ブチルエーテル 化学特性,用途語,生産方法
外観
無色澄明の液体
溶解性
水に難溶 (0.03～0.05g/100ml 水 20℃), 各種有機溶剤に可溶。エタノールに極めて溶けやすく、水にほとんど溶けない。
用途
有機合成反応用溶媒、抽出溶媒
用途
有機合成反応用溶剤、有機酸
説明
Butyl ether (dibutyl ether) is a colorless, stable liquid, with a mild ether-like odor. It is immiscible with water, with a specific gravity of 0.8, which is lighter than water. Butyl ether is a moderate fire risk and will form explosive peroxides on aging. Flammable range is 1.5%–7.6% in air, with a boiling point of 286°F (141°C) and a flash point of 77°F (25°C). Ignition temperature is 382°F (194°C), and the vapor density is 4.5, which is heavier than air. In addition to flammability, butyl ether is toxic on prolonged inhalation. The four-digit UN identification number is 1149. The NFPA 704 designation is health 2, flammability 3, and reactivity 1. The primary use is as a solvent.
化学的特性
Di-n-butyl ether is colourless liquid with ether-like odour
使用
Di-n-butyl ether is used as a solvent for Grignard, Witting and alkyl lithium reactions. It is also used as a solvent for oils and fats and some natural and synthetic resins. It is considered as a replacement for terathydofuran in organic synthesis due to its less water and peroxide and high boiling point. In the pharmaceutical industry, it is used in the manufacturing process of active pharmaceutical ingredient such as procarbazine and cefaclor. In addition to this, it is used as an important solvent for the application of the coating.
一般的な説明
Di-n-butyl ether is a clear colorless liquid with an ethereal odor. Flash point below 141°F. Less dense than water and insoluble in water. Vapors heavier than air. Irritates the eyes, nose, throat, and respiratory tract.
空気と水の反応
Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154, 164]. A mixture of liquid air and diethyl ether exploded spontaneously [MCA Case History 616 1960]. Insoluble in water.
反応プロフィール
Ethers, such as BUTYL ETHER can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
危険性
Toxic on prolonged inhalation. Flammable,
moderate fire risk. May form explosive peroxides,
especially in anhydrous form.
健康ハザード
Inhalation causes irritation of nose and throat. Liquid irritates eyes and may irritate skin on prolonged contact. Ingestion causes irritation of mouth and stomach.
火災危険
Behavior in Fire: Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back.
化学反応性
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
工業用途
n-Butyl ether is used in
synthesis reactions that require an anhydrous, inert solvent. This ether is a valuable
extraction solvent for aqueous solutions because of its low water solubility. n-Butyl
ether when mixed with ethanol or butanol is an excellent solvent for ethyl cellulose.
安全性プロファイル
Mildly toxic by
inhalation, ingestion, and skin contact.
Human systemic effects by inhalation:
conjunctiva irritation and unspecified nasal
effects. An experimental skin and human
eye irritant. See also ETHERS. Dangerous
fire hazard when exposed to heat, flame, oroxidizers. Incompatible with NCL and
oxidizing materials. To fight fire, use alcohol
foam, dry chemical. When heated to
decomposition it emits acrid smoke and
fumes.
職業ばく露
Di-n-butyl ether is used as a solvent for hydrocarbons, fatty materials; extracting agent in used metals separation; solvent purification, making other chemicals. Incompatibilities: May form explosive mixture with air. May accumulate static electrical charges, and may cause ignition of its vapors. Incompatible with strong acids; oxidizers. Contact with air or light may form unstable and explosive peroxides, especially anhydrous form.
環境運命予測
Butyl ether has the ability to dissolve lipids. As a result, it
causes irritation and pain on contact with the eyes and nasal
mucosa. It also causes dermal irritation and dermatitis on
contact with the skin. Damage caused by butyl ether appears
to be scattered loss of epithelial cells due to solution of
phospholipid cell membranes. At the central nervous system
(CNS) level, butyl ether, like other volatile organic solvents,
depresses the CNS by dissolving in the lipid membrane of the
cells and disrupting the lipid matrix. These effects are known
as membrane fluidization. At the molecular level, membrane
fluidization disrupts solute gradient homeostasis, which is
essential for cell function.
輸送方法
UN1149 Butyl ethers & Dibutyl ethers, Hazard
Class: 3; Labels: 3—Flammable liquid
純化方法
Peroxides (detected by the liberation of iodine from weakly acid HCl solutions of 2% KI) can be removed by shaking 1L of ether with 5-10mL of a solution comprising of 6.0g of ferrous sulfate and 6mL conc H2SO4 and 110mL of water, with aqueous Na2SO3, or with acidified NaI, water, then aqueous Na2S2O3. After washing with dilute NaOH, KOH, or Na2CO3, then water, the ether is dried with CaCl2 and distilled. It can be further dried by distillation from CaH2 or Na (after drying with P2O5), and stored in the dark with Na or NaH. The ether can also be purified by treating with CS2 and NaOH, expelling the excess sulfide by heating. The ether is then washed with water, dried with NaOH and distilled [Kusama & Koike J Chem Soc Jpn, Pure Chem Sect 72 229 1951]. Other purification procedures include passage through an activated alumina column to remove peroxides, or through a column of silica gel, and distillation after adding about 3% (v/v) of a 1M solution of MeMgI in n-butyl ether. [Beilstein 1 IV 1520.]
廃棄物の処理
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed.
ブチルエーテル 上流と下流の製品情報
原材料
準備製品