6-ヒドロキシドーパミン·臭化水素酸塩
6-ヒドロキシドーパミン·臭化水素酸塩 物理性質
- 融点 :
- 216-220 °C(lit.)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO（微量）、メタノール（微量）、水（微量）
- 外見 :
- 個体
- 色:
- 黄褐色から茶色
- BRN :
- 3713280
- 安定性：:
- 吸湿性、光感受性
- InChIKey:
- MLACDGUOKDOLGC-UHFFFAOYSA-N
- CAS データベース:
- 636-00-0(CAS DataBase Reference)
6-ヒドロキシドーパミン·臭化水素酸塩 価格
もっと(14)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLCM01851 |
6-Hydroxydopamine.Hydrobromide |
636-00-0 |
250mg |
￥78800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-3370 |
6-ヒドロキシドーパミン臭化水素酸塩
6-Hydroxydopamine hydrobromide |
636-00-0 |
250mg |
￥83300 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-3370 |
6-ヒドロキシドーパミン臭化水素酸塩
6-Hydroxydopamine hydrobromide |
636-00-0 |
1g |
￥274500 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
162957 |
6-ヒドロキシドーパミン 臭化水素酸塩 95%
6-Hydroxydopamine hydrobromide 95% |
636-00-0 |
50mg |
￥11500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
162957 |
6-ヒドロキシドーパミン 臭化水素酸塩 95%
6-Hydroxydopamine hydrobromide 95% |
636-00-0 |
250mg |
￥38200 |
2024-03-01 |
購入 |
6-ヒドロキシドーパミン·臭化水素酸塩 化学特性,用途語,生産方法
説明
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.
化学的特性
beige to brown crystalline powder
使用
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
一般的な説明
Solutions should be freshly prepared and protected from exposure to light.
6-ヒドロキシドーパミン·臭化水素酸塩 上流と下流の製品情報
原材料
準備製品
6-ヒドロキシドーパミン·臭化水素酸塩 生産企業
Global( 131)Suppliers
6-ヒドロキシドーパミン·臭化水素酸塩 スペクトルデータ(IR1、IR2、MS)
636-00-0(6-ヒドロキシドーパミン·臭化水素酸塩)キーワード:
- 636-00-0
- 1,2,4-Benzenetriol,5-(2-aminoethyl)-, hydrobromide (1:1)
- 2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide
- 2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE
- 2,5-DIHYDROXYTYRAMINE HYDROBROMIDE
- 2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE
- 6-HYDROXYDOPAMINE HBR
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- 2,4,5-Trihydroxyphenethylamine
- 5-(2-aminoethyl)-4-hydroxypyrocatechol hydrobromide
- 6-Hydroxydopamine hydrbromide
- 6-HYDROXYDOPAMINE HYDROBROMIDE WITH ASCO RBIC ACID
- 6-HYDROXYDOPAMINE HYDROBROMIDE 99%
- 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
- 6-Hydroxydopamine·hydrogen bromide
- 6-Hydroxydopamine hydrobromide,95%
- 6-Hydroxydopamine hydrobromide,99%
- 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide
- 6-HYDROXYDOPAMINE HYDROBROMIDE, CRYSTALL IZED
- 6-Hydroxydopamine hydrobromide,2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
- KEMPTIDE, SYNTHETIC, >97% PURITY
- 6-Hydroxydopaminehydrobromide/ascorbicacid
- 5-(2-aMinoethyl)benzene-1,2,4-triol hydrobroMide
- Oxidopamine HBr
- 6-Hydroxydopamine hydrobromide contains ascorbic acid as stabilizer, >=98% (HPLC)
- 6-OHDA (hydrobromide)
- 6-HYDROXYDOPAMINE HYDROBROMIDE USP/EP/BP
- 6-OHDA HBr (Oxidopamine hydrobromide)
- neurotoxicity,Autophagy,Interleukin Related,Parkinson’s disease,6-Hydroxydopamine,Oxidopamine hydrobromide,Caspase,6-OHDA,Lesch-Nyhan syndrome,PC12 cells,p38 MAPK,Mitophagy,inhibit,Inhibitor,Mitochondrial Autophagy,p-p38,COX,Prostaglandin E synthase,attention-deficit hyperactivity disorder,PGE2,Dopamine Receptor,SH-SY5Y cells,Apoptosis,Oxidopamine,Neuro-2a cells,Cyclooxygenase,PGE synthase
- Oxidopamine (6-OHDA) hydrobromide
- 5-(2-アミノエチル)ベンゼン-1,2,4-トリオール·臭化水素酸塩
- 6-ヒドロキシドーパミン臭化水素酸塩
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- 6-ヒドロキシドーパミン·臭化水素酸塩
- 6-ヒドロキシドーパミン 臭化水素酸塩
- 5-(2-アミノエチル)ベンゼン-1,2,4-トリオール・臭化水素酸塩
- 6-ヒドロキシドーパミン・臭化水素酸塩
- 6-ヒドロキシドーパミン・臭化水素