ゾタロリムス, >90%

ゾタロリムス, >90% 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TRCZ700800	ゾタロリムス, >90% Zotarolimus, >90%	221877-54-9	10mg	￥57000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCZ700800	ゾタロリムス, >90% Zotarolimus, >90%	221877-54-9	5mg	￥29700	2023-06-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCZ700800	ゾタロリムス, >90% Zotarolimus, >90%	221877-54-9	25mg	￥94900	2023-06-01	購入

ゾタロリムス, >90% 化学特性,用途語,生産方法

効能

免疫抑制薬, mTOR阻害薬

説明

Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin . It binds to FKBP prolyl isomerase 1A (FKBP12; IC₅₀ = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC₅₀s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC₅₀s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED₅₀ = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED₅₀ = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 μg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.

化学的特性

Pale Yellow Solid

使用

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.

ゾタロリムス, >90% 上流と下流の製品情報

原材料

準備製品

ゾタロリムス, >90% 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58

221877-54-9(ゾタロリムス, >90%)キーワード:

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• 221877-54-9
• ZOTAROLIMUS
• (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
• A 179578
• ABT 578
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• ZotaroliMus, >90%
• 42-(1-Tetrazolyl)rapamycin
• Resolute
• ZotaroliMus API
• 42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
• (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
• Zotarolimus A 179578
• ZotaroliMus(ABT-578)
• ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
• CS-1162
• Zotarolimus, >
• ZOTAROLIMUS USP/EP/BP
• ZOTAROLIMUS Impurities
• ゾタロリムス, >90%
• ゾタロリムス
• (42S)-42-デオキシ-42-(1H-テトラゾール-1-イル)ラパマイシン
• (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-ジヒドロキシ-19,30-ジメトキシ-12-[(2R)-1-[(1S,3R,4S)-3-メトキシ-4-(1H-1,2,3,4-テトラゾール-1-イル)シクロヘキシル]プロパン-2-イル]-15,17,21,23,29,35-ヘキサメチル-11,36-ジオキサ-4-アザトリシクロ[30.3.1.04,9]ヘキサトリアコンタ-16,24,26,28-テトラエン-2,3,10,14,20-ペンタオン