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マレイン酸

マレイン酸 化学構造式
110-16-7
CAS番号.
110-16-7
化学名:
マレイン酸
别名:
マレイン酸;cis-1,2-エチレンジカルボン酸;(Z)-2-ブテン二酸;水素マレアート;(2Z)-2-ブテン二酸;トキシル酸;(Z)-ブタ-2-エン二酸;cis-2-ブテン二酸;(2Z)-ブト-2-エン二酸;マレイン酸, 98+%;マレイン酸標準物質
英語化学名:
Maleic acid
英語别名:
NA 2215;Maleicaci;MALEIC ACID;malenicacid;TOXILIC ACID;maleinicacid;Malenic acid;MaleicAcidGr;MaleicAcidBp;Maleic acid 0
CBNumber:
CB2852803
化学式:
C4H4O4
分子量:
116.07
MOL File:
110-16-7.mol

マレイン酸 物理性質

融点 :
137-140 °C(lit.)
沸点 :
275°C
比重(密度) :
1.59 g/mL at 25 °C(lit.)
屈折率 :
1.5260 (estimate)
闪点 :
127 °C
貯蔵温度 :
Store at RT.
溶解性:
478.8g/l
酸解離定数(Pka):
1.83(at 25℃)
外見 :
Powder/Solid
色:
White
比重:
1.59
PH:
1.3 (100g/l, H2O, 20℃)
水溶解度 :
790 g/L (25 ºC)
Merck :
14,5703
BRN :
605762
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents, bases.
InChIKey:
VZCYOOQTPOCHFL-OWOJBTEDSA-N
CAS データベース:
110-16-7(CAS DataBase Reference)
NISTの化学物質情報:
2-Butenedioic acid (Z)-(110-16-7)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-36/37/38-43
Sフレーズ  26-28-37-28A-46-24
RIDADR  3261
WGK Germany  1
RTECS 番号 OM9625000
TSCA  Yes
国連危険物分類  8
容器等級  III
HSコード  29173990
有毒物質データの 110-16-7(Hazardous Substances Data)
化審法 (2)-1100
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

マレイン酸 価格 もっと(42)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA14596 マレイン酸, 98+%
Maleic acid, 98+%
110-16-7 250g ¥5850 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01AFAA14596 マレイン酸, 98+%
Maleic acid, 98+%
110-16-7 1000g ¥17250 2018-12-26 購入
東京化成工業 M0006 マレイン酸 >99.0%(T)
Maleic Acid >99.0%(T)
110-16-7 25g ¥1700 2018-12-04 購入
東京化成工業 M0006 マレイン酸 >99.0%(T)
Maleic Acid >99.0%(T)
110-16-7 500g ¥2900 2018-12-04 購入
関東化学株式会社(KANTO) 12523-3A マレイン酸
Maleic acid
110-16-7 5kg ¥25000 2018-12-13 購入

マレイン酸 化学特性,用途語,生産方法

外観

白色, 結晶性粉末又は塊

定義

本品は、次の化学式で表される不飽和有機酸である。

溶解性

水及びエタノールに溶けやすい。

用途

有機合成原料、酸の一次標準(アルカリ標準液の標定)。

用途

ポリエステル樹脂原料,医薬原料 、接着剤原料、フマール酸、アルキッド樹脂、合成潤滑油原料

化粧品の成分用途

pH調整剤、香料

説明

Maleic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Its chemical formula is HO2CCHCHCO2H. Maleic acid is the cis-isomer of butenedioic acid, where as fumaric acid is the trans-isomer. It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications.

化学的特性

Maleic acid occurs as a white crystalline (monoclinic) powder and possesses a faint acidulous odor and an astringent taste.
Fumaric acid and maleic acid are the simplest unsaturated carboxylic diacids. These acids experience two-step dissociation in aqueous solutions.They have the same structural formula but different spatial configurations. Fumaric acid is the trans and maleic acid the cis isomer. The physical properties of maleic acid and fumaric acid are very different. The cis isomer is less stable. Maleic acid is used in the preparation of fumaric acid by catalytic isomerization.

化学的特性

Maleic acid, HOOCCH:CHCOOH, also known as maleinic acid and toxilic acid,is a colorless crystalline dibasic acid. It is soluble in water and alcohol. Maleic acid is used in manufacturing synthetic resins, in textile processing, and in preserving oils and fats.

化学的特性

Maleic acid is a white crystalline solid. Faint, acid like odor.

物理的性質

Maleic acid is a less stable molecule than fumaric acid. The difference in heat of combustion is 22.7 kJ·mol?1. The heat of combustion is -1355 kJ / mole. Maleic acid is more soluble in water than fumaric acid. The melting point of maleic acid (135 °C) is also much lower than that of fumaric acid (287 °C). Both properties of maleic acid can be explained on account of the intramolecular hydrogen bonding that takes place in maleic acid at the expense of intermolecular interactions, and that are not possible in fumaric acid for geometric reasons.

使用

Maleic acid is an industrial raw material for the production of glyoxylic acid by ozonolysis.
Maleic acid may be used to form acid addition salts with drugs to make them more stable, such as indacaterol maleate.

使用

manufacture of artificial resins; to retard rancidity of fats and oils in 1:10,000 (these are said to keep 3 times longer than those without the acid); dyeing and finishing wool, cotton, and silk; preparing the maleate salts of antihistamines and similar drugs.

定義

ChEBI: A butenedioic acid in which the double bond has cis- (Z)-configuration.

調製方法

Maleic anhydride is the main source of maleic acid produced by hydration. Maleic anhydride is prepared commercially by the oxidation of benzene or by the reaction of butane with oxygen in the presence of a vanadium catalyst.

反応性

Although not practised commercially, maleic acid can be converted into maleic anhydride by dehydration, to malic acid by hydration, and to succinic acid by hydrogenation (ethanol / palladium on carbon). It reacts with thionyl chloride or phosphorus pentachloride to give the maleic acid chloride (it is not possible to isolate the mono acid chloride). Maleic acid, being electrophilic, participates as a dienophile in many Diels - Alder reactions.

一般的な説明

Maleic acid is a colorless crystalline solid having a faint odor. Maleic acid is combustible though Maleic acid may take some effort to ignite. Maleic acid is soluble in water. Maleic acid is used to make other chemicals and for dyeing and finishing naturally occurring fibers.

空気と水の反応

Soluble in water.

反応プロフィール

Maleic acid is a colorless to white crystalline solid. Moderately toxic. When heated to decomposition Maleic acid emits irritating fumes and acrid smoke [Lewis, 3rd ed., 1993, p. 790].

危険性

Toxic by ingestion.

健康ハザード

Inhalation causes irritation of nose and throat. Contact with eyes or skin causes irritation.

火災危険

Special Hazards of Combustion Products: Irritating smoke containing maleic anhydride may form in fire.

応用例(製薬)

Maleic acid is used in the pharmaceutical industry as a pH modifier and a buffering agent.It is also used to prevent rancidity of oils and fats; a ratio of 1 : 10 000 is usually sufficient to retard rancidity. Maleic acid is commonly used as a pharmaceutical intermediate to form the maleate salts of several categories of therapeutic agents, such as salts of antihistamines and other drug substances.

安全性プロファイル

Moderately toxic by ingestion and skin contact. Passes through intact skin. A skin and severe eye irritant and a corrosive. Believed to be more toxic than its isomer, fumeric acid. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.

安全性

Maleic acid is generally regarded as a nontoxic and nonirritant material when used at low levels as an excipient. Maleic acid is used in oral, topical, and parenteral pharmaceutical formulations in addition to food products.
LD50 (mouse, oral): 2.40g/kg(7)
LD50 (rabbit, skin): 1.56g/kg
LD50 (rat, oral): 0.708g/kg

職業ばく露

Maleic acid is used to make artificial resins, antihistamines, and to preserve (retard rancidity) of fats and oils

応急処置

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 30 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water or milk. Do not induce vomiting. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

貯蔵

Maleic acid converts into the much higher-melting fumaric acid (mp: 287°C) when heated to a temperature slightly above its melting point.
Maleic acid is combustible when exposed to heat or flame. The bulk material should be stored in airtight glass containers and protected from light. It is recommended not to store it above 25°C.

輸送方法

UN2215 Maleic acid, Hazard class: 8; Labels: 8-Corrosive material.

純化方法

Crystallise the acid from acetone/pet ether (b 60-80o) or hot water. Dry it at 100o. [Beilstein 2 H 748, 2 I 303, 2 II 641, 2 III 1911, 2 IV 2199.]

不和合性

Dust may form explosive mixture with air, Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, amines, reducing agents; alkali metals

不和合性

Maleic acid can react with oxidizing materials. Aqueous solutions are corrosive to carbon steels.

廃棄物の処理

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Liquid: incinerate after mixing with a flammable solvent. Use afterburner for complete combustion. Solid: dissolve in a flammable solvent or package in paper and burn. See above

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (IM and IV injections; oral tablets and capsules; topical applications). Included in nonparenteral and parenteral medicines licensed in the UK.

マレイン酸 上流と下流の製品情報

原材料

準備製品


マレイン酸 生産企業

Global( 357)Suppliers
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Capot Chemical Co.,Ltd.
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+86-021-57951555
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Mainchem Co., Ltd.
+86-0592-6210733
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110-16-7(マレイン酸)キーワード:


  • 110-16-7
  • (Z)-but-2-enedioic acid
  • Maleic acid, extra pure, Ph Eur, BP
  • Maleic Acid (300 mg)
  • MALEIC ACID, WHITE
  • (2Z)-But-2-ene-1,4-dioic acid
  • Maleic acid, 99% 100GR
  • Maleic acid, 99% 1KG
  • Maleicaci
  • Maleic acid 0
  • Maleic acid ReagentPlus(R), >=99.0% (HPLC)
  • Maleic acid Vetec(TM) reagent grade, 98%
  • (2Z)-But-2-enedioic acid
  • DL-Maleic acid
  • AKOS BBS-00003804
  • (z)-2-butenedioicaci
  • (z)-2-butenedioicacid
  • (z)-butenedioicaci
  • 1,2-Ethylenedicarboxylic acid, (Z)
  • ACIDUM MALEICUM
  • BUFFER, MALEIC ACID, PH 2.35
  • CIS-1,2-ETHYLENEDICARBOXYLIC ACID
  • CIS-2-BUTENEDIOIC ACID
  • CIS-BUTENEDIODIC ACID
  • CIS-BUTENEDIOIC ACID
  • MALEIC ACID
  • Z-BUTENEDIOIC ACID
  • TOXILIC ACID
  • (2Z)-2-Butenedioic acid
  • (z)-1,2-ethylenedicarboxylicacid
  • (Z)-2-Butenedioic acid
  • マレイン酸
  • cis-1,2-エチレンジカルボン酸
  • (Z)-2-ブテン二酸
  • 水素マレアート
  • (2Z)-2-ブテン二酸
  • トキシル酸
  • (Z)-ブタ-2-エン二酸
  • cis-2-ブテン二酸
  • (2Z)-ブト-2-エン二酸
  • マレイン酸, 98+%
  • マレイン酸標準物質
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