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RS23597-190塩酸塩

RS23597-190塩酸塩 化学構造式
149719-06-2
CAS番号.
149719-06-2
化学名:
RS23597-190塩酸塩
别名:
RS23597-190塩酸塩;4-アミノ-5-クロロ-2-メトキシ安息香酸3-(ピペリジン-1-イル)プロピル・塩酸塩;RS-23597-190
英語名:
RS 23597-190 HYDROCHLORIDE
英語别名:
RS23597-190HCl;RS 23597-190 hydroch;RS 23597-190 >=98% (HPLC);RS 23597-190 HYDROCHLORIDE;RS 23597 190 hydrochloride,RS 23597190 hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
CBNumber:
CB2242093
化学式:
C16H24Cl2N2O3
分子量:
363.28
MOL File:
149719-06-2.mol

RS23597-190塩酸塩 物理性質

貯蔵温度 :
Sealed in dry,2-8°C
溶解性:
Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)
外見 :
Powder
水溶解度 :
Soluble to 100 mM in water

安全性情報

RS23597-190塩酸塩 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC0728 RS23597-190塩酸塩
RS 23597-190 Hydrochloride 		149719-06-2 10mg ￥34000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01MAS100003
3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride 		149719-06-2 1g ￥1564900 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC0728 RS23597-190塩酸塩
RS 23597-190 Hydrochloride 		149719-06-2 50mg ￥144000 2024-03-01 購入

RS23597-190塩酸塩 化学特性,用途語,生産方法

使用

RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.

生物活性

A high affinity, selective competitive antagonist at 5-HT 4 receptors.

Biochem/physiol Actions

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).

RS23597-190塩酸塩 上流と下流の製品情報

原材料

準備製品

RS23597-190塩酸塩 生産企業

Global( 34)Suppliers
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149719-06-2(RS23597-190塩酸塩)キーワード:

5-クロロ-2-メトキシ安息香酸メチル 2-メトキシ-4-アミノ安息香酸メチル 5-クロロ-2-メトキシ安息香酸 2-ヒドロキシ-5-クロロ安息香酸メチル 5-アミノ-4-クロロ-2-メチルフェノール 4-アミノ-5-クロロ-2-メトキシ安息香酸メチル 4-アミノ-5-クロロ-2-エトキシ安息香酸 4-アミノ-2-ヒドロキシ安息香酸メチル 2-クロロ-3-メトキシアニリン 4-アミノ-3-クロロ安息香酸メチル 5-クロロサリチル酸 4-アミノ-2-メトキシ安息香酸 RS23597-190塩酸塩 4-アミノ-3-クロロ安息香酸
  • 149719-06-2
  • 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE
  • RS 23597-190 HYDROCHLORIDE
  • RS23597-190HCl
  • 3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
  • 3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride
  • 4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
  • 3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL
  • 4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride
  • RS 23597-190 >=98% (HPLC)
  • RS 23597-190 hydroch
  • Benzoic acid, 4-amino-5-chloro-2-methoxy-, 3-(1-piperidinyl)propyl ester, hydrochloride (1:1)
  • 4-amino-5-chloro-2-methoxy-Benzoic acid 3-(1-piperidinyl)propyl ester hydrochloride (1:1)
  • RS 23597 190 hydrochloride,RS 23597190 hydrochloride
  • RS23597-190塩酸塩
  • 4-アミノ-5-クロロ-2-メトキシ安息香酸3-(ピペリジン-1-イル)プロピル・塩酸塩
  • RS-23597-190
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