トレラグリプチンコハク酸塩
トレラグリプチンコハク酸塩 物理性質
- 貯蔵温度 :
- -20°C
- 溶解性:
- Soluble in DMSO
- 外見 :
- Powder
- 色:
- オフホワイトの無地
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
トレラグリプチンコハク酸塩 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
トレラグリプチンコハク酸塩 化学特性,用途語,生産方法
効能
糖尿病治療薬, DPP-4阻害薬
商品名
ザファテック (武田薬品工業)
説明
Similar to omarigliptin,
trelagliptin succinate (XIX) is a highly selective, orally
delivered inhibitor of DPP-4 developed by Takeda Pharmaceuticals
and approved in Japan in March 2015 for the
treatment of type 2 DM. Interestingly, trelagliptin is
structurally similar to alogliptin, a DPP-4 inhibitor also
marketed by Takeda and described in our 2010 review,
differing only in the presence of a fluorine in the 5-position of
the cyanobenzyl moiety. Both trelagliptin and alogliptin are
potent inhibitors of DPP-4, with IC50s of 1.3 and 5.3 nM,
respectively. Notably, while similar drugs are dosed once
daily, trelagliptin is the first DPP-4 inhibitor approved for onceweekly
dosing. Kinetic analysis has revealed that trelagliptin is a
substrate-competitive, reversible, slow-binding inhibitor (t1/2 for
dissociation = ca. 30 min) of DPP-4, although the dissociation
time is insufficient to explain its long-acting effects. In a phase
III trial, once-weekly trelagliptin (100 mg) showed similar
efficacy and safety to once-daily alogliptin (25 mg) in patients
with type 2 DM inadequately controlled by diet and exercise.
The medicinal chemistry discovery of trelagliptin and
alogliptin as well as reviews of this class of compounds
have been published.
使用
Trelagliptin succinate (SYR-472) is a selective, long acting dipeptidyl peptidase-4 (DPP-4) inhibitor. An antidiabetic agent.
Orally active DPP-4 inhibitor that produces clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes. SYR472 has a long duration of action and is well tolerated in clinical studies.
臨床応用
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor used for the treatment of type 2 diabetes mellitus. Trelagliptin (as the salt Trelagliptin succinate) was approved for use in Japan in March 2015. Takeda, the company that developed Trelagliptin, chose to not get approval for the drug in the USA and EU.
トレラグリプチンコハク酸塩 上流と下流の製品情報
原材料
準備製品
トレラグリプチンコハク酸塩 生産企業
Global( 425)Suppliers
| 名前 |
電話番号 |
電子メール |
国籍 |
製品カタログ |
優位度 |
|
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
|
+86-029-86185165 +8618629664246
|
guoyuan@eastchinapharm.com |
China |
1615 |
58 |
|
Firsky International Trade (Wuhan) Co., Ltd
|
+8615387054039
|
admin@firsky-cn.com |
China |
436 |
58 |
|
Hangzhou ICH Biofarm Co., Ltd
|
+undefined8613073685410
|
sales@ichemie.com |
China |
985 |
58 |
|
Zibo Hangyu Biotechnology Development Co., Ltd
|
+86-0533-2185556 +8617865335152
|
Mandy@hangyubiotech.com |
China |
11013 |
58 |
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
+86-13474506593 +86-13474506593
|
sarah@tnjone.com |
China |
864 |
58 |
|
Capot Chemical Co.,Ltd.
|
571-85586718 +8613336195806
|
sales@capotchem.com |
China |
29797 |
60 |
|
Beijing Cooperate Pharmaceutical Co.,Ltd
|
010-60279497
|
sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
|
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
|
info@tianfuchem.com |
China |
21695 |
55 |
|
Hangzhou FandaChem Co.,Ltd.
|
008657128800458; +8615858145714
|
fandachem@gmail.com |
China |
9348 |
55 |
|
Nanjing ChemLin Chemical Industry Co., Ltd.
|
025-83697070
|
product@chemlin.com.cn |
CHINA |
3012 |
60 |
トレラグリプチンコハク酸塩 スペクトルデータ(1HNMR)
1029877-94-8(トレラグリプチンコハク酸塩)キーワード:
- 1029877-94-8
- Trelagliptin Succinate (SYR-472)
- SYR 111472 succinate
- SYR-472 succinate
- SYR-472 Trelagliptin succinat
- Trelagliptin succinate(SRY-472)
- Trelagliptin succinate
SYR 111472 succinate
- SRY-472
- Telagliptin Succinate
- Trelagliptin succinate, >=98%
- Butanedioic acid, compd. with 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile (1:1)
- (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-f
- Trelagliptin Succinate API
- Trelagliptin (succinate)
- SYR 472 succinate
- SYR472 succinate
- Triglitastat succinate
- (R)-2-[[6-(3-Amino-1-piperidyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl]methyl]-4-fluorobenzonitrile Succinate
- Trelagliptin succinate high quality Cas number：1029877-94-8
- CS-924
- SYR-472 SUCCINATE; SYR472 SUCCINATE; SYR 472 SUCCINATE
- Trelagliptin succinate - SYR 111472 succinate | SYR 472
- TrelChemicalbookagliptinsuccinate
- Trelagliptin Impurity 81
- SYR-472 succinate. Trelagliptin
- Trelagliptin succinate ISO 9001：2015 REACH
- Troglitinesuccinate
- relagliptin succinate
- Troxagliptin succinate
- Trelagliptin succinat
- Trogliptin succinate
- トレラグリプチンコハク酸塩
- トレラグリプチンコハク酸塩 (JAN)