スクシニルコエンザイムA ナトリウム塩
スクシニルコエンザイムA ナトリウム塩 物理性質
- 貯蔵温度 :
- -20°C
- 溶解性:
- PBS (pH 7.2): 10 mg/ml
- 外見 :
- A crystalline solid
スクシニルコエンザイムA ナトリウム塩 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
S1129 |
スクシニルコエンザイムA ナトリウム塩 ≥85%
Succinyl coenzyme A sodium salt ≥85% |
108347-97-3 |
5mg |
￥58400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
S1129 |
スクシニルコエンザイムA ナトリウム塩 ≥85%
Succinyl coenzyme A sodium salt ≥85% |
108347-97-3 |
25mg |
￥223000 |
2024-03-01 |
購入 |
スクシニルコエンザイムA ナトリウム塩 化学特性,用途語,生産方法
説明
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B
12 deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.
使用
Succinyl coenzyme A sodium salt has been used:
- for the nonenzymatic succinylation of lysine in vitro,
- as a substrate for adipic acid biosynthesis in recombinant E. coli
- in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
- as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)
純化方法
If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]
スクシニルコエンザイムA ナトリウム塩 上流と下流の製品情報
原材料
準備製品
スクシニルコエンザイムA ナトリウム塩 生産企業
Global( 29)Suppliers
108347-97-3(スクシニルコエンザイムA ナトリウム塩)キーワード:
- 108347-97-3
- SUCCINYL COENZYME A SODIUM SALT
- succinyl coenzyme A sodium
- coenzyme A succinyl derivative, trisodium salt
- Succinyl CoA, Li-salt
- Succinyl coenzyme A sodium salt >=85%
- Coenzyme A,S-(hydrogen butanedioate),sodium salt
- Coenzyme A, S-(hydrogenbutanedioate), sodium salt (9CI)
- スクシニルコエンザイムA ナトリウム塩