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メトキシクロル

メトキシクロル 化学構造式
72-43-5
CAS番号.
72-43-5
化学名:
メトキシクロル
别名:
メトキシクロル;マルラート;p,p'-メトキシクロル;1,1'-(2,2,2-トリクロロエチリデン)ビス(4-メトキシベンゼン);モキシエ;ジアニシルトリクロルエタン;1,1,1-トリクロロ-2,2-ビス(p-メトキシフェニル)エタン;1,1,1-トリクロロ-2,2-ビス(4-メトキシフェニル)エタン;4,4'-(2,2,2-トリクロロエチリデン)ビスアニソール;メトキシ-DDT;ジメトキシ-DT;メトキシクロル標準品;メトキシクロール;1,1,1-トリクロロ-2,2-ビス(4-メトキシフェニル)エタン (メトキシクロル);1,1-ビス(4-メトキシフェニル)-2,2,2-トリクロロエタン;ジメトキシジフェニルトリクロロエタン;1,1,1‐トリクロロ‐2,2‐ビス(4‐メトキシフェニル)エタン(別名 メトキシクロル);メトキシクロール標準品;CS_N-12403-100MG_メトキシクロル;P,P'-メトキシクロル STANDARD
英語化学名:
METHOXYCHLOR
英語别名:
DMDT;Metox;Moxie;MeOCl;mezoxk;oms466;Methoxo;Mezox K;DMDT(R);Marlate
CBNumber:
CB2393731
化学式:
C16H15Cl3O2
分子量:
345.6481
MOL File:
72-43-5.mol

メトキシクロル 物理性質

融点 :
86-88 °C(lit.)
沸点 :
346 °C
比重(密度) :
1.41 g/cm3 (25℃)
蒸気圧:
Very low
闪点 :
11 °C
貯蔵温度 :
APPROX 4°C
溶解性:
Soluble in ethanol (Windholz et al., 1983), chloroform (440 g/kg), xylene (440 g/kg), and methanol (50 g/kg) (Worthing and Hance, 1991)
外見 :
crystalline
水溶解度 :
0.1 mg l-1 (25 °C)
色:
yellow
Merck :
14,5990
BRN :
2057367
暴露限界値:
NIOSH REL: IDLH 5,000 mg/m3; OSHA PEL: TWA 15 mg/m3; ACGIH TLV: TWA 10 mg/m3.
安定性::
Stable, but light sensitive. Combustible at high temperature. Corrodes aluminium and iron slowly.
CAS データベース:
72-43-5(CAS DataBase Reference)
IARC:
3 (Vol. 20, Sup 7) 1987
EPAの化学物質情報:
Methoxychlor (72-43-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,T,F,N
Rフレーズ  20/21/22-40-39/23/24/25-23/24/25-11-67-65-50/53-38
Sフレーズ  7-23-36/37/39-45-16-62-61-60-33-29-9-36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS 番号 KJ3675000
国連危険物分類  9
容器等級  III
毒性 LD50 orally in rats: 5.0 g/kg (Hodge)
安衛法 57,57-2
PRTR法 第二種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H304 飲み込んで気道に侵入すると生命に危険のおそ れ 吸引性呼吸器有害性 1 危険
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P331 無理に吐かせないこと。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

メトキシクロル 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSAPP-9-127 メトキシクロル
Methoxychlor, 100 ug/mL in MeOH
72-43-5 1mL ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSAS-E0952 p,p'-メトキシクロル Standard
p,p'-Methoxychlor Standard, 1000 ug/mL in MeOH
72-43-5 1mL ¥11800 2018-12-26 購入
東京化成工業 M1736 メトキシクロル >95.0%(GC)
Methoxychlor >95.0%(GC)
72-43-5 25g ¥7500 2018-12-04 購入
関東化学株式会社(KANTO) 49802-50 メトキシクロール標準品
Methoxychlor standard
72-43-5 100mg ¥8000 2018-12-13 購入
Sigma-Aldrich Japan 36161 メトキシクロル PESTANAL?, analytical standard
Methoxychlor PESTANAL?, analytical standard
72-43-5 100mg ¥5300 2018-12-25 購入

メトキシクロル 化学特性,用途語,生産方法

外観

白色, 結晶性粉末~粉末

溶解性

水に難溶 (0.1 g/1l水), 芳香族系, 塩素系, ケトン系溶媒に易溶, その他多くの有機溶剤と混和。水0.1mg/l(25℃)。芳香族, 塩素化, ケトン系,植物油などの溶媒に易溶。クロロホルム, キシレン440, メタノール50(全てg/kg22℃)。

用途

農薬(殺虫剤)

用途

メトキシクロル試験用標準品。

農薬用途

殺虫剤

説明

Methoxychlor is a structural analogue of DDT but is not as persistent in the environment as DDT.

化学的特性

Methoxychlor is a colourless or pale yellow, crystalline synthetic organochlorine insecticide with mild fruity odour. It is available in the form of powder or crystals. Methoxychlor is moderately soluble in water and is soluble in a variety of organic solvents.

物理的性質

White to gray, or pale yellowish-orange crystals or powder. Nonflammable but may be combustible if dissolved in a flammable organic solvent or petroleum distillate for application. Pungent to mild, fruity odor. Odor threshold concentration in water is 4.7 mg/kg (quoted, Keith and Walters, 1992).

使用

Insecticide used to control mosquito larvae, house flies and other insect pests in field crops, fruits and vegetables; to control ecto-parasites on cattle, sheep and goats; recommended for use in dairy barns.

使用

Insecticide effective against mosquito larvae and house flies; recommended for use in dairy barns.

一般的な説明

METHOXYCHLOR is a white crystalline solid which is often dissolved in a liquid carrier such as diesel oil. METHOXYCHLOR can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. If dissolved in a liquid carrier, METHOXYCHLOR can easily penetrate the soil and contaminate groundwater and nearby streams. METHOXYCHLOR is used as a pesticide.

空気と水の反応

Insoluble in water.

反応プロフィール

METHOXYCHLOR turns pink or tan on exposure to light. METHOXYCHLOR is incompatible with alkaline materials, especially in the presence of catalytically-active metals. METHOXYCHLOR is slightly corrosive to iron and aluminum. METHOXYCHLOR is decomposed by refluxing with sodium in isopropyl alcohol. METHOXYCHLOR is also incompatible with strong oxidizers. METHOXYCHLOR will attack some forms of plastics, rubber and coatings. .

危険性

Toxic material. Liver damage and central nervous system impairment. Questionable carcinogen.

健康ハザード

Toxicity is relatively low. Inhalation or ingestion causes generalized depression.

健康ハザード

Low toxicity; acute and chronic effects aremuch less serious than those of the structurally similar DDT; skin absorption low;may cause kidney damage on chronic exposure; oral LD50 value (rats): 6000 mg/kg(ACGIH 1986); no evidence of carcinogenicity to animals or humans; exposure limit:TLV-TWA 10 mg/m3 (ACGIH, MSHA, andOSHA); RCRA Waste Number U247
Methoxychlor is a reproductive toxicant.Exposure of young adult male rats to methoxychlor reduced their serum testosterone levels (Murono et al. 2006). It metabolized in theliver into 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane and both methoxychlor and itsmetabolite were found to exhibit weak estrogenic and antiandrogenic activities. Flynnet al. (2005) have reported that long-termexposure to methoxychlor in diet altered thesexually dimorphic behavior in young ratsof both sexes. The study indicated that consumption of sodium solution increased in ratsfrom such exposure. The toxicity of methoxychlor, particularly in the central nervous system, may be attributed to its inhibition of brainmitochondrial respiration which probably iscaused by an increased production of reactiveoxygen species (Schuh et al. 2005).

火災危険

Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride gas may be formed in fire.

农业用途

Insecticide: Not approved for use in EU countries . Not registered for use in the U.S. There are 33 global suppliers . The U.S. EPA lists 826 active and/or canceled products containing methoxychlor. Methoxychlor was introduced as an insecticide in 1945. It is a close relative of DDT and has been increasing in use since the ban on DDT in 1972 because of its very low mammalian toxicity for home and garden, on domestic animals for fly control, for elm bark-beetle vectors of Dutch elm disease, and for blackfly larvae in streams. Methoxychlor is registered for about 87 crops such as alfalfa; nearly all fruits and vegetables, corn, wheat, rice, and other grains; beef and dairy cattle; and swine, goats and sheep, and for agricultural premises and outdoor fogging. It is available in wettable and dust powders, emulsifiable concentrates, granules, and as an aerosol. It is combined in formulations with malathion, parathion, piperonyl butoxide, and pyrethrins.

製品名

CHEMFORM®; HIGALMETOX®; MARLATE®; METOX®; MOXIE®; PRENTOX®

安全性プロファイル

Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl-. See also DDT and CHLOROPHENOLS.

Carcinogenicity

Female mice fed up to 2000mg/kg and males given 3500 mg/kg in the diet for 78 weeks showed no statistically significant increase in the incidence of benign and malignant tumors that could be attributed to methoxychlor.10 Chronic feeding studies in rats, at 850 and 1400mg/kg for males and females, respectively, also showed no significant carcinogenic responses, although high tumor rates in controls may have masked detection.10 Based on NCI results and several earlier animal studies, the IARC has determined that there is insufficient evidence that methoxychlor is carcinogenic in experimental animals and that it is not classifiable as to its carcinogenicity to humans.

環境運命予測

Biological. Degradation by the microorganism Aerobacter aerogenes under aerobic or anaerobic conditions yielded 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene and 1,1- dichloro-2,2-bis(p-methoxyphenyl)ethane (Mendel and Walton, 1966; Kobayashi and Rittman, 1982). Methoxychlor degrades at a faster rate in flooded/anaerobic soils than in nonflooded and aerobic soils (Fogel et al., 1982; Golovleva et al., 1984). In anaerobic soil, 90% of the applied dosage was lost after 3 months. In aerobic soil, only 0.3% was lost as carbon dioxide after 410 days (Fogel et al., 1982). In a modified river die-away test, methoxychlor underwent aerobic biodegradation at a rate of 0.0024/hour which corresponds to a half-life of 12 days (Cripe et al., 1987).
In a model aquatic ecosystem, methoxychlor degraded to ethanol, dihydroxyethane, dihydroxyethylene and unidentified polar metabolites (Metcalf et al., 1971). Kapoor et al. (1970) also studied the biodegradation of methoxychlor in a model ecosystem contain
From the first-order biotic and abiotic rate constants of methoxychlor in estuarine water and sediment/water systems, the estimated biodegradation half-lives were 208–8,837 and 12–45 days, respectively (Walker et al., 1988).
Paris and Lewis (1976) reported that the microorganism Aspergillis sp. accumulated methoxychlor slowly, requiring 16 hours to reach equilibrium. Some microorganisms, such as Flavobacterium harrisonii, Bacillus subtilis and Chlorella pyrenoidoda accumulated methoxychlor and reached equilibrium in only 30 minutes.
Groundwater. According to the U.S. EPA (1986) methoxychor has a high potential to leach to groundwater.

代謝経路

Upon UV irradiation with methyl oleate, methoxychlor is extensively added to the carbon ? carbon double bond of methyl oleate via radical mechanisms. Besides chlorinated stearic acids, several addition products are formed, offering new possibilities to produce bound residues in plants. The incubation of methoxychlor with liver microsomes from untreated and phenobarbital-treated rats and donors, in the presence of NADPH, yields three phenolic metabolites: monodemethylated and didemethylated methoxychlor and its hydroxylated (trihydroxy) methoxychlor. The metabolic route of methoxychlor by monooxygenases involves sequential demethylations to the dihydroxy derivative and a subsequent ring hydroxylation.

Solubility in water

Soluble in ethanol (Windholz et al., 1983), chloroform (440 g/kg), xylene (440 g/kg), and methanol (50 g/kg) (Worthing and Hance, 1991)

純化方法

Free the insecticide from 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane by crystallising from EtOH. It is dimorphic and also crystallises from Et2O/EtOH (m 92o). [Fritsch & Feldmann Justus Liebigs Ann Chem 306 77 1899, Smith et al. Aust J Chem 29 743 1976, Beilstein 6 H 1007.]

Degradation

Methoxychlor is stable to oxidising agents and to ultraviolet light but it becomes pink or tan-coloured on irradiation. It reacts with alkalis, especially in the presence of catalytic metals, with the loss of hydrogen chloride to give 1,l-dichloro-2,2-bis(4-methoxyphenyl)ethylene(2).
The major product of photolysis of methoxychlor in air-saturated water, irradiated at wavelengths >280 nm, was 2 while 1,1-dichloro-2,2-bis(4- methoxyphenyl)ethane (3) was formed along with 2 in degassed wateracetonitrile solutions. Subsequently, 2 was photolysed to benzaldehyde (Zepp et al., 1976). Products of photolysis in aqueous alcoholic solutions were 4,4’-dimethoxybenzophenone (4), 4-methoxybenzoic acid, and 4- methoxyphenol(5) (Wolfe et al., 1976). When methoxychlor was irradiated in milk by ultraviolet light (carbon arc, 220-330 nm) compounds 4 and 5, 4-methylanisole (6), 1,1,4,4-tetrakis(4-methoxyphenyl)-2,3-dichloro-2- butene (7) and 1,1,4,4-tetrakis(4-methoxyphenyl)-1,2,3-butatriene(8) were identified as products (Li and Bradley, 1969) (Scheme 1).
In water, chemical decomposition was slow and at 27 °C the DT50 at pH 5 to 9 was 100 days. Major products of hydrolysis are anisoin (9), anisil (10) and 2 (Wolfe et al., 1977) (see Scheme 2).

Toxicity evaluation

Acute oral LD50 for rats: 6,000 mg/kg

メトキシクロル 上流と下流の製品情報

原材料

準備製品


メトキシクロル 生産企業

Global( 68)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20535 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19233 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32444 55
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 400-660-8290 21-61259100-
86-21-61259102 sh@meryer.com China 40268 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15880 69
BEST-REAGENT 18981987031 400-1166-196
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com China 9897 57

72-43-5(メトキシクロル)キーワード:


  • 72-43-5
  • 1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane
  • 1-Methoxy-4-[2,2,2-trichloro-1-(4-methoxyphenyl)ethyl]benzene
  • 2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane
  • 2,2-Bis (p-methoxyphenol)-1,1,1-trichloroethane
  • 2,2-bis(p-anisyl)-1,1,1-trichloro-ethan
  • 2,2-Bis(p-anisyl)-1,1,1-trichloroethane
  • 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane
  • 2,2-Di(p-anisyl)-1,1,1-trichloroethane
  • 2,2-di-(p-methoxyphenyl)-1,1,1-trichloroethane
  • 2,2-Di(p-methoxyphenyl)-1,1,1-trichloroethane
  • 2,2-di-p-anisyl-1,1,1-trichloroethane
  • 4,4-(2,2,2-Trichloroethylidene)dianisole
  • 4,4’-(2,2,2-trichloroethylidene)dianisole
  • Benzene, 1,1'-(2,2,2-trichloroethylidene)bis*4-methoxy-
  • Benzene, 1,1'-(2,2,2-trichloroethylidene)bis[4-methoxy-
  • caswellno.550.
  • Methoxcide
  • Methoxo
  • Methoxychlor 2 ec
  • methoxychlor,[liquid]
  • methoxychlor,[solid]
  • methoxychlor,p,p’-
  • methoxychlor2ec
  • Methoxychlore
  • Metoksychlor
  • metoksychlor(polish)
  • Metox
  • Mezox K
  • mezoxk
  • Moxie
  • メトキシクロル
  • マルラート
  • p,p'-メトキシクロル
  • 1,1'-(2,2,2-トリクロロエチリデン)ビス(4-メトキシベンゼン)
  • モキシエ
  • ジアニシルトリクロルエタン
  • 1,1,1-トリクロロ-2,2-ビス(p-メトキシフェニル)エタン
  • 1,1,1-トリクロロ-2,2-ビス(4-メトキシフェニル)エタン
  • 4,4'-(2,2,2-トリクロロエチリデン)ビスアニソール
  • メトキシ-DDT
  • ジメトキシ-DT
  • メトキシクロル標準品
  • メトキシクロール
  • 1,1,1-トリクロロ-2,2-ビス(4-メトキシフェニル)エタン (メトキシクロル)
  • 1,1-ビス(4-メトキシフェニル)-2,2,2-トリクロロエタン
  • ジメトキシジフェニルトリクロロエタン
  • 1,1,1‐トリクロロ‐2,2‐ビス(4‐メトキシフェニル)エタン(別名 メトキシクロル)
  • メトキシクロール標準品
  • CS_N-12403-100MG_メトキシクロル
  • P,P'-メトキシクロル STANDARD
  • メトキシクロル STANDARD
  • p,p'-メトキシクロル Standard, 1000 µg/mL in MeOH
  • メトキシクロル Standard, 100 µg/mL in MeOH
  • メトキシクロル Standard, 1000 µg/mL in MeOH
  • メトキシクロル Standard, 2.0 ng/µL in Isooctane
  • メトキシクロル Standard, 200 ng/µL in Isooctane
  • メトキシクロル, 100 µg/mL in MeOH
  • 有機塩素系殺虫剤
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