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シルデナフィル

シルデナフィル 化学構造式
139755-83-2
CAS番号.
139755-83-2
化学名:
シルデナフィル
别名:
シルデナフィル;シルデナフィル;シルデナフィル 溶液
英語化学名:
Sildenafil
英語别名:
viagTa;Revatio;UK-92480;Sildefil;SIDANAFIL;SILDENAFIL;Sildenafile;+8617197824028;sildenafil BPC;Sildenafil(Viagra)
CBNumber:
CB2747316
化学式:
C22H30N6O4S
分子量:
474.58
MOL File:
139755-83-2.mol

シルデナフィル 物理性質

融点 :
187-189°C
比重(密度) :
1.39±0.1 g/cm3(Predicted)
闪点 :
9℃
貯蔵温度 :
Refrigerator
酸解離定数(Pka):
pKa 8.7 (Uncertain)
InChIKey:
BNRNXUUZRGQAQC-UHFFFAOYSA-N
CAS データベース:
139755-83-2(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi,T,F
Rフレーズ  36/37/38-39/23/24/25-23/24/25-11
Sフレーズ  22-24/25-36-26-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
HSコード  38220090
有毒物質データの 139755-83-2(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

シルデナフィル 価格 もっと(9)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CAY10008671
Sildenafil
139755-83-2 25mg ¥15000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CAY10008671
Sildenafil
139755-83-2 10mg ¥8500 2018-12-26 購入
Sigma-Aldrich Japan S-010 シルデナフィル 溶液 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
Sildenafil solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
139755-83-2 1ml ¥25100 2018-12-25 購入
富士フイルム和光純薬株式会社(wako) W01TRCS435001 シルデナフィル
Sildenafil
139755-83-2 100mg ¥250000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCS435001 シルデナフィル
Sildenafil
139755-83-2 5mg ¥12500 2018-12-26 購入

シルデナフィル 化学特性,用途語,生産方法

用途

シルデナフィル(Sildenafil)は、勃起不全 (ED) 、および肺動脈性肺高血圧症の治療薬である。先発薬としてはファイザーのバイアグラ(Viagra[1]) が商品名(商標)として、肺動脈性高血圧症の治療薬としてはレバチオ(Revatio[2])が商品名として用いられているほか、ファイザーの日本での特許切れにより、各社からの後発医薬品も存在する。

効能

血管拡張薬, 勃起不全治療薬, ホスホジエステラーゼV阻害薬

説明

Sildenafil was launched as Viagra in the US for the treatment of organic orland psychological male erectile dysfunction (ED). Sildenafil can be obtained by functional rearrangement of the corresponding 5-aryl 1,3-dialkyl pyrazolo[4,3- d]pyrimidin-7-one, itself synthesized in a seven-step sequence from a pyrazole- 5-carboxylate. Sildenafil is a potent and selective inhibitor of type V cGMP phosphodiesterases (PDE5) ; IC50 = 3nM on isozymes from human corpus cavernosum tissue. This orally-active therapy is completely new and presents advantages over the classically recommended options such as vacuum constriction devices, drug injection or prosthesis implantation ; for these reasons, this first drug is likely to have a large acceptance fot the treatment of male ED. In experiments with incubated rabbit penile tissue, Sildenafil was shown to cause accumulation of cGMP. By inhibiting the enzyme PDE5, the predominant isozyme in the corpus cavernosum, Sildenafil induces an elevation of levels of second messager cGMP, which is involved in the regulation of vascular tone ; it was suggested that the specific elevation of cGMP due to Sildefanil would mediate an enhancement of nitric oxide-dependent relaxation of corpus cavernosal tissue. Several clinical studies using 10-100 mg Sildenafil have confirmed a good effectiveness and tolerability in healthy males. New trials in women with sexual disfunction have been initiated and positive results could enlarge the potential market of this drug.

化学的特性

White Solid

Originator

Pfizer (UK)

使用

antiviral

使用

An orally active selective type 5 cGMP phosphodiesterase inhibitor.

定義

ChEBI: A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.

適応症

Sildenafil (Viagra) is a selective inhibitor of PD-5, an enzyme that inactivates cGMP. Vardenifil (Levitra) is a particularly effective inhibitor of PD-5. It has a shorter onset of action and can be used in smaller doses than sildenafil. Other drugs used in the treatment of ED exert their effects through other biochemical pathways, both central and peripheral.

適応症

Sildenafil (Viagra) was developed more than 10 years ago as an antihypertensive and antianginal drug. It proved ineffective in these applications but was shown to affect the smooth muscles of the penis.

brand name

Viagra (Pfizer);Segurex.

作用機序

Sildenafil is readily absorbed after oral administration and reaches peak plasma levels after about an hour. It undergoes hepatic metabolism and has a terminal half-life of about 4 hours.An initial dose of 50 mg is taken about an hour prior to sexual activity to induce penile erection.

臨床応用

Sildenafil is a selective inhibitor of cGMP-specific PD-5 and therefore inhibits the degradation of cGMP. PD-5, the predominant type in the corpus cavernosum, also is present in other tissues (e.g., lungs, platelets, and eye). The selective inhibition of this enzyme facilitates the release of nitric oxide and smooth muscle relaxation of the corpus cavernosa. Sildenafil enhances erection by augmenting nitric oxide–mediated relaxation pathways. It has been suggested that sildenafil’s mechanism of action is due to cross-talk between cGMP- and cAMPdependent transduction pathways within the cavernous muscles.

副作用

Orally administered sildenafil is an effective and well-tolerated treatment for men with ED, including those with diabetes mellitus. It has also been used for so-called salvage therapy in men who do not respond to intracorporeal injections of other agents. Headache is a common side effect, as are flushing and rhinitis.More serious side effects include definite or suspected myocardial infarctions and cardiac arrest.

シルデナフィル 上流と下流の製品情報

原材料

準備製品


シルデナフィル 生産企業

Global( 226)Suppliers
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139755-83-2(シルデナフィル)キーワード:


  • 139755-83-2
  • 99% high purity Sildenafil CAS No 139755-83-2
  • SILDENAFIL
  • 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7h-pyrazol[4,3d]pyrimidin-7-one
  • 7H-Pyrazolo[4,3-d]pyriMidin-7-one, 5-[2-ethoxy-5-[(4-Methyl -1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-
  • Sildenafil solution
  • 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one
  • 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
  • 5-[2-ethoxy-5-(4-Methylpiperazine-1-sulfonyl)phenyl]-1-Methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyriMidin-7-one
  • 1-[[3-(4,7-Dihydro-1-Methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-Methylpiperazine
  • 5-[2-Ethoxy-5-[(4-Methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-7H-pyrazolo[4,3-d]pyriMidin-7-one
  • Revatio
  • UK-92480
  • +8617197824028
  • sildenafil BPC
  • 5-(2-ETHOXY-5-(4-METHYLPIPERAZIN-1-YL-SU LFONYL)PHENYL)-1-METHYL-3-N-PROPYL-6-DIH YDRO-7H-PYRAZOL(4,3-D)PYRIMIDIN-7-ONE
  • Sildefil
  • SIDANAFIL
  • 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4.3-d]pyrimidin-7-one
  • 4-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,8,9-tetrazabicyclo[4.3.0]nona-3,7,10-trien-2-one
  • Sildenafil(Viagra)
  • 5-(2-ETHOXY-5-(4-METHYLPIPERAZIN-1-YLSULFONYL)PHENYL)-1-METHYL-3-PROPYL-1H-PYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE CITRATE
  • 5-[2-Ethoxy-5-(4-methylpiperazin-1-ylsul-fonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
  • viagTa
  • sildenafil Whatsapp
  • 139755-83-2 Sildenafil for sale Email: cindy@hbmeihua.cn
  • Sildenafile
  • Manufacturers wholesale 139755-83-2 sildenafil citrate powder CAS NO.139755-83-2
  • Effective Sildenafil Viagra Man Sex Enhancement Powder Sildenafil Citrate CAS 139755-83-2
  • Sildenafil CAS: 139755-83-2
  • シルデナフィル
  • シルデナフィル
  • シルデナフィル 溶液
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