzimidazole anthelmintic for both human and animal health usages.

使用

Systemic fungicide used for diseases of fruits and vegetables and for control of Dutch elm disease.

定義

ChEBI: A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium.

一般的な説明

White or cream-colored odorless, tasteless powder. Sublimes above 590°F. Fluoresces in acidic solution. Formulated as a dust, flowable powder or wettable powder for use as a systemic fungicide and anthelmintic.

空気と水の反応

Insoluble in water.

反応プロフィール

Thiabendazole is incompatible with a number of pesticides, including copper-containing fungicides, and with highly alkaline materials. Thiabendazole is a chelating agent, binding many metals including iron, but not calcium

火災危険

Flash point data for Thiabendazole are not available; however, Thiabendazole is probably combustible.

农业用途

Fungicide: Thiabendazole is a fungicide used to control blight, mold, stain and rot that are found on fruit and vegetables; Dutch elm disease; and diseases found in food storage and other diseases. It is also used to treat roundworms and similar conditions in livestock and humans. Registered for use in EU countries. A U.S. EPA restricted use Pesticide (RUP). U.S. Maximum Allowable Residue Levels for Thiabendazole and its metabolite benzimidazole (free and conjugated) in or on the following food commodities:[40CFR 180.242(a) (1)]: apple, wet pomace 12.0 ppm; Avocado (There are no U.S. registrations on the indicated commodity) 10.0 ppm; banana, post harvest 3.0 ppm; bean, dry, seed 0.1 ppm; beet, sugar, dried pulp 3.5 ppm; beet, sugar, roots 0.25 ppm; beet, sugar, tops 10.0 ppm; cantaloupe (There are no U.S. registrations on the indicated commodity) 15.0 ppm; carrot, roots, postharvest 10.0 ppm; citrus, oil 15.0 ppm; fruit, citrus, group 10, postharvest 10.0 ppm; fruit, pome, group 11, postharvest 5.0 ppm; mango 10.0 ppm; mushroom 40.0 ppm; papaya, postharvest 5.0 ppm; potato, postharvest 10.0 ppm; soybean 0.1 ppm; strawberry (There are no U.S. registrations on the indicated commodity) 5.0 ppm; sweet potato (postharvest to sweet potato intended only for use as seed) 0.05 ppm; wheat, grain 1.0 ppm; wheat, straw 1.0 ppm. [40CFR 180.242(a)(2)]: cattle, meat 0.1 ppm; cattle, meat byproducts 0.4 ppm; goat, meat byproducts 0.4 ppm; Hog, meat byproducts 0.3 ppm; horse, meat byproducts 0.4 ppm; milk 0.1 ppm; sheep, meat byproducts 0.4 ppm. [40CFR 180.2010]: Use/Limits: As a seed treatment for dry pea (including field pea, pigeon pea, chickpea or lentil), using a maximum application rate of 0.075 pounds of active ingredient per 100 pounds of seed. Vines or hay grown from treated seed may not be fed to livestock.

応用例(製薬)

Thiabendazole; a thiazolyl benzimidazole available for oral administration. It is active against most common intestinal nematodes. As a result of its larvicidal and ovicidal activity, it is effective in strongyloidiasis, trichinosis, visceral larva migrans and cutaneous larva migrans.
It is well absorbed from the small intestine. Peak plasma levels are reached about 1–2 h after a single oral dose of the suspension. It is extensively metabolized in the liver to the 5-hydroxy derivative, which is inactive. Most of the drug is excreted within 24 h. About 90% is excreted in the urine, chiefly as glucuronide or sulfate conjugates; the remainder is passed in the feces.
A wide range of unpleasant side effects occur, including nausea and other gastrointestinal upsets, fever and neurological effects. It has been largely replaced by the less toxic benzimidazole carbamates. Although active against Ascaris lumbricoides, E. vermicularis and hookworms, it should not be used as primary therapy for these infections.

製品名

AGROSOL? AGROSOL?T, (with thiram); APL-LUSTER? ARBOTECT? BOVIZOLE? BRODEX? CHEM-TEK? CITRUS LUSTR? DECCO SALT NO.19? E-Z-EX? EPROFIL? EQUIVET TZ? EQUIZOLE? FRESHGARD? FUNGICIDE 4 T? GRANOX? IRGAGUARD? LOMBRISTOP? MERTEC? MERTECT 160? METASOL TK-100? MINTEZOL? MINZOLUM? MK-360? MYCOZOL? NEMAPAN? NSC 525040? OMNIZOLE? POLIVAL? RIVAL? (captan + PCNB + thiabendazole); RPH? RTU-VITAVAX-EXTRA? STA-FRESH? TBZ 6? TECTO? TECTO RPH? TECTO 10P? TECTO 40 F? TESTO? THIABEN? THIABENDAZOLUM? THIABENZAZOLE? THIABENZOLE? THIBENZOL? THIBENZOLE? THIBENZOLE 200? THIBENZOLE ATT? TIABENDAZOLE? TOBAZ? TOP FORM WORMER? VITAVAX?Thiabendazole Chemical class: Benzimidazole

接触アレルゲン

This fungicide and vermifuge agent is widely used in agriculture (for example, forcitrus fruits), and in medical and veterinary practice as an anthelmintic drug.

臨床応用

2-(4-Thiazolyl)benzimidazole (Mintezol) occurs as a whitecrystalline substance that is only slightly soluble in waterbut is soluble in strong mineral acids. Thiabendazole is abasic compound with a pKa of 4.7 that forms complexeswith metal ions.
Thiabendazole inhibits the helminth-specific enzymefumarate reductase. It is not known whether metal ionsare involved or if the inhibition of the enzyme is related tothiabendazole’s anthelmintic effect. Benzimidazole anthelminticdrugs such as thiabendazole and mebendazolealso arrest nematode cell division in metaphase by interferingwith microtubule assembly. They exhibit a highaffinity for tubulin, the precursor protein for microtubulesynthesis.
Thiabendazole has broad-spectrum anthelmintic activity.It is used to treat enterobiasis, strongyloidiasis (threadworminfection), ascariasis, uncinariasis (hookworm infection), andtrichuriasis (whipworm infection). It has also been used torelieve symptoms associated with cutaneous larva migrans(creeping eruption) and the invasive phase of trichinosis. Inaddition to its use in human medicine, thiabendazole iswidely used in veterinary practice to control intestinalhelminths in livestock.

安全性プロファイル

Moderately toxic by ingestion. An experimental teratogen. A questionable carcinogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOX and NOX. See also SULFIDES.

Veterinary Drugs and Treatments

Thiabendazole has been used for the removal of the following parasites in dogs: ascarids (Toxocara canis, T. leonina), Strongyloides stercoralis, and Filaroides. It has been used systemically as an anti-fungal agent in the treatment of nasal aspergillosis and penicillinosis. Topical and otic use of thiabendazole for the treatment of various fungi is also commonly employed.
Thiabendazole is indicated (labeled) for the removal of the following parasites in cattle: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Nematodirus spp., Cooperia spp. and Oesophagostomum radiatum.
Thiabendazole is indicated (labeled) for the removal of the following parasites in sheep and goats: Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Nematodirus spp., Cooperia spp., Chabertia spp., Bunostomum spp. and Oesophagostomum spp.
Thiabendazole is indicated (labeled) for the removal of the following parasites in horses: Strongylus spp., craterstomum spp., Oesphagodontus spp., Posteriostomum spp., Cyathostomum spp., Cylicocylus spp., Cylicostephanus spp., Oxyuris spp., and Parasacaris spp.
Thiabendazole is indicated (labeled) for the removal or prevention of the following parasites in swine: large roundworms (Ascaris suum) (prevention), and in baby pigs infested with Strongyloides ransomi.
Although not approved, thiabendazole has been used in pet birds and llamas. See the Dosage section for more information.
In many geographic areas, significant thiabendazole resistance problems have developed and, for many parasites, other anthelmintics would be a better choice for treatment.
When used topically, thiabendazole has antidermatophytic properties.

代謝経路

The primary photolytic degradation of thiabendazole involves the cleavage of the thiazole-benzimidazole ring linkage. In animals, thiabendazole is extensively oxidised in bluegill sunfish, hens, goats, sheep, cattle, mice, rats and humans, followed by conjugation. When foliarly applied to plants, degradation to benzimidazole and its conjugates occurred. Benzimidazole formed in plants is mainly due to photolytic action. The primary degradation/metabolic pathways of thiabendazole in water, soil, plants and animals are depicted in Scheme 1.

Degradation

Thiabendazole (1) is quite stable in aqueous suspension and in acidic media, and it is stable to heat (PM).
Opening and/or the cleavage of the thiazole-benzimidazole ring linkage appeared to be the primary photolytic degradation pathway. Thiabendazole was photolysed to (benzimidazol-2-yl)carboxamide (2) and benzimidazole (3) under natural sunlight exposure on sugar beet leaf surfaces or on glass plates (Jacob et al., 1975). Thiabendazole was also photolysed in aqueous solution when exposed to a Pyrex glass filtered high pressure mercury lamp (≥290 nm). In addition to 2 and 3, photoproducts included degradates 4-8 (Murthy et al., 1996). Compound 2 was proposed to result from hydrolysis of (benzimidazol-2-yl)nitrile (7). The rate constant for photolysis was not affected sigruficantly by the presence of either fulvic or humic acids, indicating that indirect photolysis does not play a large role in the degradation of thiabendazole.

2-(4-チアゾリル)ベンゾイミダゾール 上流と下流の製品情報

原材料

準備製品


2-(4-チアゾリル)ベンゾイミダゾール 生産企業

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148-79-8(2-(4-チアゾリル)ベンゾイミダゾール)キーワード:


  • 148-79-8
  • 2-(Thiazo-4yl)benzimidazole
  • 2-Thiazole-4-ylbenzimidazole
  • 4-(2-Benzimidazolyl)thiazole
  • 5-(4-Thiazolyl)benzimidazole
  • Apl-Luster
  • Arbotect
  • Benzimidazole, 2-(4-thiazolyl)-
  • biogard
  • Bioguard
  • Bovizole
  • captant
  • Chemviron TK 100
  • chemvirontk100
  • Cropasal
  • Drawipas
  • Eprofil
  • Equivet TZ
  • Mintazd
  • Mintesol
  • Mintezol
  • Minzolum
  • MK 360
  • mk360
  • mk-360
  • Mycozol
  • Nemacin
  • Nemapan
  • Omnizole
  • Ormogal
  • pitrizet
  • 2-(4-チアゾリル)ベンゾイミダゾール
  • チアベンダゾール
  • チアベンダゾ-ル(農薬用)
  • チアベンダゾール標準品
  • チアベンダゾル
  • 2-(1・3-チアゾール-4-イル)-1H-ベンゾイミダゾール
  • チアベンダゾール(TBZ)
  • 2-(4'-チアゾリル)ベンズイミダゾール
  • 2-(1,3-チアゾール-4-イル)-1H-ベンゾイミダゾール
  • 2‐(1,3‐チアゾール‐4‐イル)‐1H‐ベンゾイミダゾール
  • CS_N-13560-250MG_チアベンダゾールTBZ
  • チアベンダゾール IN METHANOL
  • チアベンダゾール標準物質
  • チアベンダゾール, 0.1 mg/mL in Acetonitrile
  • チアベンダゾール, 100 µg/mL in MeOH
  • チアベンダゾール (JAN)
  • 駆虫薬成分
  • 生化学
  • 薬理研究用試薬
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