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ポロキサレン

ポロキサレン 化学構造式
9003-11-6
CAS番号.
9003-11-6
化学名:
ポロキサレン
别名:
ポリオキシエチレンポリオキシプロピレンブロックコポリマー;ポリオキシエチレンポリオキシプロピレングリコ-ル;ポロキサレン;プルロニックF68;エチレン=オキシド·プロピレン=オキシド重;ポロキサマー124;ポロキサマー181;ポロキサマー182;ポロキサマー184;ポロキサマー188;メロキサポール172;PEG/PPG-2000/200コポリマー;ポロキサマー331;ポロキサマー338;ポロキサマー407;PLURONIC® F-127 10%水溶液;SYNPERONIC(R) F108 PRACT.;SYNPERONIC(R) F68 PRACT.;PLURONIC® F-127;CULTURESURE® 10W/V% ポリオキシエチレンポリオキシプロピレングリコール溶液
英語化学名:
Polyethylene-polypropylene glycol
英語别名:
f98;L64;L31;F-38;P188;rc102;PEOPO;PE-8100;ene-poL;ypropyL
CBNumber:
CB2709101
化学式:
C5H10O2
分子量:
102.1317
MOL File:
9003-11-6.mol

ポロキサレン 物理性質

融点 :
57-61 °C
沸点 :
>200 °C(lit.)
比重(密度) :
1.095 g/mL at 25 °C
蒸気密度:
>1 (vs air)
蒸気圧:
<0.3 mm Hg ( 20 °C)
屈折率 :
n20/D 1.466
闪点 :
>230 °F
貯蔵温度 :
2-8°C
溶解性:
H2O: at <70 °Csoluble
外見 :
solution
色:
APHA: ≤120, 50/50 in CH3OH
PH:
5.0-7.5 (100g/L in H2O)
酸塩基指示薬変色域(pH):
5.0 - 7.5
水溶解度 :
Miscible with water.
極大吸収波長 (λmax):
λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
Merck :
13,7644
EPAの化学物質情報:
Poloxalene (9003-11-6)

安全性情報

主な危険性  T
Rフレーズ  21-23/24/25-25-36/37/38
Sフレーズ  23-24/25-45-36/37/39-26
WGK Germany  3
RTECS 番号 TP6164333
TSCA  Yes
HSコード  39059100
有毒物質データの 9003-11-6(Hazardous Substances Data)
毒性 LD50 oral in rabbit: 35gm/kg

ポロキサレン 価格 もっと(60)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01SEV35724 Synperonic(R) F68 pract.
Synperonic(R) F68, pract.
9003-11-6 100g ¥10300 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01SEV35724 Synperonic(R) F68 pract.
Synperonic(R) F68, pract.
9003-11-6 1kg ¥28000 2021-03-23 購入
Sigma-Aldrich Japan P2164030 European Pharmacopoeia (EP) Reference Standard
Poloxamer 407 European Pharmacopoeia (EP) Reference Standard
9003-11-6 ¥35200 2021-03-23 購入
Sigma-Aldrich Japan P2164021 European Pharmacopoeia (EP) Reference Standard
European Pharmacopoeia (EP) Reference Standard
9003-11-6 ¥35200 2021-03-23 購入
Sigma-Aldrich Japan P2164020 European Pharmacopoeia (EP) Reference Standard
European Pharmacopoeia (EP) Reference Standard
9003-11-6 ¥35200 2021-03-23 購入

ポロキサレン 化学特性,用途語,生産方法

外観

無色澄明の液体

定義

本品は、ポリオキシエチレン、ポリオキシプロピレンのブロック共重合体であり、次の化学式で表される。
x:平均128、y:平均54、z:平均128

溶解性

水及びエタノールに溶ける。

化粧品の成分用途

結合剤、抗菌剤、可溶化剤、親水性増粘剤、溶剤、乳化安定剤、乳化剤、洗浄剤

効能

抗炎症薬, 抗血栓薬

化学的特性

93%

化学的特性

Polyethylene-polypropylene glycol generally occur as white, waxy, free-flowing prilled granules, or as cast solids. They are practically odorless and tasteless. At room temperature, poloxamer 124 occurs as a colorless liquid.

Originator

Polykol ,Upjohn, US ,1958

使用

Polyethylene-polypropylene glycol is a liquid surfactant polymer.

使用

Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

使用

pyrethroid-based pesticide for use in mosquito control

調製方法

Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. Ethylene oxide is then added to form the block copolymer.

Manufacturing Process

(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide. The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved. Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380. The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered. The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.
(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide. 105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A). The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.

brand name

Lutrol F (BASF); Pluracare (BASF); Pluronic (BASF).

Therapeutic Function

Pharmaceutic aid (surfactant)

一般的な説明

Pluronic? L-81 is a lipoprotein secretion inhibitor.

応用例(製薬)

Polyethylene-polypropylene glycol is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Polyethylene-polypropylene glycol is  used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.

安全性プロファイル

When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Polyethylene-polypropylene glycol is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.Polyethylene-polypropylene glycol is  not metabolized in the body.
Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.
In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.
No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.
(mouse, IV): 1 g/kg
(mouse, oral): 15 g/kg
(mouse, SC): 5.5 g/kg
(rat, IV): 7.5 g/kg
(rat, oral): 9.4 g/kg

貯蔵

Polyethylene-polypropylene glycol is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth.
The bulk material should be stored in a well-closed container in a cool, dry place.

不和合性

Depending on the relative concentrations, poloxamer 188 is incompatible with phenols and parabens.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders, solutions, suspensions, and syrups; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ポロキサレン 上流と下流の製品情報

原材料

準備製品


ポロキサレン 生産企業

Global( 423)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 cathy@hnxtchem.com CHINA 293 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
BAODING STORD IMPORT AND EXPORT CO.,LTD
+8618603329229
+86-0312-8410000 luis.manager113@foxmail.com China 291 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9115 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58

9003-11-6(ポロキサレン)キーワード:


  • 9003-11-6
  • BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL
  • Poloxamer
  • POLOXAMER 184 NF
  • Polypropylene-polyethylene glycol: (Pluronic L-81)
  • PEG-PPG-PEG
  • Pluronic(R) L64, Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)
  • Synperonic(R) PE/L64
  • POLOXAMER 181 NF
  • polypropylene/ polyethylene glycol copolymer
  • POP/POE condensate
  • Oxirane, 2-methyl-, polymer with oxirane, ether with 1,2-propanediol (2:1)
  • Thanol E 4003
  • Poloxanlene 182
  • PEG-PPG-PEG [average MW (5800)]
  • SYNPERONIC L61PRACT.
  • SYNPERONIC F68PRACT.
  • SYNPERONIC F108PRACT.
  • Synperonic PE/L64,Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)
  • Polymer(ethylene oxide·propylene oxide)
  • PluronicF-68,Polyoxyethylene-polyoxypropylene block copolymer
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic F-68
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-31
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-35
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-61
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-81
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-64
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic L-121
  • Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),PEG-PPG-PEG, Pluronic P-123
  • Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol),PPG-PEG-PPG, Pluronic 10R5
  • Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol),PPG-PEG-PPG, Pluronic 17R4
  • ポリオキシエチレンポリオキシプロピレンブロックコポリマー
  • ポリオキシエチレンポリオキシプロピレングリコ-ル
  • ポロキサレン
  • プルロニックF68
  • エチレン=オキシド·プロピレン=オキシド重
  • ポロキサマー124
  • ポロキサマー181
  • ポロキサマー182
  • ポロキサマー184
  • ポロキサマー188
  • メロキサポール172
  • PEG/PPG-2000/200コポリマー
  • ポロキサマー331
  • ポロキサマー338
  • ポロキサマー407
  • PLURONIC® F-127 10%水溶液
  • SYNPERONIC(R) F108 PRACT.
  • SYNPERONIC(R) F68 PRACT.
  • PLURONIC® F-127
  • CULTURESURE® 10W/V% ポリオキシエチレンポリオキシプロピレングリコール溶液
  • PLURONICR F-127 20% DMSO溶液
  • ポリオキシエチレンポリオキシプロピレングリコール (160E.O.) (30P.O.)
  • プルロニックF-68R ポリオール
  • ポロキサマー LIQUID
  • PLURONIC F-127
  • ポロキサマー SOLID
  • プルロニック® F-127
  • ポリ(エチレングリコール)-BLOCK-ポリ(プロピレングリコール)-BLOCK-ポリ(エチレングリコール)
  • ポリ(プロピレングリコール)-BLOCK-ポリ(エチレングリコール)-BLOCK-ポリ(プロピレングリコール)
  • ベポロキサマー
  • PEG/PPG-1/2コポリマー
  • PEG/PPG-10/2コポリマー
  • PEG/PPG-10/70コポリマー
  • PEG/PPG-150/30コポリマー
  • PEG/PPG-160/31コポリマー
  • PEG/PPG-17/6コポリマー
  • PEG/PPG-18/4コポリマー
  • PEG/PPG-200/70コポリマー
  • PEG/PPG-23/17コポリマー
  • PEG/PPG-25/30コポリマー
  • PEG/PPG-26/31コポリマー
  • PEG/PPG-30/33コポリマー
  • PEG/PPG-300/55コポリマー
  • PEG/PPG-4/2コポリマー
  • PEG/PPG-5/30コポリマー
  • PEG/PPG-6/2コポリマー
  • PEG/PPG-7/50コポリマー
  • PEG/PPG-8/17コポリマー
  • ポロキサマー101
  • ポロキサマー105
  • ポロキサマー123
  • ポロキサマー185
  • ポロキサマー215
  • ポロキサマー217
  • ポロキサマー234
  • ポロキサマー235
  • ポロキサマー333
  • ポロキサマー335
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