エピナスチン
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- CAS番号.
- 80012-43-7
- 化学名:
- エピナスチン
- 别名:
- 9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン-3-アミン;(±)-3-アミノ-9,13b-ジヒドロ-1H-ジベンズ[c,f]イミダゾ[1,5-a]アゼピン;9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン-3-イルアミン;3-アミノ-9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン;エピナスチン;2,4-ジアザテトラシクロ[12.4.0.02,6.07,12]オクタデカ-1(18),3,7,9,11,14,16-ヘプタエン-3-アミン
- 英語名:
- Epinastine
- 英語别名:
- WAL801;CS-1366;EPINASTINE;ELESTAT;WAL801;Apinastine Base;EPINASTINE BASE;Epinastine (WAL801);Epinastine USP/EP/BP;Epinastine in methanol;9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
- CBNumber:
- CB2230197
- 化学式:
- C16H15N3
- 分子量:
- 249.31
- MOL File:
- 80012-43-7.mol
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エピナスチン 物理性質
- 融点 :
- 205-208°
- 沸点 :
- 428.0±55.0 °C(Predicted)
- 比重(密度) :
- 1.32±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,Room temperature
- 溶解性:
- DMSO : ≥ 50 mg/mL (200.55 mM);Water : < 0.1 mg/mL (insoluble)
- 酸解離定数(Pka):
- 11.2(at 25℃)
- CAS データベース:
- 80012-43-7(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
エピナスチン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
エピナスチン 化学特性,用途語,生産方法
効能
抗アレルギー薬, H1受容体拮抗薬
説明
Epinastine hydrochloride, an orally active antihistaminic agent, was marketed in
Japan for the treatment of bronchial asthma, allergic rhinitis, urticaria, eczema,
dermatitis, and psoriasis vulgaris.Epinastine is one of the most effective
peripherally acting histamine H
1-receptor antagonists without sedative effects.In
addition, it exhibits potent anti-PAF and anti-LT activity which may also contribute
significantly to its antiallergic activity. Chronic epinastine has been reported to
effectively inhibit airway hyper-responsiveness in rats. Potent inhibitory effects of
epinastine on bronchoconstriction induced by histamine and bradykinin, but not by
other chemical mediators, has also been reported. Studies have indicated that there
are no significant differences in pharmacological properties among D-, L-, and
racemic epinastine.
使用
Epinastine is antihistamine and mast cell stabilize that is used in eye drops for the treatment of allergic conjunctivitis.
定義
ChEBI: A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
臨床応用
Epinastine is a potent, long-acting H1 antihistamine and an inhibitor of the release of
histamine and other transmitters from mast cells. It has some affinity for H2 receptors as well.
It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is
classified as a nonsedating antihistamine.
エピナスチン 上流と下流の製品情報
原材料
準備製品
エピナスチン 生産企業
Global( 153)Suppliers
80012-43-7(エピナスチン)キーワード:
- 80012-43-7
- 3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine
- EPINASTINE
- EPINASTINE BASE
- 9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
- Apinastine Base
- 3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine
- CS-1366
- ELESTAT;WAL801
- WAL801
- 1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-
- Epinastine USP/EP/BP
- Epinastine (WAL801)
- EpinastineQ: What is
Epinastine Q: What is the CAS Number of
Epinastine Q: What is the storage condition of
Epinastine
- 9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
- Epinastine in methanol
- 9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン-3-アミン
- (±)-3-アミノ-9,13b-ジヒドロ-1H-ジベンズ[c,f]イミダゾ[1,5-a]アゼピン
- 9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン-3-イルアミン
- 3-アミノ-9,13b-ジヒドロ-1H-ジベンゾ[c,f]イミダゾ[1,5-a]アゼピン
- エピナスチン
- 2,4-ジアザテトラシクロ[12.4.0.02,6.07,12]オクタデカ-1(18),3,7,9,11,14,16-ヘプタエン-3-アミン
- ヒスタミンＨ１受容体遮断薬
- 耳鼻薬
- 抗喘息薬
- 皮膚用薬