サリチル酸フィゾスチグミン 化学特性,用途語,生産方法
効能
アセチルコリンエステラーゼ阻害薬 (点眼薬)
化学的特性
solid
使用
Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet
一般的な説明
The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.
反応プロフィール
Behaves as a weak acid in solution.
健康ハザード
PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.
火災危険
When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.
安全性プロファイル
Poison by ingestion,
subcutaneous, intramuscular, intravenous,
and intraperitoneal routes. Human systemic
effects: arrhythmias, nausea or vomiting.
Experimental reproductive effects. When
heated to decomposition it emits toxic
fumes of NOx See also
PHYSOSTIGMINE.
サリチル酸フィゾスチグミン 上流と下流の製品情報
原材料
準備製品