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ブスルファン

ブスルファン 化学構造式
55-98-1
CAS番号.
55-98-1
化学名:
ブスルファン
别名:
1,4-ブタンジオール ジメタンスルホナート;ビス(メタンスルホン酸)1,4-ブタンジイル;1,4-ジ(メタンスルホニルオキシ)ブタン;ミエロロイコン;1,4-ブタンジオールビスメタンスルホナート;ミトスタン;スルファブチン;ミエルシン;1,4-ブタンジオールジメタンスルホナート;マブリン;ミエロサン;ブスルフェクス;ミトサン;ブスルファン;ビス(メタンスルホン酸)テトラメチレン;ミレラン;ミスルバン;ミエレラン;ブスルファム;ミエロイコン
英語化学名:
Busulfan
英語别名:
gt41;x149;Mylera;mablin;Mitosan;myleran;an33501;mileran;nsc-750;BUSULFAN
CBNumber:
CB2105891
化学式:
C6H14O6S2
分子量:
246.3
MOL File:
55-98-1.mol

ブスルファン 物理性質

融点 :
114-117 °C(lit.)
沸点 :
359.3°C (rough estimate)
比重(密度) :
1.305 (estimate)
屈折率 :
1.5630 (estimate)
闪点 :
9℃
貯蔵温度 :
Hygroscopic, Refrigerator, Under Inert Atmosphere
溶解性:
Very slightly soluble in water, freely soluble in acetone and in acetonitrile, very slightly soluble in ethanol (96 per cent).
外見 :
Crystalline Powder
色:
Pale Brown
水溶解度 :
Decomposes
Merck :
14,1505
BRN :
1791786
安定性::
Moisture Sensitive
CAS データベース:
55-98-1(CAS DataBase Reference)
EPAの化学物質情報:
1,4-Butanediol, dimethanesulfonate(55-98-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+,T,F
Rフレーズ  45-26/27/28-63-46-36/37/38-23/24/25-39/23/24/25-11
Sフレーズ  53-36/37/39-45-28A-36/37-16-7
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS 番号 EK1750000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29053990
有毒物質データの 55-98-1(Hazardous Substances Data)
毒性 LD50 i.v. in rats: 1.8 mg/kg (Scherf)
化審法 (2)-1585
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H310 皮膚に接触すると生命に危険 急性毒性、経皮 1, 2 危険 P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H350 発がんのおそれ 発がん性 1A, 1B 危険
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場所でのみ使用すること。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

ブスルファン 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY14843
Busulfan
55-98-1 25g ¥9000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CAY14843
Busulfan
55-98-1 50g ¥17000 2018-12-26 購入
東京化成工業 B1022 1,4-ブタンジオールジメタンスルホナート >97.0%(T)
1,4-Butanediol Dimethanesulfonate >97.0%(T)
55-98-1 25g ¥8100 2018-12-04 購入
Sigma-Aldrich Japan B1170000 European Pharmacopoeia (EP) Reference Standard
Busulfan European Pharmacopoeia (EP) Reference Standard
55-98-1 b1170000 ¥33600 2018-12-25 購入
Sigma-Aldrich Japan B-058 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
Busulfan solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
55-98-1 1ml ¥60300 2018-12-25 購入

ブスルファン 化学特性,用途語,生産方法

用途

アルキル化剤です。DNAの合成、 複製を阻害し、細胞分裂抑制作用を示します。

用途

白血病の対症療法において使われる抗悪性腫瘍薬

効能

抗悪性腫瘍薬, アルキル化剤, 免疫抑制薬

商品名

ブスルフェクス (大塚製薬); マブリン (大原薬品工業)

化学的特性

White Crystalline Solid

使用

Alkylating agent with antileukemic activity. Antineoplastic

使用

Antineoplastic alkylating agent, the palliative treatment of chronic myeloid leukemia, and insect sterilant.

定義

ChEBI: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.

適応症

Busulfan (Myleran) is a bifunctional methanesulfonic ester that forms intrastrand cross-linkages with DNA. The drug is well absorbed after oral administration and has a plasma half-life of less than 5 minutes. Metabolites and degradation products are excreted primarily in the urine.
Busulfan is used in the palliative treatment of chronic granulocytic leukemia. Daily oral therapy results in decreased peripheral white blood cells and improved symptoms in almost all patients during the chronic phase of the disease. Excessive uric acid production from rapid tumor cell lysis should be prevented by coadministration of allopurinol.
At usual therapeutic dosages, busulfan is selectively toxic to granulocyte precursors rather than lymphocytes. Thrombocytopenia and anemia and less commonly, nausea, alopecia, mucositis, and sterility also may occur. Unusual side effects of busulfan include gynecomastia, a general increase in skin pigmentation, and interstitial pulmonary fibrosis.

brand name

Myleran (GlaxoSmithKline).

一般的な説明

White crystals or powder.

一般的な説明

As an alternative to utilizing aziridines as electrophilic species,it was found that simply utilizing a carbon chain terminated atboth ends by leaving groups gave compounds capable of actingas cross-linking agents.Busulfan utilizestwo sulfonate functionalities as leaving groups separated by afour-carbon chain that reacts with DNA to primarily form intrastrandcross-link at 5'-GA-3' sequences.The sulfonatesare also subject to displacement by the sulfhydryl functionsfound in cysteine and glutathione, and metabolic products areformed as a result of nucleophilic attack by these groups togenerate sulfonium species along with methane sulfonicacid.This is followed by conversion to tetrahydrothiophene,and further oxidation products are subsequently produced togive the sulfoxide and sulfone. The cyclic sulfone known assulfolane may be further oxidized to give 3-hydroxysulfolane.

一般的な説明

Busulfan is available as 2-mg tablets for oral administrationand 10-mL vials for IV administration in the treatment ofchronic myelogenous leukemia (CML) and in high-dosetherapy for refractory leukemia with bone marrow transplant.The agent is well absorbed when given orally, well distributedinto tissues, and crosses the blood-brain barrier.Metabolism occurs in the liver to give mainly methane sulfonic acid by the action of glutathione-S-transferase. Other identified metabolites in humanshave included tetrahydrothiophene-1-oxide, sulfalene,primarily in the urine, and the terminal elimination half-lifeis 2.5 hours. Adverse effects include dose-limiting myelosuppression;nausea and vomiting that occur commonly butare generally mild; and pulmonary symptoms including interstitialpulmonary fibrosis, which is referred to as “busulfanlung,” occurs belatedly (1–10 years posttreatment) andalthough rare, it is severe. Other adverse effects includemucositis, skin rash, impotence, amenorrhea, infertility, hepatoxicity,insomnia, anxiety, and an increased risk of secondarymalignancies. At normal doses, the agent is welltolerated except for the myelosuppression that occurs. Thishas allowed for high-dose therapy with the agent when accompaniedby bone marrow transplant to counter the myelosuppressiveeffects.

空気と水の反応

Busulfan is an alkylating agent which hydrolyzes in water. .

反応プロフィール

Busulfan is an alkylating agent which hydrolyzes in water. . Strong reducers may yield hydrogen sulfide.

危険性

Extremely toxic, carcinogen, clastogenic, teratogenic, immunosuppressive, delayed bone marrow aplasia, cataracts, pigmentation, pulmonary thrombosis, cardiotoxic effects, thrombocytopenia.

火災危険

Flash point data for Busulfan are not available. Busulfan is probably combustible.

安全性プロファイル

Confirmed carcinogen producing leukemia, kidney, and uterine tumors. Experimental neoplastigenic and tumorigenic data. Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and possibly other routes. Ingestion by pregnant women can cause cancer of the reproductive system of the fetus includtng the uterus. Human teratogenic effects by ingestion and possibly other routes include developmental abnormaltties of the eye, ear, craniofacial area including the nose and tongue, gastrointestinal system, endocrine system, urogenital system, and other unspecified areas. Other human reproductive effects by ingestion and possibly other routes include: impotence, changes in the uterus, cervix, and vagina, and menstrual-cycle dtsorders. Experimental reproductive effects. Human systemic effects by ingestion: general arteriolar or venous ddation of the eye, changes in structure or function of salivary glands. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.

Veterinary Drugs and Treatments

Busulfan may be useful in the adjunctive therapy of chronic granulocytic leukemias or polycythemia vera in small animals. Not commonly used in veterinary medicine.

Carcinogenicity

1,4-Butanediol dimethanesulfonate is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

法令条例

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Regulated as a prescription drug subject to labeling and other requirements.

ブスルファン 上流と下流の製品情報

原材料

準備製品


ブスルファン 生産企業

Global( 186)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21676 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58

55-98-1(ブスルファン)キーワード:


  • 55-98-1
  • BUSULFAN
  • 1,4-butanedioldimethanesulphonate
  • 1,4-dimesyloxybutane
  • 1,4-dimethanesulfonoxylbutane
  • 1,4-dimethanesulfonyloxybutane
  • 1,4-dimethanesulphonyloxybutane
  • 1,4-dimethylsulfonoxybutane
  • 1,4-dimethylsulfonyloxybutane
  • 1,4-Butanediol-dimethanesulfonate Esters
  • Mylera
  • 1,4-Butanedioldimethanesulfonate BP2000
  • 1,4-BUTANEDIOLDIMETHYLSULPHONATE
  • 1,4-DIMETHANESULPHONOXYBUTANE
  • 1,4-Butanedioldimethanesulfonate BP2000:Busulphan
  • 1,4-Butanediol dimethanesulfonate, Busulfan
  • Mitosan
  • Myeleran
  • Busulfan,98%
  • Busulfan / 1,4-Butanediol diMethanesulfonate
  • Busulfan/Myleran
  • 4-(Methanesulfonyloxy)butyl Methanesulfonate
  • Busulfan API
  • Busulfan(Myleran,Busulfex,Busulphan)
  • Busulfan (Myleran, Busulfex)
  • 1,4-ButanedioldiMethanesulfonate ,Myleran
  • Busulfan SynonyM 1,4-ButanedioldiMethanesulfonate ,Myleran
  • 1,4-dimethanesulfonate-1,4-butanediol
  • Busulfan solution
  • Busulfan Impurity
  • busuflan
  • 1,4-ブタンジオール ジメタンスルホナート
  • ビス(メタンスルホン酸)1,4-ブタンジイル
  • 1,4-ジ(メタンスルホニルオキシ)ブタン
  • ミエロロイコン
  • 1,4-ブタンジオールビスメタンスルホナート
  • ミトスタン
  • スルファブチン
  • ミエルシン
  • 1,4-ブタンジオールジメタンスルホナート
  • マブリン
  • ミエロサン
  • ブスルフェクス
  • ミトサン
  • ブスルファン
  • ビス(メタンスルホン酸)テトラメチレン
  • ミレラン
  • ミスルバン
  • ミエレラン
  • ブスルファム
  • ミエロイコン
  • 1,4-ブタンジオールジメタンスルホネート
  • 1,4ブタンジオルジメタンスルホネト
  • ジメタンスルホン酸 1,4- ブタンジオール
  • ジメタンスルホン酸 1,4- ブタンジオール 【ブスルファン】
  • ブスルファン (JP17)
  • 生化学
  • 試験研究用抗腫瘍剤
  • 抗腫瘍アルキル化剤
  • 昆虫不妊剤
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