メナテトレノン 化学特性,用途語,生産方法
外観
黄色, 結晶性粉末～粉末
溶解性
ヘキサンに極めて溶けやすく、エタノール(99.5)にやや溶けやすく、2-プロパノールにやや溶けにくく、メタノールに溶けにくく、水にほとんど溶けない。
効能
止血薬, 骨粗鬆症治療薬
商品名
グラケー (エーザイ); ケイツー (エーザイ); ケイツー (エーザイ); ケイツー (サンノーバ)
使用上の注意
光によって分解する
説明
Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.
化学的特性
A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.
天然物の起源
Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.
製造方法
It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.
定義
ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.
一般的な説明
Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.
参考文献
https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone
メナテトレノン 上流と下流の製品情報
原材料
Naphthalene, 1,4-dimethoxy-2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl]- (9CI)
GERANYL GERANYL BROMIDE
ビタミン K3
準備製品