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ペプロマイシン

ペプロマイシン 化学構造式
68247-85-8
CAS番号.
68247-85-8
化学名:
ペプロマイシン
别名:
PEP【ペプレオマイシン】;ブレオマイシンPEP;N1-[3-[[(S)-1-フェニルエチル]アミノ]プロピル]ブレオマイシンアミド;ペプロマイシン;ペプレオマイシン;N1-[3-[[(S)-α-メチルベンジル]アミノ]プロピル]ブレオマイシンアミド
英語化学名:
PEPLOMYCIN
英語别名:
PLM;Fxyd1;Peplocin;PEPLOMYCIN;Pepleocine;NK-631{PEP;Pepreomycin;Pepleomycin;Bleomycin PEP;PEP-Bleomycin
CBNumber:
CB2180678
化学式:
C61H88N18O21S2
分子量:
1473.59
MOL File:
68247-85-8.mol

ペプロマイシン 物理性質

比重(密度) :
1.0908 (rough estimate)
屈折率 :
1.6700 (estimate)
貯蔵温度 :
-20°C
CAS データベース:
68247-85-8

安全性情報

ペプロマイシン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ペプロマイシン 化学特性,用途語,生産方法

効能

抗生物質, 抗悪性腫瘍薬

Originator

Pepleo, Nippon Kayaku, Co., Japan ,1981

使用

Antineoplastic.

Manufacturing Process

In 400 ml of dimethylformamide was dissolved 15.0 g of bleomycinic acid (copper-containing form). To the solution kept at 0°C by cooling were added 1.1 ml of N-methylmorpholine and 10.3 g of 6-chloro-1-pchlorobenzenesulfonyloxybenzotriazole (CCBT) as an activating compound. The mixture was stirred for 5 minutes at 0°C, then admixed with 5.3 g of N[(S)-1'-phenylethyl]-1,3-diaminopropane and further stirred for 1 hour.
After termination of the reaction by adding 200 ml of a 25% aqueous acetic acid solution, the reaction mixture was mixed with 5 liters of cold acetone to precipitate the reaction product. The precipitate was collected by filtration, washed with acetone, and dissolved in 500 ml of distilled water. The resulting aqueous solution was immediately adjusted to pH 6.0 and poured into a column containing 2 liters of CM-Sephadex C-25 (NH4+type) packed in 0.05 M aqueous ammonium chloride solution to adsorb bleomycins.
Using aqueous ammonium chloride solution, elution was performed by passing through the column 20 liters of eluent in which the concentration of ammonium chloride was continually increased from 0.05 to 1.0 M. The unreacted bleomycinic acid was found in the effluent at the ammonium chloride concentration of about 0.05 M and NK631 at the ammonium chloride concentration of about 0.45 M. Both fractions, which showed UV absorption at 292 nm;, were separately collected.
The NK631-containing fraction was poured into a resin column containing 2.6 liters of Amberlite XAD-2. The column was then washed thoroughly with water and eluted with 0.01 N hydrochloric acid in methanol-water (4:1 v/v). A total of 2.5 liters of the blue fraction, which showed UV absorption at 292 mμ, was collected. After evaporating off the methanol from the eluent fraction, the concentrate was adjusted to pH 6.0 with Dowex 44 (OH- type, an anionexchange resin composed of a copolymer of epichlorohydrin and ammonia) and was freeze-dried to obtain 16.1 g (92% yield) of NK631 dihydrochloride (copper-containing form) in the form of blue amorphous powder.
By similar treatment, 280 mg of the unreacted bleomycinic acid (coppercontaining form) were recovered.
In 200 ml of distilled water was dissolved 10.0 g of the NK631 dihydrochloride (copper-containing form). The solution was poured into a column containing 600 ml of Amberlite XAD-2 packed in distilled water. The column was washed successively with 2 liters of an aqueous solution containing 5% of EDTA-Na2, 2.5 liters of a 5% aqueous sodium sulfate solution, and 630 ml of distilled water.
The column was then eluted with 0.0025 N sulfuric acid in methanol-water mixture (1:1 v/v). A total of 900 ml of fractions containing a substance which showed UV absorption at 290 mμ was collected. After removal of methanol by distillation, the residual liquid was adjusted to pH 6.0 with Dowex 44 (OHtype) and freeze-dried to obtain 9.3 g (95% yield) of NK631 monosulfate (copper-free form) in the form of pale yellowish-white amorphous powder.

Therapeutic Function

Antineoplastic

ペプロマイシン 上流と下流の製品情報

原材料

準備製品


ペプロマイシン 生産企業

Global( 10)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
BOC Sciences 16314854226
info@bocsci.com United States 21113 65

68247-85-8(ペプロマイシン)キーワード:


  • 68247-85-8
  • PEPLOMYCIN
  • Bleomycin PEP
  • NK-631{PEP
  • Pelomecin Sulfate:Pepleo Injection
  • PEP-Bleomycin
  • Pepleocine
  • Pepleomycin
  • Peplocin
  • Pepreomycin
  • PLM
  • (S)-N^<1>^-(1-Phenylethyl) bleomycine A2’-b
  • N1-[3-[[(S)-α-Methylbenzyl]amino]propyl]bleomycinamide
  • ANTI-MOUSE PLM (N-TERM) antibody produced in rabbit
  • Phospholemman [Precursor]
  • FXYD domain-containing ion transport regulator 1
  • Fxyd1
  • MONOCLONAL ANTI-PHOSPHO-PLM(S68) antibody produced in mouse
  • Anti-Phospholemman, FXYD1
  • Bleomycinamide, N1-[3-[[(1S)-1-phenylethyl]amino]propyl]-
  • PEPLOMYCIN USP/EP/BP
  • PEP【ペプレオマイシン】
  • ブレオマイシンPEP
  • N1-[3-[[(S)-1-フェニルエチル]アミノ]プロピル]ブレオマイシンアミド
  • ペプロマイシン
  • ペプレオマイシン
  • N1-[3-[[(S)-α-メチルベンジル]アミノ]プロピル]ブレオマイシンアミド
  • 抗腫瘍抗生物質
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