ChemicalBook
Chinese english Germany Korea

セフピロム

セフピロム 化学構造式
84957-29-9
CAS番号.
84957-29-9
化学名:
セフピロム
别名:
セフピロム
英語化学名:
Cefpirome
英語别名:
Keitim;HR-810;CEFPIROME;Cefpiroma;Cerfpirome;Cefpiromum;CEFPIROME SULPHATE;Cefpiromum [latin];Cefpiroma [spanish];cefpirome sulfate sterile
CBNumber:
CB2673505
化学式:
C22H22N6O5S2
分子量:
514.58
MOL File:
84957-29-9.mol

セフピロム 物理性質

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38-42/43
Sフレーズ  22-26-36/37/39
毒性 LD50 in mice, rats (g/kg): 1.9-2.4, 1.9-2.15 i.v.; 3.8-4.2, 5.8-6.55 i.p. (Donaubauer, Mayer)

セフピロム 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

セフピロム 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

使用

Cephalosporin antibiotic Claforan

brand name

Cefrom (Hoechst-Roussel).

抗菌性

A semisynthetic aminothiazoyl cephalosporin formulated as the sulfate for parenteral administration. Activity against common pathogens is similar to that of cefotaxime and ceftriaxone, but it is more active against Ps. aeruginosa. Unlike other cephalosporins it exhibits activity against some strains of enterococci (MIC 4–16 mg/L), but this is of doubtful clinical benefit. It is generally very stable to β-lactamases. It is active against strains of Enterobacter spp., Citrobacter spp., Hafnia spp., Providencia spp., Ser. marcescens and Pr. vulgaris producing molecular class C cephalosporinases. Sten. maltophilia is resistant.
A 1 g intramuscular injection produces a plasma concentration of 25 mg/L after 1.6–2.3 h. A similar intravenous dose achieves a peak concentration of 97 mg/L. The plasma half- life is 1.4–2.3 h and protein binding is around 10%. It is well distributed, achieving therapeutic concentrations in tissues and exudates. It penetrates poorly into CSF in the absence of meningeal inflammation, but concentrations around 2–4 mg/L have been found in patients with purulent meningitis.
Little, if any, of the drug is metabolized and most is excreted unchanged in the urine within 12 h, mainly by glomerular filtration. Clearance declines in proportion to renal function. Around 60% of the drug is removed in 3 h by hemodialysis. Low concentrations are found in breast milk.
Side effects are those common to other cephalosporins. Diarrhea is common and occasional cases of pseudomembranous colitis have been reported.
It is mainly used in the treatment of serious sepsis, particularly nosocomial infections in which resistant Gram-negative pathogens are known or suspected to be involved. It is not widely available, but is marketed in Japan.

臨床応用

Cefpirome (Cefrom) is a newer parenteral, -lactamase–resistant cephalosporin with a quaternary ammonium groupat the 3-position of the cephem nucleus. Because its potencyagainst Gram-positive and Gram-negative bacteria rivals thatof the first-generation and third-generation cephalosporins,respectively, cefpirome is being touted as the first fourthgenerationcephalosporin. Its broad spectrum includesmethicillin-sensitive staphylococci, penicillin-resistantpneumococci, and β-lactamase–producing strains of E. coli,Enterobacter, Citrobacter, and Serratia spp. Its efficacyagainst P. aeruginosa is comparable with that of ceftazidime.Cefpirome is excreted largely unchanged in the urine with ahalf-life of 2 hours.

セフピロム 上流と下流の製品情報

原材料

準備製品


セフピロム 生産企業

Global( 75)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2214 55
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9103 52
Wuhan Fortuna Chemical Co., Ltd +86-27-59207852 85767163
+86-27-59524646 info@fortunachem.com China 2917 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12128 58
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 15618 56
Jintan WeiDeLong Chemical Co., Ltd. 0519-82805025;82196959;13616137378
0519-82805025 wangqiangcz@126.com China 4165 58

84957-29-9(セフピロム)キーワード:


  • 84957-29-9
  • Cerfpirome
  • CEFPIROME
  • CEFPIROME SULPHATE
  • 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5H-1-pyrindinium hydroxide, inner salt, 72-(Z)-(O-methyloxime)
  • 3-[(2,3-cyclopenteno-1-pyridinium)methyl]-7-[2-syn-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylate
  • HR-810
  • Keitim
  • (6R,7R)-7-(()-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-8-oxo-3-(2beta-trimethylenpyridinio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylat
  • 1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-1-pyridinium hydroxide, inner salt
  • 5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-5,6,7,8-tetrahydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
  • 5H-1-Pyrindinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
  • Cefpiroma
  • Cefpiroma [spanish]
  • Cefpiromum
  • Cefpiromum [latin]
  • cefpirome sulfate sterile
  • (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Sinomenine Solution, 100ppm
  • セフピロム
Copyright 2017 © ChemicalBook. All rights reserved