レミフェンタニル塩酸塩

レミフェンタニル塩酸塩 化学特性,用途語,生産方法

効能

鎮痛薬, オピオイド受容体作動薬

商品名

アルチバ (ヤンセンファーマ)

説明

Ultiva was launched in Germany and the US for use in general anesthesia and immediate post-operative pain management. This compound can be prepared via the Michael addition of a 4,4-disubstituted piperidine to methyl acrylate. It behaves as a specific μ-opiod agonist that is about 30 times more potent than its chemical relative alfentanil. While its pharmacodynamic properties are similar to other μ agonists, remifentanil has unique pharmacokinetic properties. It has a rapid onset (1.6 min) and a rapid offset (5.4 min) independent of duration of administration. This has been attributed to its rapid catabolism by general esterases to the corresponding acrylic acid derivative. The metabolite has 0.01 to 0.0005 times the activity of remifentanil and is excreted via the kidneys (80% recovery).

化学的特性

White Solid

使用

Labelled synthetic mu-opioid agonist. This is a controlled substance (opiate)

薬物動態学

Remifentanil is much like alfentanil in its pharmacodynamic effects. It is a selective μ opioid agonist with 15 to 20 times greater potency than alfentanil. Remifentanil has an onset of action of 1 to 3 minutes when given intravenously. Its unique property is its rapid offset of action, which is independent of the duration of administration of the compound. Thus, it is very useful for titration of antinociceptive effect, followed by a rapid and predictable recovery time of 3 to 5 minutes. The short duration of action is a result of the ester group, which has been rationally designed into the substituent on the piperidine nitrogen. This ester group is rapidly hydrolyzed to the inactive carboxylic acid by serum and tissue esterases, making the drug's duration of action essentially independent of the liver or renal function of the patient. Remifentanil is used extensively for analgesia associated with general anesthesia procedures. It often is used in combination with injectable general anesthetic agents, such as midazolam or propofol.

レミフェンタニル塩酸塩 上流と下流の製品情報

原材料

準備製品

132539-07-2(レミフェンタニル塩酸塩)キーワード:

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• 132539-07-2
• Remifentanil Hydrochloride
• 4-(Methoxycarbonyl)-4-[(1-oxopropyl)phenylamino]-1-piperidinepropanoic Acid Methyl Ester Hydrochloride
• GI 87084
• Remifentanyl Hydrochloride
• Ultiva
• GI 87084B
• 1-Piperidinepropanoic acid, 4-(methoxycarbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester, monohydrochloride
• Remifentanil HCl
• Unii-5V444H5wic
• WFBMIPUMYUHANP-UHFFFAOYSA-N
• REMIFENTANIL HYDROCHLORIDE SOLUTION
• remifnetanil hydrochloride
• Remifentanil (hydrochloride) (CRM)
• Remifentanil HydrochlorideQ: What is Remifentanil Hydrochloride Q: What is the CAS Number of Remifentanil Hydrochloride Q: What is the storage condition of Remifentanil Hydrochloride Q: What are the applications of Remifentanil Hydrochloride
• 33,72-difluoro-N,N′-dimethyl-5-oxo-2,8-dioxa-4,6-diaza-1(4),9(4)-dipyridina-3(1,4),7(1,4)-dibenzenanonaphane-12,92-dicarboxamide
• レミフェンタニル塩酸塩
• レミフェンタニル塩酸塩 (JAN)
• 塩酸レミフェンタニル