ジアセチル モノオキシム 化学特性,用途語,生産方法
外観
白色～うすい黄褐色又はだいだい色, 結晶～粉末又は塊
溶解性
水及びエタノールに溶けやすい。
用途
有機合成原料、臨床検査薬(尿素窒素)原料。
化学的特性
white crystals
使用
2,3-Butanedione monoxime is a reversible inhibitor of myosin ATPase. It is also used as a reagent for colorimetric determination of urea.
製造方法
Approximately 9 moles of ethyl nitrite are required for this preparation. The literature indicates a suitable apparatus for its generation.
In a well-ventilated hood, to freshly dried and distilled methyl ethyl ketone (620 gm, 8.6 moles) is added, with stirring, 40 ml of cone, hydrochloric acid. The temperature of the reaction system is raised to 40°C. Without delay the addition of ethyl nitrite is initiated and the flow of the reagent is regulated to such a rate that the reaction temperature never exceeds 55°C. About 1.5 hr are required for the addition. The ethanol formed in the reaction, as well as unreacted methyl ethyl ketone, is separated by distillation until the pot temperature just reaches 90°C.
The product is separated from the residue by rapid steam distillation. Virtually all of the product will be found in the first 5 liters of the distillate. The distillate is saturated with 1.5 kg of sodium chloride and cooled to 0°C. The product, which precipitates out, is filtered off. If necessary, the product may be recrystallized from water to afford 500 gm (58%), m.p. 76.5°C.
一般的な説明
Cream-colored powder.
空気と水の反応
Soluble in water.
反応プロフィール
2,3-Butanedione monoxime may react violently during vacuum distillation above 130 pascals.
火災危険
Flash point data for 2,3-Butanedione monoxime are not available, but 2,3-Butanedione monoxime is probably combustible.
安全性プロファイル
Poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.
ジアセチル モノオキシム 上流と下流の製品情報
原材料
準備製品