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(E)-2-ブテン二酸鉄(II)

(E)-2-ブテン二酸鉄(II) 化学構造式
141-01-5
CAS番号.
141-01-5
化学名:
(E)-2-ブテン二酸鉄(II)
别名:
(E)-2-ブテン二酸鉄(II);フマル酸第一鉄;フェルム;フマル酸鉄(II);フマル酸鉄;鉄(II)=フマラート;フマル酸鉄(Ⅱ);フマル酸第一鉄 (JAN)
英語化学名:
Ferrous fumarate
英語别名:
firon;fumar;ircon;galfer;cpiron;ferrone;fumafer;fumar-f;hemoton;palafer
CBNumber:
CB2739933
化学式:
C4H2FeO4
分子量:
169.9
MOL File:
141-01-5.mol

(E)-2-ブテン二酸鉄(II) 物理性質

融点 :
>280°C
比重(密度) :
2.435
溶解性:
Slightly soluble in water, very slightly soluble in ethanol (96 per cent).
外見 :
solid
水溶解度 :
Soluble in water (0.14 g/100 ml at 25°C).
Merck :
14,4046
安定性::
Stability
InChIKey:
PMVSDNDAUGGCCE-TYYBGVCCSA-L
CAS データベース:
141-01-5(CAS DataBase Reference)
EPAの化学物質情報:
2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)

安全性情報

Rフレーズ  36/37/38
Sフレーズ  22-36/37/39-24/25
WGK Germany  2
RTECS 番号 LT1950000
TSCA  Yes
HSコード  29171900
毒性 LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum)

(E)-2-ブテン二酸鉄(II) 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0109-0172 フマル酸鉄(II) 90.0+% (Titration)
Iron(II) Fumarate 90.0+% (Titration)
141-01-5 500g ¥12800 2021-03-23 購入
Sigma-Aldrich Japan F5381 フマル酸鉄(II) 97%
Iron(II) fumarate 97%
141-01-5 500g ¥8760 2021-03-23 購入
純正化学株式会社 64253-1201 フマル酸鉄(Ⅱ);フマル酸第一鉄 97%+
Iron(Ⅱ) fumarate;Ferrous fumarate 97%+
141-01-5 500g ¥4300 2021-03-22 購入

(E)-2-ブテン二酸鉄(II) MSDS


Iron(II) fumarate

(E)-2-ブテン二酸鉄(II) 化学特性,用途語,生産方法

外観

赤褐色の粉末

溶解性

熱希塩酸に溶け、水又はエタノールにほとんど溶けない。

用途

鉄強化剤研究用。

効能

貧血治療薬, 造血薬, 鉄補充薬

商品名

フェルム (日医工)

説明

Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.

化学的特性

§184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.

化学的特性

brown to reddish-brown powder

Originator

Toleron,Mallinckrodt Inc.,US,1957

使用

Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks.

使用

Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency.

定義

Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl

Manufacturing Process

Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.

Therapeutic Function

Hematinic

安全性プロファイル

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.

参考文献

Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.
Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.

(E)-2-ブテン二酸鉄(II) 上流と下流の製品情報

原材料

準備製品


(E)-2-ブテン二酸鉄(II) 生産企業

Global( 296)Suppliers
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141-01-5((E)-2-ブテン二酸鉄(II))キーワード:


  • 141-01-5
  • Iron(Ⅱ) fumarate
  • Iron(II) fuMarate >=97.0%
  • IR microencapsulated Ferrous fumarate
  • Ferrius fumarate
  • IRON(II) FUMARATE
  • IRON(+2)FUMARATE
  • IRON FUMARATE
  • FERROUS FUMARATE
  • FERROUS FUMERATE
  • ferrofume
  • ferronat
  • ferrone
  • ferrotemp
  • Ferroustrans-butenedioicacid
  • fersamal
  • Fersanmal
  • firon
  • fumafer
  • fumar
  • fumar-f
  • fumaricacid,iron(2+)salt(1:1)
  • galfer
  • hemoton
  • ircon
  • iron(2+)salt(1:1)
  • iron(2++)salt(1:1)
  • one-iron
  • palafer
  • toleron
  • tolferain
  • (E)-2-ブテン二酸鉄(II)
  • フマル酸第一鉄
  • フェルム
  • フマル酸鉄(II)
  • フマル酸鉄
  • 鉄(II)=フマラート
  • フマル酸鉄(Ⅱ)
  • フマル酸第一鉄 (JAN)
  • 鉄剤
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