8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル

8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1997	Ro 15-4513	91917-65-6	10mg	￥52000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1997	Ro 15-4513	91917-65-6	50mg	￥191000	2024-03-01	購入
Sigma-Aldrich Japan	R109	solid Ro 15-4513 solid	91917-65-6	25mg	￥96000	2024-03-01	購入
Sigma-Aldrich Japan	R109	solid Ro 15-4513 solid	91917-65-6	100mg	￥318000	2024-03-01	購入

8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル 化学特性,用途語,生産方法

説明

Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.

化学的特性

Off-white solid

使用

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

主な応用

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

生物活性

High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル 上流と下流の製品情報

原材料

準備製品

8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58

91917-65-6(8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル)キーワード:

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• 91917-65-6
• RO 15-4513
• 8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER
• ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE
• 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester
• 8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
• Azidomazenil
• Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester
• 4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
• Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
• RO 15-4513 ETHANOL ANTAGONIST
• Ro15 4513,Ro154513,Ro-15-4513
• 8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル
• Ro-15-4513
• エチル 12-アジド-8-メチル-9-オキソ-2,4,8-トリアザトリシクロ[8.4.0.02,6]テトラデカ-1(14),3,5,10,12-ペンタエン-5-カルボキシラート
• ベンゾジアゼピン系抗不安薬