セシンH3

セシンH3 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2849	SecinH3	853625-60-2	5mg	￥34000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2849	SecinH3	853625-60-2	10mg	￥60000	2021-03-23	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2849	SecinH3	853625-60-2	50mg	￥262000	2021-03-23	購入

セシンH3 化学特性,用途語,生産方法

使用

SecinH3 is a Sec7 cytohesin inhibitor.

一般的な説明

A cell-permeable triazolo compound that acts as a Sec7 domain-binding (K_d ≤250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC₅₀ ≤5.6 μM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC₅₀ ≥65 μM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.

生物活性

Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC 50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μ M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

セシンH3 上流と下流の製品情報

原材料

準備製品

セシンH3 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4647	58
TargetMol Chemicals Inc.	021-33632979 15002134094	marketing@targetmol.com	China	7934	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55

853625-60-2(セシンH3)キーワード:

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• 853625-60-2
• N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
• SECINH3
• N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide
• 3]dioxol-5-yl)-3-methoxy-1H-1
• 4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide
• N-(4-(5-(benzo[d][1
• CS-2379
• Acetamide, N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-
• N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1,2,4-triazol-1-yl]phenyl]-2-phenylsulfanylacetamide
• セシンH3
• N-{4-[5-(2H-1,3-ベンゾジオキソール-5-イル)-3-メトキシ-1H-1,2,4-トリアゾール-1-イル]フェニル}-2-(フェニルスルファニル)アセトアミド
• N-[4-[3-(1,3-ベンゾジオキソール-5-イル)-5-メトキシ-2H-1,2,4-トリアゾール-2-イル]フェニル]2-(フェニルチオ)アセトアミド