フタリルスルファチアゾール 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗菌薬, 葉酸合成阻害薬
化学的特性
White or yellowish-white, crystalline powder.
使用
Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.
定義
ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.
製造方法
It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
世界保健機関（WHO）
Phthalylsulfathiazole, a sulfonamide anti-infective agent, was
introduced in 1946 for the treatment of bacterial infections. The importance of
sulfonamides has subsequently decreased as a result of increasing bacterial
resistance and their replacement by antibiotics which are generally more active
and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the
gastrointestinal tract, is no longer recommended in some countries, it continues to
be used in others for the treatment of local intestinal infections, including bacterial
dysentery, and for pre-operative bowel preparation.
フタリルスルファチアゾール 上流と下流の製品情報
原材料
準備製品