1-(2-ブロモフェニル)-3-[(3S)-1-[5-(トリフルオロメチル)-2-ピリジル]-3-ピロリジニル]尿素 化学特性,用途語,生産方法
説明
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin . SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pK
is = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). It has been shown to induce rapid, reversible inhibition of capsaicin (IC
50 = 3 nM)-, acid (pH 5.3)-, or heat (50°C; IC
50 = 6 nM)-mediated activation of human TRPV1 (at -70 mV).
1-(2-ブロモフェニル)-3-[(3S)-1-[5-(トリフルオロメチル)-2-ピリジル]-3-ピロリジニル]尿素 上流と下流の製品情報
原材料
準備製品