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Histone Acetyltransferase Inhibitor IV, CPTH2

化学構造式
357649-93-5
CAS番号.
357649-93-5
化学名:
别名:
英語名:
Histone Acetyltransferase Inhibitor IV, CPTH2
英語别名:
CPTH2;Histone Acetyltransferase Inhibitor IV, CPTH2;Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone;Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
CBNumber:
CB22602855
化学式:
C14H14ClN3S
分子量:
291.8
MOL File:
357649-93-5.mol
MSDS File:
SDS

Histone Acetyltransferase Inhibitor IV, CPTH2 物理性質

融点 :
190-191 °C
沸点 :
460.3±37.0 °C(Predicted)
比重(密度) :
1.38±0.1 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSOに可溶
外見 :
粉
酸解離定数(Pka):
14.57±0.20(Predicted)
色:
白からベージュ
水溶解度 :
Water: < 0.1 mg/mL (insoluble)
Sensitive :
Light Sensitive
安定性：:
-20°C の DMSO 溶液で最大 1 か月間保存できます。

安全性情報

WGK Germany  nwg

Histone Acetyltransferase Inhibitor IV, CPTH2 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCC781460
CPTH2 		357649-93-5 250mg ￥388500 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCC781460
CPTH2 		357649-93-5 25mg ￥55300 2023-06-01 購入
Sigma-Aldrich Japan C9873 ≥98% (HPLC), powder
CPTH2 ≥98% (HPLC), powder		 357649-93-5 5mg ￥35400 2024-03-01 購入
Sigma-Aldrich Japan C9873 ≥98% (HPLC), powder
CPTH2 ≥98% (HPLC), powder		 357649-93-5 25mg ￥106000 2024-03-01 購入

Histone Acetyltransferase Inhibitor IV, CPTH2 化学特性,用途語,生産方法

使用

CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo.

一般的な説明

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Histone Acetyltransferase Inhibitor IV, CPTH2 上流と下流の製品情報

原材料

シクロペンタノンチオセミカルバゾン 4-クロロフェナシルブロミド シクロペンタノン

準備製品

Histone Acetyltransferase Inhibitor IV, CPTH2 生産企業

Global( 72)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Hefei Mokai Pharmaceutical Technology Co., Ltd 18130062233
 3362556465@qq.com China 8000 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Shanghai Aladdin Bio-Chem Technology Co.,LTD 18521735133 18521732826;
 market@aladdin-e.com China 25015 65
TargetMol Chemicals Inc. 021-33632979 15002134094
 marketing@targetmol.com China 7934 58
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
info@tsbiochem.com China 8073 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189
 mychess007@163.com China 1994 55

  スペクトルデータ(1HNMR)

Histone Acetyltransferase Inhibitor IV, CPTH2(357649-93-5)1HNMR

357649-93-5()キーワード:

N-(ジメチルアミノ)スクシンアミド酸 アパベタロン 4-フェニル酪酸ナトリウム 5-カルボキシ-8-ヒドロキシキノリン
  • 357649-93-5
  • Histone Acetyltransferase Inhibitor IV, CPTH2
  • CPTH2
  • Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
  • Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone
  • 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
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