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アクロレイン (モノマー)

アクロレイン (モノマー) 化学構造式
107-02-8
CAS番号.
107-02-8
化学名:
アクロレイン (モノマー)
别名:
アクロレイン (モノマー);2-プロペン-1-オン;アクリルアルデヒド;アクアリン;アクラルデヒド;2-プロペナール;アクロレインモノマー;マグナシドB;プロペナール;アリルアルデヒド;マグナシドH;アクロレイン;プロペン-3-オン;アクロレイン,モノマー;アクロレイン STANDARD;アクロレイン、10 MG/ML水溶液;アクロレイン Standard, 100 µg/mL in MeOH: Water 90:10;アクロレイン Standard, 100 µg/mL in Water;アクロレイン Standard, 1000 µg/mL in MeOH: Water 90:10;アクロレイン Standard, 1000 µg/mL in Water
英語化学名:
Acrolein
英語别名:
BXQ;papite;Aqualin;aquinte;Biocide;Crolean;nsc8819;crolein;ACROLEIN;Akrolein
CBNumber:
CB1767603
化学式:
C3H4O
分子量:
56.06
MOL File:
107-02-8.mol

アクロレイン (モノマー) 物理性質

融点 :
−87 °C(lit.)
沸点 :
53 °C(lit.)
比重(密度) :
0.839 g/mL at 25 °C(lit.)
蒸気密度:
1.94 (vs air)
蒸気圧:
4.05 psi ( 20 °C)
屈折率 :
n20/D 1.403(lit.)
闪点 :
−2 °F
貯蔵温度 :
2-8°C
溶解性:
H2O: soluble2 to 3 parts
外見 :
Liquid
臭い (Odor):
Pungent, lacrimatory, intensely irritating odor detectable at 0.02 to 0.4 ppm
臭気閾値(Odor Threshold):
0.0036ppm
爆発限界(explosive limit):
31%
水溶解度 :
Soluble. 21.25 g/100 mL
Sensitive :
Air & Light Sensitive
Merck :
14,128
BRN :
741856
Henry's Law Constant:
(x 10-6 atm?m3/mol at 25 °C): 135 (Snider and Dawson, 1985)
暴露限界値:
NIOSH REL: TWA 0.1 ppm, STEL 0.3 ppm, IDLH 2 ppm; OSHA PEL: TWA 0.1 ppm; ACGIH TLV: TWA 0.1 ppm, STEL 0.3 ppm.
安定性::
Stable, but very readily polymerizes. May have ca. 0.1% hydroquinone added as stabilizer. Flammable. Incompatible with oxidizing agents, reducing agents, oxygen, a variety of other chemicals, light. Very reactive with a wide variety of chemicals. May polymerize violently, especially on contact with strong acids or bases.
InChIKey:
HGINCPLSRVDWNT-UHFFFAOYSA-N
CAS データベース:
107-02-8(CAS DataBase Reference)
NISTの化学物質情報:
2-Propenal(107-02-8)
EPAの化学物質情報:
Acrolein (107-02-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T+,N,T
Rフレーズ  11-24/25-26-34-50-26/28-24
Sフレーズ  23-26-28-36/37/39-45-61-16
RIDADR  UN 1092 6.1/PG 1
WGK Germany  3
RTECS 番号 AS1050000
8-9
自然発火温度 234 °C
TSCA  Yes
国連危険物分類  6.1
容器等級  I
HSコード  29121900
有毒物質データの 107-02-8(Hazardous Substances Data)
毒性 LD50 orally in rats: 0.046 g/kg (Smyth)
消防法 危-4-1-II
化審法 (2)-521
PRTR法 第一種指定化学物質
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P370+P378 火災の場合:消火に...を使用すること。

アクロレイン (モノマー) 価格 もっと(10)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSAPP-9-007 アクロレイン Standard
Acrolein Standard, 100 ug/mL in MeOH: Water 90:10
107-02-8 1mL ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSAPP-9-007-10X アクロレイン Standard
Acrolein Standard, 1000 ug/mL in MeOH: Water 90:10
107-02-8 1mL ¥7400 2018-12-26 購入
東京化成工業 A0137 アクロレイン (モノマー) >95.0%(GC)
Acrolein Monomer (stabilized with HQ) >95.0%(GC)
107-02-8 25mL ¥4900 2018-12-04 購入
東京化成工業 A0137 アクロレイン (モノマー) >95.0%(GC)
Acrolein Monomer (stabilized with HQ) >95.0%(GC)
107-02-8 100mL ¥12000 2018-12-04 購入
Sigma-Aldrich Japan 89116 アクロレイン analytical standard
Acrolein analytical standard
107-02-8 1ml ¥21000 2018-12-25 購入

アクロレイン (モノマー) MSDS


Acrylic aldehyde

アクロレイン (モノマー) 化学特性,用途語,生産方法

用途

アクリル酸、アクリル酸低級アルキルエステル、DL-メチオニン、2-ヒドロキンアジプアルデヒド、1,2,6-ヘキサントリオール、リジン、グルタールアルデヒド、アリルアルコールの中間原料

化学的特性

Acrolein is a highly flammable, clear to yellowish liquid. It has a piercing, disagreeable odor and causes tears.

物理的性質

Colorless to yellow, clear, watery liquid imparting a very sharp, acrid, pungent, or irritating odor. Odor threshold concentrations reported were 0.11 mg/kg by Guadagni et al. (1963), 0.21 ppmv by Leonardos et al. (1969), and 36 ppbv by Nagata and Takeuchi (1990). In addition, Katz and Talbert (1930) reported an experimental detection odor threshold concentration of 4.1 mg/m3 (1.8 ppmv).

使用

Acrolein is used as an antimicrobial agentto prevent the growth of microbes againstplugging and corrosion, to control the aquaticweed and algae, in slime control in papermanufacturing, as a tissue fixative, and inleather tanning.
Because of its widespread use it occursin the environment—in air and water. Afterformaldehyde it is the second most abundantaldehyde, constituting 5% of total aldehydesin air. Acrolein is one of the toxic gasesproduced in a wood or building fire or whenpolyethylene or other polymer substancesburn (Morikawa 1988; Morikawa and Yanai1986). Firefighters are at greater risk ofexposure to this gas.

使用

Acrolein is used in the synthesis of acrylic acid. manufacture of colloidal forms of metals; making plastics, perfumes; warning agent in methyl chloride refrigerant. Has been used in military poison gas mixtures. Used in organic syntheses. Aquatic herbicide.

使用

Acrolein is used in the etherification of food starch up to 0.6% and for the esterification and etherification of food starch up to 0.3% with vinyl acetate up to 7.5%.

使用

Contact herbicide and algicide; injected in water for the control of submerged and floating weeds in irrigation ditches and canals

定義

A colorless liquid unsaturated aldehyde with a pungent odor. It can be polymerized to make acrylate resins.

空気と水の反応

Highly flammable. A dangerous fire risk [Hawley]. Water soluble. Reacts slowly and exothermically with water to give 3-hydroxypropionaldehyde. A hazard can develop from this reaction if acrolein is stored over a layer of water.

反応プロフィール

ACROLEIN, [INHIBITED] can react violently with oxidizing agents. Polymerizes exothermically on contact with small amounts of acids (including sulfur dioxide), alkalis, volatile amines and pyridines, salts, thiourea, oxidizing agents (air) and on exposure to light and heat. Polymerization initiated by amines and pyridines occurs after a deceptive induction period. Water solutions of mineral acids and metal ions can initiate polymerization. The inhibitor (usually hydroquinone) greatly reduces tendency to polymerize. Undergoes Diels-Alder reaction with itself to give acrolein dimer. This can become a runaway reaction at 90°C [Kirk-Othmer, 4th Ed, Vol. 1]. Mixing in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: 2-aminoethanol, ammonium hydroxide, chlorosulfonic acid, ethylenediamine, ethyleneimine [NFPA 1991].

健康ハザード

Acrolein is a highly toxic compound thatcan severely damage the eyes and respiratorysystem and burn the skin. Ingestion can causeacute gastrointestinal pain with pulmonarycongestion.
LD50 value, oral (mice): 40 mg/kg
Acrolein is a strong lachrymator and anasal irritant. Direct contact of liquid in theeyes may result in permanent injury to thecornea. Inhalation can result in severe irritationof the eyes and nose. A concentration of0.5 ppm for 12 minutes can cause intolerableeye irritation in humans. In rats, exposure toa concentration of 16 ppm acrolein in air for4 hours was lethal.
Acrolein can be absorbed through theskin; the spillage of liquid can cause severechemical burns. Skin contact may lead tochronic respiratory disease and producedelayed pulmonary edema. Subcutaneousadministration of acrolein produced degenerationof fatty liver and a general anestheticeffect.
LD50 value, subcutaneous (mice): 30 mg/kg
On the basis of the available data, aconcentration of 68 and 55 ppb may betoxic to aquatic life in fresh and salt water,respectively (U.S. EPA 1980). A concentrationas low as 21 ppb may producechronic toxicity to freshwater aquatic life.Acrolein is reported to be more toxic toaquatic organisms than are phenol, chloroandnitrophenols, aniline, o-xylene, and othertoxic compounds (Holcombe et al. 1987).Rainbow trout, spinally transected, wereexposed to an acutely toxic aqueous concentrationof acrolein to monitor their respiratory–cardiovascular responses. A steadyincrease was recorded in their cough rate.The ventilation rate, oxygen utilization, andheart rate steadily fell throughout their periodof survival.
In a study on inhalation toxicity in rats,Crane et al. (1986) observed that the exposureto 1 atm of acrolein vapors causedphysical incapacitation. The animals lost theability to walk and expired. In a study oncytotoxicity of tobacco-related aldehydes tocultured human bronchial epithelial cells,acrolein was found to be more toxic thanformaldehyde (Graftstrom et al. 1985). Bothcompounds induced DNA damage.
Certain sulfur compounds, such as dithiothreitol and dimercaptopropanol, reacted with acrolein to reduce itstoxicity (Dore et al. 1986). Such protectionagainst its toxicity was observed in isolatedrat hepatocytes.

火災危険

Under fire conditions, polymerization may occur. If inside a container, violent rupture of the container may take place. When heated to decomposition, Acrolein emits highly toxic fumes. Alkalis or strong acids act as catalysts, causing a condensation reaction and liberating energy. Reaction may be very rapid and violent. Readily converted by oxygen to hazardous peroxides and acids. Unstable, avoid exposure to alkalis, strong acids, oxygen, elevated temperatures, such as fire conditions. (Polymerization inside container could cause violent rupture of container under fire conditions.)

燃焼性と爆発性

Acrolein is a highly flammable liquid (NFPA rating = 3) and its vapor can travel a considerable distance and "flash back." Acrolein vapor forms explosive mixtures with air at concentrations of 2.8 to 31% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acrolein fires.

安全性プロファイル

Human poison by inhalation and intradermal routes. Poison experimentally by most routes. Human systemic irritant and pulmonary system effects by inhalation include: lachrymation, delayed hypersensitivity with multiple organ involvement, and respiratory system damage. Severe eye and skin irritant. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen. Dangerous fire hazard when exposed to heat, flame, or oxidizers. An explosion hazard. Incompatible with amines, SO2, metal salts, oxidants, (light + heat). Violent polymerization reaction on contact with strong acid, strong base, weak acid conditions (e.g., nitrous fumes, sulfur dioxide, carbon dioxide), thiourea, or dimethylamine. When heated to decomposition it emits highly toxic fumes; can react vigorously with oxidizing materials. To fight fire, use CO2, dry chemical, or alcohol foam,

職業ばく露

Used as pharmaceutical; slimicide; and in production of cosmetics and food supplements; as an intermediate in the production of glycerine and in the production of methionine analogs (poultry feed protein supplements). It is also used in chemical synthesis (1,3,6-hexametriol and glutaraldehyde); as a liquid fuel; antimicrobial agent, in algae and aquatic weed control; and as a slimicide in paper manufacture; making plastics, drugs, and tear gas. Also, most allyl compounds may be metabolized to allyl alcohol which is metabolized to acrolein.

Carcinogenicity

Acrolein is a reactive intermediate of the commonly used chemotherapeutic drugs cyclophosphamide and ifosphamide. Acrolein-modified DNA was found in human peripheral blood lymphocytes from cancer patients previously treated with cyclophosphamide (a chemotherapeutic), but no association was found for cyclophosphamine. Acrolein has a classification of C, possible human carcinogen, based on limited animal carcinogenicity data and paucity of human evidence for this effect.

Source

Reported in cigarette smoke (150 ppm) and gasoline exhaust (0.2 to 5.3 ppm) (quoted, Verschueren, 1983). May be present as an impurity in 2-methoxy-3,4-dihydro-2H-pyran (Ballantyne et al., 1989a).
Acrolein was detected in diesel fuel at a concentration of 3,400 μg/g (Schauer et al., 1999). Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered automobiles with and without catalytic converters were 0.06 and 3.8 mg/km, respectively (Schauer et al., 2002).
Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of acrolein were 63 mg/kg of pine burned, 44 mg/kg of oak burned, and 56 mg/kg of eucalyptus burned.

環境運命予測

Biological. Microbes in site water degraded acrolein to β-hydroxypropionaldehyde (Kobayashi and Rittman, 1982). This product also forms when acrolein is hydrated in distilled water (Burczyk et al., 1968). When 5 and 10 mg/L of acrolein were statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum, complete degradation was observed after 7 days (Tabak et al., 1981). Activated sludge was capable of degrading acrolein at concentrations of 2,300 ppm but no other information was provided (Wierzbicki and Wojcik, 1965)
Photolytic. Photolysis products include carbon monoxide, ethylene, free radicals and a polymer (Calvert and Pitts, 1966). Anticipated products from the reaction of acrylonitrile with ozone or hydroxyl radicals in the atmosphere are glyoxal, forma
Groundwater. The half-life for acrolein in groundwater was estimated to range from 14 days to 8 weeks (Howard et al., 1991)
Chemical/Physical. Wet oxidation of acrolein at 320°C yielded formic and acetic acids (Randall and Knopp, 1980). May polymerize in the presence of light and explosively in the presence of concentrated acids (Worthing and Hance, 1991) forming disacryl, a white plastic solid (Windholz et al., 1983; Humburg et al., 1989). In distilled water, acroleinwas hydrolyzed to β-hydroxypropionaldehyde (Burczyk et al., 1968; Reinert and Rodgers, 1987; Kollig, 1993). The reported hydrolysis rate constant at pH 7 is 6.68 × 108/year (Kollig, 1993). The estimated hydrolysis half-life in water is 22 days (Burczyk et al., 1968)

代謝経路

When fish are exposed to 14C-acrolein, the metabolites are identified from the edible tissues and there is very little similarity in the metabolism of acrolein among the test species. The most notable observation is that acrolein is never detected in any tissues sampled, and glycidol, glycerol, 1,3- propanediol, and glyceric acid are the major metabolites found in catfish, crayfish, bluegill, and clams, respectively.

貯蔵

Work with acrolein should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and butyl rubber gloves should be worn at all times to prevent eye and skin contact. Acrolein should be used only in areas free of ignition sources. Containers of acrolein should be stored in secondary containers in areas separate from amines, oxidizers, acids, and bases.

輸送方法

Acrolein, stabilized, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquids. Inhalation Hazard Zone A.

純化方法

Purify acrolein by fractional distillation, under nitrogen, drying with anhydrous CaSO4 and then distilling under vacuum. Blacet, Young and Roof [J Am Chem Soc 59 608 1937] distilled it under nitrogen through a 90cm column packed with glass rings. To avoid formation of diacryl, the vapour is passed through an ice-cooled condenser into a receiver cooled in an ice-salt mixture and containing 0.5g catechol. The acrolein is then distilled twice from anhydrous CuSO4 at low pressure, catechol being placed in the distilling flask and the receiver to avoid polymerization. [Alternatively, hydroquinone (1% of the final solution) can be used.] [Beilstein 1 IV 3435.]

不和合性

May form explosive mixture with air. Elevated temperatures or sunlight may cause explosive polymerization. A strong reducing agent; reacts violently with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Polymerizes exothermically on contact with small amounts of acids (including sulfur dioxide), alkalis, volatile amines and pyridines, salts, thiourea, oxidizing agents (air) and on exposure to light, and heat. Polymerization initiated by amines and pyridines occurs after a deceptive induction period. Water solutions of mineral acids and metal ions can initiate polymerization. The inhibitor (usually hydroquinone) greatly reduces tendency to polymerize. Reacts with acids, alkalis, ammonia, amines, oxygenperoxides. Shock-sensitive peroxides or acids may be formed over time. Attacks zinc and cadmium

廃棄物の処理

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration. Conditions are 816 C, 0.5 second minimum for primary combustion; 1093 C, 1.0 second for secondary combustion.

アクロレイン (モノマー) 上流と下流の製品情報

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アクロレイン (モノマー) 生産企業

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107-02-8(アクロレイン (モノマー))キーワード:


  • 107-02-8
  • ACROLEIN
  • ACROLEIN MONOMER
  • ACRYLALDEHYDE
  • ACRYLIC ALDEHYDE
  • ACRALDEHYDE
  • ALLYLALDEHYDE
  • acroleine(dutch,french)
  • Acrylaldehyd
  • ai3-24160
  • Akrolein
  • akrolein(czech)
  • Akroleina
  • akroleina(polish)
  • Aldehyde acrylique
  • aldehydeacrylique
  • aldehydeacrylique(french)
  • Aldeide acrilica
  • aldeideacrilica
  • Aqualin
  • Aqualine
  • aquinte
  • Biocide
  • caswellno009
  • CH2=CHCHO
  • Crolean
  • epapesticidechemicalcode000701
  • Ethylene aldehyde
  • ethylenealdehyde
  • Magnacide H
  • magnacideh
  • アクロレイン (モノマー)
  • 2-プロペン-1-オン
  • アクリルアルデヒド
  • アクアリン
  • アクラルデヒド
  • 2-プロペナール
  • アクロレインモノマー
  • マグナシドB
  • プロペナール
  • アリルアルデヒド
  • マグナシドH
  • アクロレイン
  • プロペン-3-オン
  • アクロレイン,モノマー
  • アクロレイン STANDARD
  • アクロレイン、10 MG/ML水溶液
  • アクロレイン Standard, 100 µg/mL in MeOH: Water 90:10
  • アクロレイン Standard, 100 µg/mL in Water
  • アクロレイン Standard, 1000 µg/mL in MeOH: Water 90:10
  • アクロレイン Standard, 1000 µg/mL in Water
  • アクロレイン Standard, 5.0 mg/mL in para-Dioxane
  • 除草剤
  • 軟体動物駆除剤
  • 土壌殺菌剤
  • 燻蒸剤
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