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シタロプラム·臭化水素塩

シタロプラム·臭化水素塩 化学構造式
59729-32-7
CAS番号.
59729-32-7
化学名:
シタロプラム·臭化水素塩
别名:
シタロプラム臭化水素酸塩;シタロプラム·臭化水素塩;1-[3-(ジメチルアミノ)プロピル]-1-(4-フルオロフェニル)-1,3-ジヒドロ-5-イソベンゾフランカルボニトリル·臭化水素酸塩;シタロプラム·臭化水素酸塩;1-[3-(ジメチルアミノ)プロピル]-1-(4-フルオロフェニル)-1,3-ジヒドロイソベンゾフラン-5-カルボニトリル臭化水素酸塩;シタロプラム, 臭化水素酸塩;シタロプラム 臭化水素酸塩;シタロプラム 臭化水素酸塩 溶液
英語化学名:
Citalopram hydrobromide
英語别名:
ERDOSTEIN;Bonitrile HBr;Lu 10-171 HBr;Citalopran HBr;CITALOPRAM HBR;Citalopram-D4Br;CitalopraM HBr API;Citalopram HBr Salt;CITALOPRAM HYDROBROMIDE;Citalopramehydrobromide
CBNumber:
CB2736240
化学式:
C20H22BrFN2O
分子量:
405.3
MOL File:
59729-32-7.mol

シタロプラム·臭化水素塩 物理性質

融点 :
182-188°C
闪点 :
9℃
貯蔵温度 :
2-8°C
溶解性:
H2O: soluble (sparingly)
外見 :
powder
Merck :
14,2318
安定性::
Stable. Incompatible with strong oxidizing agents.
CAS データベース:
59729-32-7(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T
Rフレーズ  11-23/24/25-39/23/24/25-22
Sフレーズ  7-16-36/37-45-24/25
RIDADR  3249
WGK Germany  3
RTECS 番号 NP6313500
国連危険物分類  6.1(b)
容器等級  III
HSコード  29329990
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

シタロプラム·臭化水素塩 価格 もっと(20)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTC3477 シタロプラム臭化水素酸塩
Citalopram Hydrobromide
59729-32-7 25mg ¥19100 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01LKTC3477 シタロプラム臭化水素酸塩
Citalopram Hydrobromide
59729-32-7 100mg ¥61700 2021-03-23 購入
東京化成工業 C2370 シタロプラム臭化水素酸塩 >98.0%(HPLC)(T)
Citalopram Hydrobromide >98.0%(HPLC)(T)
59729-32-7 1g ¥11900 2021-03-23 購入
東京化成工業 C2370 シタロプラム臭化水素酸塩 >98.0%(HPLC)(T)
Citalopram Hydrobromide >98.0%(HPLC)(T)
59729-32-7 5g ¥41100 2021-03-23 購入
Sigma-Aldrich Japan Y0001008 European Pharmacopoeia (EP) Reference Standard
Citalopram hydrobromide European Pharmacopoeia (EP) Reference Standard
59729-32-7 ¥35200 2021-03-23 購入

シタロプラム·臭化水素塩 化学特性,用途語,生産方法

外観

白色~ほとんど白色粉末~結晶

用途

選択的セロトニン取り込み阻 害剤(SSRI)です。

用途

選択的セロトニン取り込み阻 害剤(SSRI)です。

効能

抗うつ薬, 選択的セロトニン再取り込み阻害薬

化学的特性

White or almost white, crystalline powder.

Originator

Celexa,Lundbeck, Forest

使用

Antidepressant;5HT uptake inhibitor

使用

Anti-depressant/Anti-psychotic

使用

An inhibitor of serotonin (5-HT) uptake. Used as an antidepressant

Manufacturing Process

5-Carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuranwas synthesized by three methods: 1. A solution of 1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3-dihydroisobenzofuran-5-yl magnesium bromide in dry THF (90 mL) (prepared by ordinary methods from 5-bromo-1-(4-fluorophenyl)-1-(3-
dimethylaminopropyl)-1,3-dihydro-isobenzofuran (9 g, 0.024 mole) and
magnesium (0.73 g, 0.03 mole)) was added to dry solid CO2 (50 g). After addition, the mixture was left at room temperature for 16 hours. The volatile materials were removed in vacuo and the residue was taken up in water (100 mL). pH was adjusted to 5.5 by adding HCl (aqueous, 4 N). The aqueous phase was extracted with toluene (100 mL). The toluene was removed in vacuo and the 5-carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran was obtained as oil. Yield 6 g.
2. To a solution of 5-bromo-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)- 1,3-dihydroisobenzofuran (9 g, 0.024 mole) in tertbutyl methyl ether (150 mL) was added n-BuLi (1.6 M in hexanes, 40 mL) at -78 to -65°C. The temperature of the solution was allowed to raise to -30°C over a period of 2 hours. The reaction mixture was added to dry solid CO2 (50 g). After addition, the mixture was left at room temperature for 16 hours. The volatile materials were removed in vacuo and the residue was taken up in water (100 mL). pH was adjusted to 5.5 by adding HCl (aqueous, 4 N). The aqueous phase was extracted with toluene (100 mL). The toluene was removed in vacuo and the 5-carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran was obtained as an oil. Yield 7.5 g.
3. n-BuLi (20 mL, 1.6 M in hexane) was added to a solution of isopropylmagnesium chloride (8.0 mL, 2 M in diethyl ether) in THF (25 mL) at 0°C. The resulting mixture was stirred at 0°C for 1 h, then cooled to -78°C and a solution of 5-bromo-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydro-isobenzofuran (5.0 g, 13.0 mmol) in THF (25 mL) was added. The mixture was allowed to warm to -10°C during 1 h, then cooled again to -78°C and CO2 (5.7 g, 130 mmol) was added. The mixture was allowed to warm to room temperature, and then evaporated. Ion exchange chromatography of the residue (Dowex RTM-50, acidic form) eluting with 1 M NH3 afforded the 5- carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran as a thick oil.
5-Carboxy-1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-1,3- dihydroisobenzofuran (5 g, 0.015 mole) and sulfamide (1.65 g, 0.017 mole) were dissolved in sulfolane (15 mL). Thionyl chloride (2.25 g, 0.019 mole) was added at room temperature and the temperature of the reaction mixture was raised to 130°C for 2 hours. The reaction mixture was allowed to cool to 75°C and water (25 mL) was added. The temperature was held at 75°C for 15 min, and then the reaction mixture was cooled to room temperature. pH was ajusted to 9 with ammonium hydroxide and then n-heptane (75 mL) was added. The temperature was raised to 70°C and the hot n-heptane layer was isolated from which the 5-cyano-1-(4-fluorophenyl)-1-(3- dimethylaminopropyl)-1,3-dihydroisobenzofuran (Citalopram, free base) crystallised on cooling. Yield 3.77 g. Purity (HPLC peak area) >97%. The hydrobromide was prepared in conventional manner and crystallized from isopropanol; melting point 148-150°C.

brand name

Celexa (Forest).

Therapeutic Function

Antidepressant

危険性

A poison.

シタロプラム·臭化水素塩 上流と下流の製品情報

原材料

準備製品


シタロプラム·臭化水素塩 生産企業

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59729-32-7(シタロプラム·臭化水素塩)キーワード:


  • 59729-32-7
  • Citalopran HBr
  • 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromi
  • Citalopram hydrobromide solution
  • Citalopram HBr Salt
  • 1-[3-(DIMETHYLAMINO)PROPYL]-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE HYDROBROMIDE
  • 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobr
  • CITALOPRAM HBR
  • (+/-)-CITALOPRAM HYDROBROMIDE
  • CITALOPRAM HYDROBROMIDE
  • Citalopram Hydrobromide (200 mg)
  • 1-(3-DiMethylaMino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5- carbonitrile hydrobroMide
  • CitalopraM HBr API
  • 5-Isobenzofurancarbonitrile, 1-[3-(diMethylaMino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, hydrobroMide
  • Citalopram hydrobromide, 95%, selective serotonin reuptake inhibitor (SSRI)
  • 5-ISOBENZOFURANCARBONITRILE, 1,3-DIHYDRO-1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-
  • Citalopram Hydrobromide Tablets
  • 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile monohydrobromide
  • 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-phthalancarbonitrilehydrobromide
  • Citalopramehydrobromide
  • Nitalapram, LU-10-171, 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dizohydro-5-isobenzofurancarbonitrile Hydrobromide Sal
  • 5-Isobenzofurancarbonitrile, 1-3-(dimethylamino)propyl-1-(4-fluorophenyl)-1,3-dihydro-, monohydrobromide
  • CITALOPRAM BROMOHYDRATE
  • Nitalapram, LU-10-171, 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dizohydro-5-isobenzofurancarbonitrile Hydrobromide Salt
  • 5-isobenzofurancarbonitrile,1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3
  • 1-(3-(Dimethylamino)-propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile, hydrobromide
  • ERDOSTEIN
  • Citalopram-D4Br
  • Citaloplam hydrobromide
  • CitalopraM HydrobroMide, USP
  • Citalopram hydrobromide,1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
  • シタロプラム臭化水素酸塩
  • シタロプラム·臭化水素塩
  • 1-[3-(ジメチルアミノ)プロピル]-1-(4-フルオロフェニル)-1,3-ジヒドロ-5-イソベンゾフランカルボニトリル·臭化水素酸塩
  • シタロプラム·臭化水素酸塩
  • 1-[3-(ジメチルアミノ)プロピル]-1-(4-フルオロフェニル)-1,3-ジヒドロイソベンゾフラン-5-カルボニトリル臭化水素酸塩
  • シタロプラム, 臭化水素酸塩
  • シタロプラム 臭化水素酸塩
  • シタロプラム 臭化水素酸塩 溶液
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