ノルゲストレル
ノルゲストレル 物理性質
- 融点 :
- 239-241 °C(lit.)
- 沸点 :
- 392.36°C (rough estimate)
- 比重(密度) :
- 1.0697 (rough estimate)
- 屈折率 :
- 1.4900 (estimate)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- クロロホルム（微量、超音波処理）、ジクロロメタン（微量）、メタノール（微量）
- 酸解離定数(Pka):
- 13.09±0.40(Predicted)
- 色:
- ジエチルエーテル-ヘキサンからの結晶
- InChIKey:
- WWYNJERNGUHSAO-XUDSTZEESA-N
- CAS データベース:
- 6533-00-2(CAS DataBase Reference)
- EPAの化学物質情報:
- Norgestrel (6533-00-2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10006319 |
Norgestrel |
6533-00-2 |
100mg |
￥7000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY10006319 |
Norgestrel |
6533-00-2 |
500mg |
￥30000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
PHR2487 |
Pharmaceutical Secondary Standard; Certified Reference Material
Norgestrel Pharmaceutical Secondary Standard; Certified Reference Material |
6533-00-2 |
200MG |
￥39200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
N1250000 |
European Pharmacopoeia (EP) Reference Standard
Norgestrel European Pharmacopoeia (EP) Reference Standard |
6533-00-2 |
n1250000 |
￥25000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1472000 |
United States Pharmacopeia (USP) Reference Standard
Norgestrel United States Pharmacopeia (USP) Reference Standard |
6533-00-2 |
125mg |
￥45300 |
2024-03-01 |
購入 |
ノルゲストレル 化学特性,用途語,生産方法
効能
避妊薬, プロゲステロン受容体作動薬
説明
Norgestrel is a synthetic progestin and a racemic mixture of dextronorgestrel and levonorgestrel , of which levonorgestrel is the biologically active component.
In vivo, norgestrel administered
via intrauterine device (IUD) prevents pregnancy in rats. Formulations containing nogestrel have been used as contraceptives.
化学的特性
White Solid
使用
A metabolite of Norgestrel.
一般的な説明
Norgestrel, (17α)-(±)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, and levonorgestrel, (17α)-(-)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one,have a C13 ethyl group instead of the C13 methyl but haveprogestational properties similar to those of norethindrone,with decreased androgenic effects. The ethyl group apparentlyprovides unfavorable steric interactions with the ARthat reduce the affinity compared with that with the PRs.Norgestrel is a racemic mixture, while levonorgestrel is thesingle active levorotatory enantiomer. Norgestrel is usedonly in oral contraceptives. Levonorgestrel is used in bothoral combination birth control products and polymeric implantsthat provide contraception for up to 5 years.
安全性プロファイル
Human reproductive effects byingestion and implant: menstrual cycle changes ordisorders and female fertility index changes. Anexperimental teratogen. Experimental reproductiveeffects. Questionable carcinogen with experimentalneoplastigenic data. An o
ノルゲストレル 上流と下流の製品情報
原材料
準備製品
ノルゲストレル 生産企業
Global( 221)Suppliers
6533-00-2(ノルゲストレル)キーワード:
- 6533-00-2
- dl-13b-ethyl-17a-ethynyl-17b-hydroxygon-4-en-3-one
- 4-GONEN-13BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-OL-3-ONE
- 4-PREGNEN-13BETA-ETHYL-18,19-DINOR 17BETA-OL-3-ONE-20-YNE
- 4-ESTREN-17-ALPHA-ETHYNYL-18-HOMO-17-BETA-OL-3-ONE(+/-)
- D(-)-NORGESTREL
- D-NORGESTREL
- (+-)-13-ethyl-17-hydroxy-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
- 13-ethyl-17-hydroxy-19-dinorpregn-4-en-20-yn-3-on(17-alpha)-(+-)-1
- monovar
- sh70850
- sh850
- wy3707
- (17a)-(-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
- Neogest
- Ovrette
- (+-)-13-Ethyl-17a-ethynyl-17-hydroxygon-4-en-3-one
- (+-)-17a-Ethynyl-13b-ethylgon-4-en-17b-ol-3-one
- (+-)-17a-Ethynyl-13-ethyl-17-hydroxygon-4-en-3-one
- 13-Ethyl-17a-ethynyl-17b-hydroxy-4-gonen-3-one
- 13-beta-ethyl-17-beta-hydroxy-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
- Norgestrel (DL-)
- LEVONORGESTRAL
- Norgestrel Solution, 100ppm
- Norgestrel IP
- alpha-norgestrel
- dl-13-beta-ethyl-17-alpha-ethynyl-17-beta-hydroxygon-4-en-3-one
- dl-13-beta-ethyl-17-alpha-ethynyl-19-nortestosterone
- dl-norgestrel
- fh122-a
- ldnorgestrel
- rac-(13R*)-13-エチル-17α-ヒドロキシ-18,19-ジノルプレグナ-4-エン-20-イン-3-オン
- rac-(17R)-13α*-エチル-17-ヒドロキシ-18,19-ジノルプレグナ-4-エン-20-イン-3-オン
- ノルゲストレル
- ノルゲストレル (JP17)
- エストロゲン
- ステロイドホルモン
- 避妊薬
- 黄体ホルモン
- 経口避妊薬
- 抗腫瘍薬