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エチレンジアミン (無水)

エチレンジアミン (無水) 化学構造式
107-15-3
CAS番号.
107-15-3
化学名:
エチレンジアミン (無水)
别名:
エチレンジアミン (無水);エタン-1,2-ジアミン;1,2-エタンジアミン;1,2-ジアミノエタン;2-アミノエチルアミン;エチレンジアミン;エチレンジアミン(無水);エチレンジアミン,無水;エレンジアミン;1MOL/Lエチレンジアミン溶液;500MG/MLエチレンジアミン溶液;エチレンジアミン STANDARD;エチレンジアミン 溶液;エチレンジアミン Standard, 1000 µg/mL in MeOH;エチレンジアミン, 99%;エチレンジアミン (JP17)
英語化学名:
Ethylenediamine
英語别名:
EDA;ai3-24231;NCI-C60402;amerstat274;caswellno437;H2NCH2CH2NH2;Aethaldiamin;algicode106l;Diaminoethane;Ethylendiamin
CBNumber:
CB2127811
化学式:
C2H8N2
分子量:
60.1
MOL File:
107-15-3.mol

エチレンジアミン (無水) 物理性質

融点 :
8.5 °C(lit.)
沸点 :
118 °C(lit.)
比重(密度) :
0.899 g/mL at 25 °C(lit.)
蒸気密度:
2.07 (vs air)
蒸気圧:
10 mm Hg ( 20 °C)
屈折率 :
n20/D 1.4565(lit.)
闪点 :
93 °F
貯蔵温度 :
Flammables area
溶解性:
ethanol: soluble(lit.)
酸解離定数(Pka):
10.712(at 0℃)
外見 :
Liquid, Fuming In Air
比重:
0.899
色:
colorless to pale yellow
PH:
12.2 (100g/l, H2O, 20℃)
臭い (Odor):
Strong ammoniacal odor; ammonia-like mild and ammoniacal odor.
爆発限界(explosive limit):
2-17%(V)
水溶解度 :
miscible
Sensitive :
Air Sensitive
Merck :
14,3795
BRN :
605263
Henry's Law Constant:
1.69(x 10-9 atm?m3/mol) at 25 °C (Westheimer and Ingraham, 1956)
暴露限界値:
TLV-TWA 10 ppm (~25 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 2000 ppm (NIOSH).
InChIKey:
PIICEJLVQHRZGT-UHFFFAOYSA-N
CAS データベース:
107-15-3(CAS DataBase Reference)
NISTの化学物質情報:
Ethylenediamine(107-15-3)
EPAの化学物質情報:
1,2-Ethanediamine(107-15-3)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  C
Rフレーズ  10-21/22-34-42/43
Sフレーズ  23-26-36/37/39-45
RIDADR  UN 1604 8/PG 2
WGK Germany  2
RTECS 番号 KH8575000
10-34
自然発火温度 716 °F
TSCA  Yes
国連危険物分類  8
容器等級  II
HSコード  29212110
有毒物質データの 107-15-3(Hazardous Substances Data)
毒性 LD50 orally in rats: 1.16 g/kg (Smyth)
消防法 危険物第4類第二石油類(水溶性)
化審法 (2)-150
安衛法 57,57-2
PRTR法 第一種指定化学物質
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H334 吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ 感作性、呼吸器 1 危険 P261, P285, P304+P341, P342+P311,P501
H412 長期的影響により水生生物に有害 水生環境有害性、慢性毒性 3 P273, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P342+P311 呼吸に関する症状が出た場合:医師に連絡すること。
P370+P378 火災の場合:消火に...を使用すること。
P405 施錠して保管すること。

エチレンジアミン (無水) 価格 もっと(44)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0105-0093 エチレンジアミン 99.0+% (Titration)
Ethylenediamine 99.0+% (Titration)
107-15-3 25mL ¥1500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01W0105-0093 エチレンジアミン 99.0+% (Titration)
Ethylenediamine 99.0+% (Titration)
107-15-3 500mL ¥2000 2018-12-26 購入
東京化成工業 E0077 エチレンジアミン (無水) >98.0%(GC)(T)
Ethylenediamine Anhydrous >98.0%(GC)(T)
107-15-3 500mL ¥2300 2018-12-04 購入
東京化成工業 E0077 エチレンジアミン (無水) >98.0%(GC)(T)
Ethylenediamine Anhydrous >98.0%(GC)(T)
107-15-3 25mL ¥1600 2018-12-04 購入
関東化学株式会社(KANTO) 14090-01 エチレンジアミン(無水) >98.0%(T)
Ethylenediamine, anhydrous >98.0%(T)
107-15-3 500mL ¥2000 2018-12-13 購入

エチレンジアミン (無水) MSDS


Ethylenediamine

エチレンジアミン (無水) 化学特性,用途語,生産方法

外観

無色澄明の液体

溶解性

水, エタノールに易溶, エーテルに不溶。水及びエタノールに極めて溶けやすい。

用途

キレート剤?エポキシ樹脂硬化剤?殺菌剤?繊維加工剤 (防しわ剤,染料固着剤)?可塑剤?ゴム薬品合成原料;キレート化剤?繊維関係薬品(防しわ剤?界面活性剤?染料固着剤)?イオン交換樹脂?ゴム薬品原料;繊維関係,農薬原料,キレート化剤

効能

キレート剤, 安定化剤

主な用途/役割

ポリウレタン樹脂系接着剤の原料として使用される。

化学的特性

CLEAR liquid

化学的特性

Ethylenediamine, a polyamine, is a strongly alkaline, colorless, clear, thick liquid. Ammonia odor. A solid below 8.5℃. The Odor Threshold is 1.0 ppm

物理的性質

Clear, colorless, volatile, slight viscous, hygroscopic liquid with a sweet, ammonia-like odor. The average least detectable odor threshold concentrations in water at 60 °C and in air at 40 °C were 12 and 52 mg/L, respectively (Alexander et al., 1982).

使用

Ethylenediamine is used as a stabilizerfor rubber latex, as an emulsifier, as aninhibitor in antifreeze solutions, and intextile lubricants. It is also used as a solvent for albumin, shellac, sulfur, and othersubstances.

使用

[Note—Edamine is the recommended contraction for the ethylenediamine radical.].

定義

ChEBI: An alkane-alpha,omega-diamine in which the alkane is ethane.

定義

An organic compound, H2NCH2CH2NH2. It is important in inorganic chemistry because it may function as a bidentantate ligand, coordinating to a metal ion by the lone pairs on the two nitrogen atoms. In the names of complexes it is given the abbreviation en.

調製方法

The production of ethylene-1,2-diamine (EDA) is by the catalytic amination of monoethanolamine or the reaction of aqueous ammonia with 1,2-dichloroethane (Spitz 1979). U.S. Production is estimated at greater than 33,000 tons in 1975.

空気と水の反応

Highly flammable. Hygroscopic. Fumes in the air. Water soluble. Biodegrades readily.

反応プロフィール

A base. Highly reactive with many compounds. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, hydrogen chloride, mesityl oxide, nitric acid, oleum, AgClO4, sulfuric acid, beta-propiolactone and vinyl acetate. Incompatible with strong acids, strong oxidizers (perchlorate salts), and chlorinated organic compounds. Ethylenediamine is also incompatible with halogenated organic compounds and metal halides. May react with nitromethane and diisopropyl peroxydicarbonate. May ignite on contact with cellulose nitrate. Readily absorbs carbon dioxide from the air to give crusty solid deposits. . Ethylenediamine reacts violently with ethylene chlorohydrin. (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1554.).

危険性

Toxic by inhalation and skin absorption, strong irritant to skin and eyes. Flammable, moderate fire risk. Questionable carcinogen.

健康ハザード

Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to Ethylenediamine exposure; therefore, safe threshold limits are difficult to set.

健康ハザード

Human subjects found 100 p.p.m. EDA for a few seconds to be inoffensive but higher concentrations of 200 and 400 p.p.m. produced noticeable irritation of the nasal mucosa (HSDB 1988). Acute EDA ingestion will cause burns of the mouth, esophagus and possibly stomach. Eye contact would be expected to produce a serious burn due to the corrosiveness of the compound. Acute exposure to the skin is likely to produce a skin burn, while chronic exposure will cause a serious burn.
EDA, in addition, is a potent allergen causing hypersensitization in exposed individuals (HSDB 1988). Because of such reactions, it has been difficult to establish threshold limits that will prevent the hypersensitization response. Allergic reactions to EDA in hair and nail care products have been observed among beauty operators, patrons and their husbands (Arena 1979). In the lacquer and shellac industries, exposure to EDA used as a solvent or paint thinner has produced wheezing, heaviness in the chest, severe asthma, allergic coryza and skin rashes (Arena 1979). Workmen exposed to EDA occasionally see halos around objects and have some blurring of vision, presumably due to the effects on the corneal epithelium (Grant 1974). In a study population of 1158 paid volunteers given a patch test, 0.43% showed a positive reaction to EDA (Prystowsky et al 1979).

健康ハザード

Ethylenediamine is a severe skin irritant, pro ducing sensitization, an allergic reaction andblistering on the skin. Pure liquid on contact with the eyes can damage vision. A25% aqueous solution can be injurious to theeyes. Inhalation of its vapors can producea strong irritation to the nose and respiratory tract leading to chemical pneumonitis and pulmonary edema. Such irritation inhumans with symptoms of cough and dis tressed breathing may be noted at concentrations of >400 ppm. Repeated exposure tohigh concentrations of this substance in airmay cause lung, liver, and kidney damage.The toxicity of this compound, however, ismuch less than that of ethylenimine.The acute oral toxicity value in animalswas low to moderate. An oral LD50 value inrats is 500 mg/kg (NIOSH 1986).

火災危険

Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur.

化学反応性

Reactivity with Water Gives off heat, but reaction is not hazardous; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

工業用途

EDA functions as a reactive intermediate in the synthesis of carbamate fungicides and in the preparation of dyes, synthetic waxes, resins, insecticides and asphalt wetting agents (Parmeggiani 1983). EDA is a solvent for casein, albumin, shellac, and sulfur; an emulsifier; a stabilizer for rubber latex; an inhibitor in antifreeze solutions; and a pharmaceutic aid (aminophylline injection stabilizer) (Windholz 1983). It is also an important ingredient in hair-settings, cold wave lotions, and nail polish (Arena 1979).

接触アレルゲン

Ethylenediamine is used in numerous industrial processes as a solvent for casein or albumin, as a stabilizer in rubber latex, and as a textile lubricant. It can be found in epoxy resin hardeners, cooling oils, fungicides, and waxes. Contact dermatitis from ethylenediamine is almost exclusively due to topical medicaments. Occupational contact dermatitis in epoxy resin systems is rather infrequent. Ethylenediamine can crossreact with triethylenetetramine and diethylenetriamine. Ethylenediamine was found to be responsible for sensitization in pharmacists handling aminophylline suppositories, in nurses preparing and administering injectable theophylline, and in a laboratory technician in the manufacture of aminophylline tablets

安全性プロファイル

A human poison by inhalation. Experimental poison by inhalation, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion and skin contact, Experimental reproductive effects. Corrosive. A severe skin and eye irritant. An allergen and sensitizer. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, CS2, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, HCl, mesityl oxide, HNO3, oleum, AgClO4, H2SO4, Ppropiolactone, or vinyl acetate. To fight fwe, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx and NH3. See also MINES.

職業ばく露

Ethylenediamine is used as an intermediate; as a urine acidifier; as a solvent; an emulsifier for casein and shellac solutions; a stabilizer in rubber late. A chemical intermediate in the manufacture of dyes; corrosion inhibitors; synthetic waxes; fungicides, resins, insecticides, asphalt wetting agents; and pharmaceuticals. Ethylenediamine is a degradation product of the agricultural fungicide Maneb.

環境運命予測

Chemical/Physical. Absorbs carbon dioxide forming carbonates (Patnaik, 1992; Windholz et al., 1983).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 893 mg/L. The adsorbability of the carbon used was 21 mg/g carbon (Guisti et al., 1974).

代謝

EDA is absorbed through the skin (Beard and Noe 1981). The penetration rates, distribution and excretion of topically applied [14C]-ethylenediamine have been studied in the rat (Yang et al 1987). Male Wistar rats were percutaneously exposed to solutions of 10, 25 or 50% EDA over about 10% of the body surface. Absorption of EDA was concentration dependent, with about 12, 55 and 61% being absorbed at the 70, 25 and 50% concentration respectively. The terminal plasma half-life of EDA was approximately 4.5 h and the major route of excretion was via the urine. The authors concluded that skin absorption is relatively low and the reduced absorption at higher EDA concentrations may be due to epidermal damage.
When male rats were given 5, 50 or 500 mg/kg doses of [14C]-EDA by oral, endotracheal and i.v. routes, urinary excretion accounted for 42-65% of the administered radioactivity (Yang and Tallant 1982). Fecal excretion amounted to 5-32% of the dose, depending on the route and 6-9% was eliminated in expired air as 14CO2. As the dosage increased from 5 to 50 to 500 mg/kg, there was a pattern of accumulated tissue EDA with a corresponding decrease in metabolite formation. The route of administration did not appear to change the metabolic profile. The major urinary metabolite in the rat was N-acetylethylenediamine (Yang and Tallant 1982). Cotgreave and Caldwell (1983) found that EDA was not detectable in the plasma 2 h after oral and i.v. administration of aminophylline in three healthy human subjects. Davies et al (1983) observed that ethylenediamine uptake in rat brain slices was temperature-dependent and appeared to take place by both sodium dependent and sodium independent mechanisms. Yang et al (1984a) demonstrated age- and, to a lesser extent, sex-related differences in the pharmacokinetics of EDA in Fischer 344 rats.

輸送方法

UN1604 Ethylenediamine, Hazard class: 8; Labels: 8-Corrosive material, 3-Flammable liquid

純化方法

It forms a constant-boiling (b 118.5o, monohydrate, m 10o) mixture with water (23w/w%). [It is hygroscopic and miscible with water.] Recommended purification procedure [Asthana & Mukherjee in J.F.Coetzee (ed), Purification of Solvents, Pergamon Press, Oxford, 1982 cf p 53]: to 1L of ethylenediamine is added 70g of type 5A Linde molecular sieves and shaken for 12hours. The liquid is decanted and shaken for a further 12hours with a mixture of CaO (50g) and KOH (15g). The supernatant is fractionally distilled (at 20:1 reflux ratio) in contact with freshly activated molecular sieves. The fraction distilling at 117.2o /760mm is collected. Finally it is fractionally distilled from sodium metal. All distillations and storage of ethylenediamine should be carried out under nitrogen to prevent reaction with CO2 and water. The material containing 30% water is dried with solid NaOH (600g/L) and heated on a water bath for 10hours. Above 60o, separation into two phases takes place. The hot ethylenediamine layer is decanted off, refluxed with 40g of sodium for 2hours and distilled [Putnam & Kobe Trans Electrochem Soc 74 609 1938]. Ethylenediamine is usually distilled under nitrogen. Alternatively, it is dried over type 5A Linde molecular sieves (70g/L), then a mixture of 50g of CaO and 15g of KOH/L, with further dehydration of the supernatant with molecular sieves followed by distillation from molecular sieves and, finally, from sodium metal. A spectroscopically improved material is obtained by shaking with freshly baked alumina (20g/L) before distillation. [Beilstein 4 IV 1166.]

不和合性

Vapor may form explosive mixture with air. Ethylenediamine is a medium strong base. Violent reaction with strong acids; strong oxidizers; chlorinated organic compounds; acetic acid; acetic anhydride; acrolein, acrylic acid; acrylonitrile, allyl chloride; carbon disulfide; chlorosulfonic acid; epichlorohydrin, ethylene chlorohydrin, oleum, methyl oxide; vinyl acetate. Also incompatible with silver perchlorate, 3-propiolactone, mesityl oxide; ethylene dichloride; organic anhydrides; isocyanates, acrylates, substituted allyls; alkylene oxides; ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks aluminum, copper, lead, tin, zinc, and alloys; some plastics, rubber, and coatings.

廃棄物の処理

Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

エチレンジアミン (無水) 上流と下流の製品情報

原材料

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エチレンジアミン (無水) 生産企業

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107-15-3(エチレンジアミン (無水))キーワード:


  • 107-15-3
  • Ethylenediamine EDA
  • 1,2-Diaminoethane 107-15-3
  • EthylenediaMine, 99+%, AcroSeal
  • ETHYLENEDIAMINE FOR SYNTHESIS
  • EDA EthylenediaMine a
  • EthylenediaMine purified by redistillation, >=99.5%
  • Ethylendiaminum
  • Ethylenediamine BioXtra
  • Ethylenediamine puriss. p.a., absolute, >=99.5% (GC)
  • Ethylenediamine ReagentPlus(R), >=99%
  • Ethylenediamine Vetec(TM) reagent grade, >=98%
  • 1,2-Ethylenediamine
  • ETHYLENEDIAMINE
  • EDA
  • ETHANE-1,2-DIAMINE
  • amerstat274
  • beta-Aminoethylamine
  • caswellno437
  • Diaminoethane
  • Dimethylenediamine
  • epapesticidechemicalcode004205
  • Ethyleendiamine
  • Ethylendiamin
  • Ethylendiamine
  • ethylene-diamine(french)
  • ethylenediamine105
  • H2NCH2CH2NH2
  • NCI-C60402
  • ETHENE DIAMINE
  • ETHYLENEDIAMINE, PH EUR
  • エチレンジアミン (無水)
  • エタン-1,2-ジアミン
  • 1,2-エタンジアミン
  • 1,2-ジアミノエタン
  • 2-アミノエチルアミン
  • エチレンジアミン
  • エチレンジアミン(無水)
  • エチレンジアミン,無水
  • エレンジアミン
  • 1MOL/Lエチレンジアミン溶液
  • 500MG/MLエチレンジアミン溶液
  • エチレンジアミン STANDARD
  • エチレンジアミン 溶液
  • エチレンジアミン Standard, 1000 µg/mL in MeOH
  • エチレンジアミン, 99%
  • エチレンジアミン (JP17)
  • 構造分類
  • 官能性 & α,ω-二官能性アルカン
  • 生化学
  • 糖鎖合成用反応剤
  • α,ω-アルカンジアミン
  • α,ω-二官能性アルカン
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