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β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型)

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 化学構造式
606-68-8
CAS番号.
606-68-8
化学名:
β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型)
别名:
β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型);1-[5-O-[(5'-アデニリルオキシ)(ソジオオキシ)ホスフィニル]-β-D-リボフラノシル]-1,4-ジヒドロ-3-ピリジンカルボアミドナトリウム;Β-ニコチンアミドアデニンジヌクレオチド二ナトリウムN水和物;β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) [生化学用];β-DPNH二ナトリウム水和物 (還元型);β-NADH二ナトリウム水和物 (還元型);β-ジホスホピリジンヌクレオチド二ナトリウム水和物 (還元型);コエンザイムI二ナトリウム水和物 (還元型);コジマーゼ二ナトリウム水和物 (還元型);補酵素I二ナトリウム水和物 (還元型);NADH-2NA;Β‐ニコチンアミドアデニンジヌクレオチド二ナトリウムN水和物;Β-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT;Β-ニコチンアミドアデニンジヌクレオチド二ナトリウム塩水和物, REDUCED FORM;Β-ニコチンアミドアデニンジヌクレオチド還元型, 二ナトリウム塩;Β-ジホスホピリジンヌクレオチド二ナトリウム, 還元型;Β-NADH二ナトリウム塩;Β-ニコチンアミドアデニンジヌクレオチド, 還元型 二ナトリウム塩;Β-ニコチンアミドアデニンジヌクレオチド, 還元型 二ナトリウム塩 水和物;β-ニコチンアミドアデニンジヌクレオチド還元型, 二ナトリウム塩, 98%
英語化学名:
beta-Nicotinamide adenine dinucleotide disodium salt
英語别名:
NADH;DPNH;ENADA;NADH2;N 8129;β-DPNH;Β-NADH;NADH-NA2;NADH 2Na;t hydrate
CBNumber:
CB1709159
化学式:
C21H30N7NaO14P2
分子量:
689.44
MOL File:
606-68-8.mol

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 物理性質

融点 :
140-142°C
貯蔵温度 :
Inert atmosphere,Store in freezer, under -20°C
溶解性:
H2O: 50 mg/mL, clear to nearly clear, yellow
外見 :
Powder
色:
Yellow
PH:
7.5 (100mg/mL in water, ±0.5)
水溶解度 :
soluble
BRN :
5230241
安定性::
Stable. Incompatible with strong oxidizing agents.
InChIKey:
QRGNQKGQENGQSE-WUEGHLCSSA-L
CAS データベース:
606-68-8
EPAの化学物質情報:
Reduced .beta.-nicotinamide adenine dinucleotide disodium salt (606-68-8)

安全性情報

主な危険性  Xn
Rフレーズ  23/24/25-36/37/38-39/23/24/25-40-22
Sフレーズ  26-36/37/39-45-24/25-36/37
WGK Germany  3
3-10-23
TSCA  Yes
HSコード  29349990

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 価格 もっと(58)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01A0930-5045 β-ジホスホピリジンヌクレオチド二ナトリウム, 還元型
beta-Diphosphopyridine Nucleotide, Disodium Salt, Reduced Form
606-68-8 1g ¥8000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01A0930-5045 β-ジホスホピリジンヌクレオチド二ナトリウム, 還元型
beta-Diphosphopyridine Nucleotide, Disodium Salt, Reduced Form
606-68-8 5g ¥28000 2021-03-23 購入
東京化成工業 D0920 β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) [生化学用]
β-Nicotinamide Adenine Dinucleotide Disodium Salt Hydrate, reduced form [for Biochemical Research]
606-68-8 100mg ¥2700 2021-03-23 購入
東京化成工業 D0920 β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) [生化学用]
β-Nicotinamide Adenine Dinucleotide Disodium Salt Hydrate, reduced form [for Biochemical Research]
606-68-8 1g ¥13900 2021-03-23 購入
関東化学株式会社(KANTO) 27110-2A β‐ニコチンアミドアデニンジヌクレオチド二ナトリウムn水和物 98%
β‐Nicotinamide adenine dinucleotide disodium salt n‐hydrate 98%
606-68-8 1g ¥18400 2021-03-23 購入

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) MSDS


beta-Nicotinamide adenine dinucleotide disodium salt

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 化学特性,用途語,生産方法

外観

白色~うすい黄色、粉末

定義

本品は、次の化学式で表されるニコチンアミドアデニンジヌクレオチドの誘導体である。

溶解性

水に易溶, エタノールおよびアセトンに難溶。水に溶けやすく、エタノール及びアセトンに溶けにくい。

用途

補酵素、基質。

化粧品の成分用途

エモリエント剤

使用上の注意

不活性ガス封入

説明

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

化学的特性

beige powder

使用

One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen d onor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configura tion of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.

使用

One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configuration of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.

定義

A dehydrogenase complex that is the reduced formof NAD.

生物活性

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

生物学的応用

Reduced β-nicotinamide adenine dinucleotide (NADH) plays a major role in metabolism as a cofactor in redox reactions and as a mobile electron carrier. NADH is a high energy compound that donates electrons to the electron transport chain to provide energy for ATP production by oxidative phosphorylation. NADH is a required oxidizing cosubstrate in fermentation, which regenerates NAD. NADH is fluorescent, which provides for a relatively simple way to detect NADH in biological samples. NADH is also used in enzyme cycling assays to detect relevant biological molecules in tissues.

純化方法

This coenzyme is available in high purity, and it is advisable to buy a fresh preparation rather than to purify an old sample as purification will invariably lead to a more impure sample contaminated with the oxidised form (NAD). It has UV max at 340nm ( 6,200 M-1cm-1) at which wavelength the oxidised form NAD has no absorption. At 340nm a 0.161mM solution in a 1cm (pathlength) cell has an absorbance of 1.0 unit. The purity is best checked by the ratio A280nm/A340nm ~2.1, a value which increases as oxidation proceeds. The dry powder is stable indefinitely at -20o. Solutions in aqueous buffers at pH ~7 are stable for extended periods at -20o and for at least 8hours at 0o, but are oxidised more rapidly at 4o in a cold room (e.g. almost completely oxidised overnight at 4o). [UV: Drabkin J Biol Chem 175 563 1945, Fluorescence: Boyer & Thorell Acta Chem Scand 10 447 1956, Redox: Rodkey J Biol Chem 234 188 1959, Schlenk in The Enzymes 2 250, 268 1951, Kaplan in The Enzymes 3 105, 112 1960.] Deuterated NADH, i.e. NADD, has been purified through the anion exchange resin AG-1 x 8 (100-200 mesh, formate form) and through a Bio-Gel P-2 column. [Viola et al. Anal Biochem 96 334 1979, Beilstein 26 III/IV 3639.]

β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 上流と下流の製品情報

原材料

準備製品


β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) 生産企業

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606-68-8(β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型))キーワード:


  • 606-68-8
  • eta-d-ribofuranosyl-3-pyridinecarboxamide,disodiumsalt
  • BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, REDUCED FORM DISODIUM SALT
  • BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE, REDUCED, 2NA
  • BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT
  • BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE, DISODIUM SALT
  • beta-Nicotinamide adenine dinucleotidedisodium salthydrate
  • eta-d-ribofuranosyl-3-pyridinecarboxamide, disodium salt beta-nicotinamide adenine dinucleotide, disodium salt, hydrate beta-nicotinamide adenine dinucleotide disodium salt,trihydrate
  • NICOTINAMIDE ADENINE DINUCLEOTIDE (REDUCED) DISODIUM SALT extrapure
  • NICOTINAMIDE ADENINE DINUCLEOTIDE >98% (REDUCED FORM) DISODIUM SALT
  • NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM SALT
  • Nadide sodium
  • b-Nicotinamide adenine dinucleotide reduced form disodium salt
  • β-Nicotinamide adenine dinucleotide, reduced hydrate disodium salt
  • Disodium 1-[(2R,3R,4R,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-3,4-dihydroxy-oxolan-2-yl]pyridine-5-carboxamide
  • Beta-nicotinamide adenine dinucleotide, disodium salt, hydrate, 98%, reduced form
  • 1-[5-O-[(5'-Adenylyloxy)(sodiooxy)phosphinyl]-β-D-ribofuranosyl]-1,4-dihydro-3-pyridinecarboxamide sodium salt
  • β-DPNH, β-NADH, Coenzyme I reduced disodium salt, Diphosphopyridine nucleotide reduced disodium salt
  • beta-Nicotinamide adenine dinucleotide disodium salt, reduced, trihydrate,98%
  • Adenosine 5'-(Trihydrogen diphosphate) P'→5'-ester 1,4-Dihydro- 1-β-D-ribofuranosylnicotinaMide SodiuM Salt
  • Codehydrase I Reduced
  • Codehydrogenase I Reduced
  • CoenzyMe I Reduced
  • CozyMase I Reduced
  • Dihydrocodehydrogenase I
  • DihydrocozyMase DisodiuM
  • DihydronicotinaMide Adenine Dinucleotide DisodiuM
  • ENADA
  • N 8129
  • NADH2
  • Reduced Codehydrogenase I
  • β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型)
  • 1-[5-O-[(5'-アデニリルオキシ)(ソジオオキシ)ホスフィニル]-β-D-リボフラノシル]-1,4-ジヒドロ-3-ピリジンカルボアミドナトリウム
  • Β-ニコチンアミドアデニンジヌクレオチド二ナトリウムN水和物
  • β-ニコチンアミドアデニンジヌクレオチド二ナトリウム水和物 (還元型) [生化学用]
  • β-DPNH二ナトリウム水和物 (還元型)
  • β-NADH二ナトリウム水和物 (還元型)
  • β-ジホスホピリジンヌクレオチド二ナトリウム水和物 (還元型)
  • コエンザイムI二ナトリウム水和物 (還元型)
  • コジマーゼ二ナトリウム水和物 (還元型)
  • 補酵素I二ナトリウム水和物 (還元型)
  • NADH-2NA
  • Β‐ニコチンアミドアデニンジヌクレオチド二ナトリウムN水和物
  • Β-NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED DISODIUM SALT
  • Β-ニコチンアミドアデニンジヌクレオチド二ナトリウム塩水和物, REDUCED FORM
  • Β-ニコチンアミドアデニンジヌクレオチド還元型, 二ナトリウム塩
  • Β-ジホスホピリジンヌクレオチド二ナトリウム, 還元型
  • Β-NADH二ナトリウム塩
  • Β-ニコチンアミドアデニンジヌクレオチド, 還元型 二ナトリウム塩
  • Β-ニコチンアミドアデニンジヌクレオチド, 還元型 二ナトリウム塩 水和物
  • β-ニコチンアミドアデニンジヌクレオチド還元型, 二ナトリウム塩, 98%
  • ヌクレオシド,ヌクレオチド&関連試薬
  • ビタミン
  • ビタミン関連物質
  • 核酸関連酵素&補酵素
  • 生化学
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