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MRT67307

化学構造式
1190379-70-4
CAS番号.
1190379-70-4
化学名:
别名:
英語名:
MRT67307
英語别名:
MRT68921(HCI);MRT68921(HCl);MRT68921 (free base);MRT68921;MRT-68921;MRT 68921;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop;N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide;N-(3-((5-cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide;Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-;N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide , MRT68921
CBNumber:
CB23043299
化学式:
C25H34N6O
分子量:
434.58
MOL File:
1190379-70-4.mol

MRT67307 物理性質

貯蔵温度 :
Store at -20°C
溶解性:
insoluble in H2O; insoluble in EtOH; ≥2.18 mg/mL in DMSO with gentle warming and ultrasonic
外見 :
A crystalline solid
色:
Light yellow to yellow

安全性情報

MRT67307 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

MRT67307 化学特性,用途語,生産方法

説明

MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively). Through its effects on ULK1, MRT68921 blocks autophagy in cells, driving the accumulation of stalled early autophagosomal structures.

使用

MRT68921 dihydrochloride has been used:
  • as a specific inhibitor of Unc-51-like kinase 1 (ULK1) in SH-SY5Y neuroblastoma cells
  • as an inhibitor of ULK1 and ULK2 kinases in intrahepatic lymphocytes
  • as a ULK1 inhibitor to test its effect on attenuation of autophagosome accumulation in ubiquitin-specific peptidase 24 (USP24)?knockdown containing human neuroglioma H4 cells

Biochem/physiol Actions

MRT68921 is cytotoxic and acts on oxidative stress signals to kill cancer cells, making it an effective tumor therapy agent.

MRT67307 上流と下流の製品情報

原材料

準備製品

MRT67307 生産企業

Global( 44)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32836 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29821 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097
info@topbiochem.com China 9465 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7887 56

  スペクトルデータ(1HNMR)

MRT67307(1190379-70-4)1HNMR
  • 1190379-70-4
  • MRT68921(HCl)
  • MRT68921(HCI)
  • N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide
  • MRT68921 (free base)
  • Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-
  • N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)prop
  • MRT68921;MRT-68921;MRT 68921
  • N-(3-((5-cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide
  • N-(3-((5-Cyclopropyl-2-((2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide , MRT68921
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