デソゲストレル
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- CAS番号.
- 54024-22-5
- 化学名:
- デソゲストレル
- 别名:
- デソゲストレル;(17R)-13-エチル-11-メチレン-18,19-ジノルプレグナ-4-エン-20-イン-17-オール;13-エチル-11-メチレン-18,19-ジノル-17α-プレグナ-4-エン-20-イン-17-オール;(1R,3aS,3bS,9aR,9bS,11aS)-11a-エチル-1-エチニル-10-メチリデン-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-オール
- 英語名:
- Desogestrel
- 英語别名:
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
- CBNumber:
- CB2359630
- 化学式:
- C22H30O
- 分子量:
- 310.47
- MOL File:
- 54024-22-5.mol
- MSDS File:
- SDS
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デソゲストレル 物理性質
- 融点 :
- 109-110°C
- 比旋光度 :
- D20 +55° (chloroform)
- 沸点 :
- 390.62°C (rough estimate)
- 比重(密度) :
- 1.0169 (rough estimate)
- 屈折率 :
- 1.5100 (estimate)
- 貯蔵温度 :
- -20°C Freezer
- 溶解性:
- 水にほとんど溶けず、メタノールに溶けやすく、無水エタノールとジクロロメタンに溶けます。
- 酸解離定数(Pka):
- 13.07±0.40(Predicted)
- 色:
- White to Almost white
- Merck :
- 14,2926
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCD296875 |
デソゲストレル
Desogestrel |
54024-22-5 |
10mg |
￥33900 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCD296875 |
デソゲストレル
Desogestrel |
54024-22-5 |
5mg |
￥20900 |
2023-06-01 |
購入 |
|
東京化成工業
|
D4163 |
デソゲストレル >98.0%(HPLC)
Desogestrel
>98.0%(HPLC) |
54024-22-5 |
100mg |
￥16100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
Y0000510 |
システム適合性用デソゲストレル European Pharmacopoeia (EP) Reference Standard
Desogestrel for system suitability European Pharmacopoeia (EP) Reference Standard |
54024-22-5 |
y0000510 |
￥19400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1173235 |
デソゲストレル United States Pharmacopeia (USP) Reference Standard
Desogestrel United States Pharmacopeia (USP) Reference Standard |
54024-22-5 |
100mg |
￥71200 |
2024-03-01 |
購入 |
デソゲストレル 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
避妊薬, プロゲステロン受容体作動薬
説明
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity,
ex vivo in human lymphocytes and CD8
+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
化学的特性
White Solid
使用
A progestogen with low androgenic potency
一般的な説明
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
臨床応用
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
デソゲストレル 上流と下流の製品情報
原材料
準備製品
デソゲストレル 生産企業
Global( 318)Suppliers
54024-22-5(デソゲストレル)キーワード:
- 54024-22-5
- (17α)-13-Ethyl-11-methylene-18，19-dinorpregn-4-en-20-yn-17-ol
- (8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- (17R)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
- (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- Desogestrel (50 mg)
- DESTODENE
- Desogestrel for system suitability, European Pharmacopoeia (EP) Reference Standard
- Desogestrel, >=99%
- (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-Methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
- 13-ethyl-11-methylene-19-dinorpregn-4-en-20-yn-17-o(17-alpha)-1
- org2969
- 13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
- DESOGESTREL
- (17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
- Cerazette
- Cyclosa
- Dicromil
- Marvelon 150/320
- 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17.alpha.)-
- (17β)-13-Ethyl-11-methylene-19-nor-pregn-4-en-20-yn-17-ol
- DESOGESTRAL
- 13-Ethyl-11-methylene-18,19-dinor-17α-4-pregnen-20-yn-17-ol
- 13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- Desogestrel, 99%, a third-generation 19-nortestosterone derivative progestogen
- Desogestrel Solution
- Desogestrel>
- Desogestrelum
- 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17α)-
- Desogestrel USP/EP/BP
- DesogestrelQ: What is
Desogestrel Q: What is the CAS Number of
Desogestrel Q: What is the storage condition of
Desogestrel Q: What are the applications of
Desogestrel
- デソゲストレル
- (17R)-13-エチル-11-メチレン-18,19-ジノルプレグナ-4-エン-20-イン-17-オール
- 13-エチル-11-メチレン-18,19-ジノル-17α-プレグナ-4-エン-20-イン-17-オール
- (1R,3aS,3bS,9aR,9bS,11aS)-11a-エチル-1-エチニル-10-メチリデン-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-オール
- 黄体ホルモン
- 経口避妊薬