2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-

2254605-76-8

CAS番号.: 2254605-76-8

化学名:

别名:

英語名:: 2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-

英語别名:: MD001;MD001,MD-001;5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-

CBNumber:: CB25896510

化学式:: C25H18O5

分子量:: 398.41

MOL File:: 2254605-76-8.mol

物理性質

安全性情報

用途語

生産企業 7

2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- 物理性質

貯蔵温度 :: Store at -20°C

溶解性:: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml

外見 :: A crystalline solid

安全性情報

2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- 化学特性,用途語,生産方法

説明

MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ. It binds to PPARα and PPARγ (K_ds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It increases glucose consumption as well as expression of GLUT2 and GLUT4 in HepG2 and 3T3-L1 cells, respectively, in a concentration-dependent manner. MD001 (20 mg/kg) decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.

2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- 上流と下流の製品情報

原材料

準備製品

2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl- 生産企業

Global( 7)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24023	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5021	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58