アンチマイシンA3

アンチマイシンA3 化学構造式
522-70-3
CAS番号.
522-70-3
化学名:
アンチマイシンA3
别名:
3-メチルブタン酸(3S,4R,7R,8R,9S)-3-[(3-ホルミルアミノ-2-ヒドロキシベンゾイル)アミノ]-4,9-ジメチル-2,6-ジオキソ-7-ブチル-1,5-ジオキソナン-8-イル/2-メチルブタン酸(3S,4R,7R,8R,9S)-3-[(3-ホルミルアミノ-2-ヒドロキシベンゾイル)アミノ]-4,9-ジメチル-2,6-ジオキソ-7-ブチル-1,5-ジオキソナン-8-イル;ブラストマイシン;アンチマイシンA3
英語名:
Antimycin A3
英語别名:
Nsc58239;Blastmycin;Aids012099;A 80021F34;Aids-012099;antimycina3;BlastMycin, NSC 58239;Antimycin A3 DISCONTINUED, offer A697508;ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer;isovalericacid,n-esterwithn-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-d
CBNumber:
CB2259813
化学式:
C26H36N2O9
分子量:
520.57
MOL File:
522-70-3.mol

アンチマイシンA3 物理性質

融点 :
170.5-171.5° (Liu); 174-174.5° (Kinoshita)
比旋光度 :
D26 +64.3° (chloroform) (Liu); D24 +80° (Kinoshita)
沸点 :
603.87°C (rough estimate)
比重(密度) :
1.2829 (rough estimate)
屈折率 :
1.5300 (estimate)
貯蔵温度 :
−20°C
溶解性:
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
外見 :
A solid
CAS データベース:
522-70-3

安全性情報

主な危険性  T
Rフレーズ  23/24/25
Sフレーズ  36/37/39-45
RIDADR  3172
RTECS 番号 NY1502900
国連危険物分類  6.1(a)
容器等級  II
毒性 LD50 in mice (mg/kg): 1.8 i.p.; 1.6 s.c. (Watanabe)

アンチマイシンA3 化学特性,用途語,生産方法

化学的特性

Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.

使用

Antimycin A3 is a homologue of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A4. Antimycin A3 is a more polar analogue of A1 and A2. Like all antimycins, antimycin A3 is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. Lack of availability of the individual antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the antimycin complex.

職業ばく露

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

アンチマイシンA3 上流と下流の製品情報

原材料

準備製品


  • 522-70-3
  • antimycina3
  • ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer
  • isovalericacid,n-esterwithn-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-d
  • [2R-(2R*,3S*,6S*,7R*,8R*)]-8-butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
  • Blastmycin
  • 3-Methyl-butyric acid (2R,3S,6S,7R,8R)-8-butyl-3-{[1-(3-formylamino-2- hydroxy-phenyl)-methanoyl]-amino}-2,6-dimethyl-4,9-dioxo-[1,5]dioxonan -7-yl ester
  • A 80021F34
  • Aids012099
  • Aids-012099
  • Nsc58239
  • BlastMycin, NSC 58239
  • Antimycin A3 DISCONTINUED, offer A697508
  • 3-メチルブタン酸(3S,4R,7R,8R,9S)-3-[(3-ホルミルアミノ-2-ヒドロキシベンゾイル)アミノ]-4,9-ジメチル-2,6-ジオキソ-7-ブチル-1,5-ジオキソナン-8-イル/2-メチルブタン酸(3S,4R,7R,8R,9S)-3-[(3-ホルミルアミノ-2-ヒドロキシベンゾイル)アミノ]-4,9-ジメチル-2,6-ジオキソ-7-ブチル-1,5-ジオキソナン-8-イル
  • ブラストマイシン
  • アンチマイシンA3
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