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t-ブチルヒドロキシアニソール

t-ブチルヒドロキシアニソール 化学構造式
25013-16-5
CAS番号.
25013-16-5
化学名:
t-ブチルヒドロキシアニソール
别名:
エムバノックス;テノックスBHA;アンチオキシンB;ブチル化ヒドロキシアニソール【general】;tert-ブチルヒドロキシアニソール【general】;ブチル化ヒドロキシアニソール;tert-ブチル-4-メトキシフェノール;t-ブチルヒドロキシアニソール;2(3)-TERT-ブチル-4-メトキシフェノール;TERT-ブチル-4-ヒドロキシアニソール標準品;ブチレイテッドヒドロキシアニソール;tブチルヒドロキシアニソル;BHA;tert-ブチルヒドロキシアニソール;ブチルヒドロキシアニソール(BHA);ブチルヒドロキシアニソール(別名 BHA);ブチルヒドロキシアニソ-ル;ブチル化ヒドロキシアニソール (BHA);ターシャリ‐ブチル‐4‐メトキシフェノール;TERT‐ブチル‐4‐ヒドロキシアニソール標準品
英語化学名:
Butylated hydroxyanisole
英語别名:
BHA;BOA;E320;protex;embanox;tenoxbha;FEMA 2183;sustane1f;antioxyneb;eecno.e320
CBNumber:
CB2337887
化学式:
C11H16O2
分子量:
180.24354
MOL File:
25013-16-5.mol

t-ブチルヒドロキシアニソール 物理性質

融点 :
58-60 °C(lit.)
沸点 :
264-270°C
比重(密度) :
0.9976 (rough estimate)
蒸気密度:
6.2 (vs air)
屈折率 :
1.4910 (estimate)
FEMA :
2183 | BUTYLATED HYDROXYANISOLE
闪点 :
>230 °F
貯蔵温度 :
2-8°C
溶解性:
Practically insoluble in water; soluble in methanol; freely soluble in ≥50% aqueous ethanol, propylene glycol, chloroform, ether, hexane, cottonseed oil, peanut oil, soybean oil, glyceryl monooleate, and lard, and in solutions of alkali hydroxides.
外見 :
Crystalline Flakes or Crystals
色:
White to pale yellow
水溶解度 :
<0.1 g/100 mL at 18.5 ºC
Merck :
14,1547
安定性::
Stable, combustible. Incompatible with oxidizing agents, ferric salts. Degrades on long exposure to sunlight.
InChIKey:
WYEIRNDSZQKIDQ-UHFFFAOYSA-N
EPAの化学物質情報:
Phenol, (1,1-dimethylethyl)-4-methoxy- (25013-16-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-40-36/37/38-51/53
Sフレーズ  36/37-36/37/39-26-61-29
RIDADR  2811
WGK Germany  2
RTECS 番号 SL1945000
自然発火温度 599 °F
TSCA  Yes
HSコード  29093090
有毒物質データの 25013-16-5(Hazardous Substances Data)
毒性 LD50 in mice, rats (mg/kg): 2000, 2200 orally (Lehman)
化審法 一般化学物質
PRTR法 第1種指定化学物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P281 指定された個人用保護具を使用すること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。
P405 施錠して保管すること。

t-ブチルヒドロキシアニソール 価格 もっと(23)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-087S ブチル化ヒドロキシアニソール (BHA)BHA
Butylated hydroxyanisole (BHA), 100 ug/mL in MeOH
25013-16-5 1mL ¥3700 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSALR-087N ブチル化ヒドロキシアニソール (BHA)
Butylated Hydroxyanisole (BHA)
25013-16-5 100mg ¥4000 2018-12-26 購入
関東化学株式会社(KANTO) 23523-1A ブチレイテッドヒドロキシアニソール 96%
Butylated hydroxyanisole 96%
25013-16-5 100g ¥4000 2018-12-13 購入
関東化学株式会社(KANTO) 23523-2A ブチレイテッドヒドロキシアニソール 96%
Butylated hydroxyanisole 96%
25013-16-5 500g ¥13300 2018-12-13 購入
Sigma-Aldrich Japan 78943 ブチルヒドロキシアニソール analytical standard
Butylated hydroxyanisole analytical standard
25013-16-5 500mg ¥12900 2018-12-25 購入

t-ブチルヒドロキシアニソール MSDS


3(2)-tert-Butyl-4-hydroxyanisole

t-ブチルヒドロキシアニソール 化学特性,用途語,生産方法

外観

白色〜わずかにうすい黄褐色, 結晶〜結晶性粉末

定義

BHAは、ブチルヒドロキシアニソールの表示名称である。本品は4-メトキシフェノールにt-ブチル基が置換したものの混合物である。主に3-t-ブチル-4-ヒドロキシアニソールからなり、少量の2-t-ブチル-4-ヒドロキシアニソールを含み、次の化学式で表される。

溶解性

エタノール(95 )及びアセトンに極めて溶けやすく、水にほとんど溶けない。

用途

プラスチック添加用酸化防止剤,食品添加物

化粧品の成分用途

酸化防止剤、香料

化学的特性

white or light yellow waxy solid with an

化学的特性

Log Kow 5. 3. Values above 3.0 are likely to bioaccumulate in aquatic organisms

化学的特性

Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.

化学的特性

BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. Chemically, BHA is a mixture of two isomers, 3-tertiary-butyl-4-hydroxyanisole (90%) and 2-tertiary-butyl-4-hydroxyanisole (10%). Both BHA and BHT assert a good carry-through effect, although BHA is slightly better than BHT in this respect. BHT is, however, more effective in suppressing oxidation of animal fats than vegetable oils. Among its multiple applications, BHA is particularly useful in protecting the flavors and color of essential oils and is considered the most effective of all food-approved antioxidants for this application. BHA is particularly effective in controlling the oxidation of short-chain fatty acids, such as those found in coconut and palm kernel oils that are used typically in cereal and confectionary products.

天然物の起源

BHA is not known to occur as a natural product.

使用

BHA (butylated hydroxy anisole) is a preservative with anti-oxidant capabilities, not to be confused with beta hydroxy acids (BHAs).

使用

Butylated Hydroxyanisole (BHA) is an antioxidant that imparts stability to fats and oils and should be added before oxidation has started. It is a mixture of 3-tert-butyl-4-hydroxyanisole and 2-tertbutyl-4-hydroxyanisole. In direct addition, the fat or oil is heated to 60–70°C and the BHA is added slowly under vigorous agitation. The maximum concentration is 0.02% based on the weight of the fat or oil. It may protect the fat-soluble vitamins A, D, and E. It is used singly or in combination with other antioxidants. It is used in cereals, edible fat, vegetable oil, confectionary products, and rice.

使用

Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.

使用

Antioxidant and preservative, especially in foods, cosmetics, pharmaceuticals; also rubber and petroleum products.

調製方法

Prepared by the reaction of p-methoxyphenol with isobutene.

定義

A mixture of 2- and 3-tert-4-methoxyphenol.

Aroma threshold values

Detection: 3 ppm

一般的な説明

White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.

空気と水の反応

Insoluble in water.

反応プロフィール

Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.

危険性

Toxic by ingestion. Use in foods restricted; consult FDA regulations.

火災危険

Butylated hydroxyanisole is combustible.

応用例(製薬)

Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
Japanese regulations allow up to 1 g/kg in animal fats.

接触アレルゲン

BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes

安全性

Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
LD50 (mouse, oral): 1.1–2.0 g/kg
LD50 (rabbit, oral): 2.1 g/kg
LD50 (rat, IP): 0.88 g/kg
LD50 (rat, oral): 2.0 g/kg

Chemical Synthesis

Several methods are used for the commercial production of BHA. Methylation of hydroquinone yields an intermediate that gives a mixture of 3-BHA and 2-BHA upon treatment with tert-butyl alcohol and phosphoric acid. Butylation of hydroquinone and subsequent methylation with dimethyl sulfate and sodium hydroxide can also be used to produce a mixture of the two BHA isomers. In addition BHA can be synthesized by the tert-butylation of 4-methoxyphenol over silica or alumina at 150°C.

貯蔵

Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required

不和合性

Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.

廃棄物の処理

Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.

規制状況(Regulatory Status)

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

t-ブチルヒドロキシアニソール 上流と下流の製品情報

原材料

準備製品


t-ブチルヒドロキシアニソール 生産企業

Global( 233)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4660 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 746 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58

25013-16-5(t-ブチルヒドロキシアニソール)キーワード:


  • 25013-16-5
  • 2,2-dimethylpropane:4-methoxyphenol
  • E320
  • Butylhydroxyanisole(mixture of isomers)
  • T-BUTYL-4-HYDROXYANISOLE
  • T-BUTYL-4-METHOXYPHENOL
  • TERT BUTYLHYDROXYANISOLE
  • TERT-BUTYL-4-HYDROXYANISOLE
  • (1,1-dimethylethyl)-4-methoxy-pheno
  • (1,1-dimethylethyl)-4-methoxyphenol
  • (1,1-dimethylethyl)-4-methoxy-Phenol
  • FEMA 2183
  • HYDROXYANISOLE BUTYLATED
  • BHA
  • BHA: 2[3]-T-BUTYL-4-HYDROXYANISOLE
  • BUTYLATED HYDROXYANISOLE
  • BUTYLHYDROXYANISOLE
  • 2- AND 3-TERT-BUTYL-4-METHOXYPHENOL
  • 3(2)-T-BUTYL-4-HYDROXYANISOLE
  • 3(2)-TERT-BUTYL-4-HYDROXYANISOLE
  • 2-TERT-BUTYL-4-METHOXYPHENOL
  • 2,(3)-TERT-BUTYL-4-HYDROXYANISOLE
  • 2(3)-TERT-BUTYL-4-METHOXYPHENOL
  • 2+3-TERT-BUTYL-4-METHOXYPHENOL
  • 2(3)-t-Butyl-4-hydroxyanisole
  • 2(3)-t-Butylhydroquinone monomethyl ether
  • BOA
  • Butylated hydroxyanisoleBHA2(3)-tert-Butyl-4-methoxyphenol3(2)-tert-Butyl-4-hydroxyanisole
  • butylhydroxyanisole standard(mixture of isomers)
  • 2(3)-t-Butylhydroquinone monomethyl ether BHA
  • Butylated hydroxyanisole ,98.5%
  • エムバノックス
  • テノックスBHA
  • アンチオキシンB
  • ブチル化ヒドロキシアニソール【general】
  • tert-ブチルヒドロキシアニソール【general】
  • ブチル化ヒドロキシアニソール
  • tert-ブチル-4-メトキシフェノール
  • t-ブチルヒドロキシアニソール
  • 2(3)-TERT-ブチル-4-メトキシフェノール
  • TERT-ブチル-4-ヒドロキシアニソール標準品
  • ブチレイテッドヒドロキシアニソール
  • tブチルヒドロキシアニソル
  • BHA
  • tert-ブチルヒドロキシアニソール
  • ブチルヒドロキシアニソール(BHA)
  • ブチルヒドロキシアニソール(別名 BHA)
  • ブチルヒドロキシアニソ-ル
  • ブチル化ヒドロキシアニソール (BHA)
  • ターシャリ‐ブチル‐4‐メトキシフェノール
  • TERT‐ブチル‐4‐ヒドロキシアニソール標準品
  • ブチルヒドロキシアニソール
  • ブチルヒドロキシアニソール標準品(異性体混合物)
  • ブチル化ヒドロキシアニソール (BHA)BHA
  • ブチル化ヒドロキシアニソール (BHA)BHA, 100 µg/mL in MeOH
  • 2(3)-tert-ブチル-4-メトキシフェノール, 96%
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