GW501516

GW501516 化学構造式
317318-70-0
CAS番号.
317318-70-0
化学名:
GW501516
别名:
GW501516
英語名:
GW-501516
英語别名:
CARDARINE;GW 1516;2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid;ENDUROBOL;CS-788;GSK-516;CARDAROL;GW-501615;Cardrarine;SARMS GW501516
CBNumber:
CB31476045
化学式:
C21H18F3NO3S2
分子量:
453.5
MOL File:
317318-70-0.mol
MSDS File:
SDS

GW501516 物理性質

融点 :
134-136°C
沸点 :
584.5±60.0 °C(Predicted)
比重(密度) :
1.42±0.1 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMSO:可溶20mg/mL、透明
外見 :
酸解離定数(Pka):
3.17±0.10(Predicted)
色:
白からベージュ
BRN :
18515150
安定性::
光に敏感
InChI:
InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChIKey:
YDBLKRPLXZNVNB-UHFFFAOYSA-N
SMILES:
C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C=C3)=NC=2C)C=C1C
CAS データベース:
317318-70-0
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
WGK Germany  3
RTECS 番号 AI9105500
絵表示(GHS) GHS hazard pictograms
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告 GHS hazard pictograms
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P271 屋外または換気の良い場所でのみ使用すること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P302+P352 皮膚に付着した場合:多量の水と石鹸で洗うこと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P312 気分が悪い時は医師に連絡すること。
P321 特別な処置が必要である(このラベルの... を見よ)。
P332+P313 皮膚刺激が生じた場合:医師の診断/手当てを受けるこ と。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

GW501516 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCG931500 GW501516
GW 501516
317318-70-0 25mg ¥72600 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC5674
GW 501516
317318-70-0 10mg ¥72000 2024-03-01 購入
Sigma-Aldrich Japan SML1491 ≥98% (HPLC)
GW501516 ≥98% (HPLC)
317318-70-0 5mg ¥22400 2024-03-01 購入
Sigma-Aldrich Japan 43732 analytical standard
{2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid analytical standard
317318-70-0 25mg ¥38500 2023-06-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCG931500 GW501516
GW 501516
317318-70-0 5mg ¥31500 2024-03-01 購入

GW501516 化学特性,用途語,生産方法

説明

GW501516, also known as GW-1516 or cardarine and endurobol, is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist. Activation of the receptor will increase fat-burning capacity and muscle production, as it changes the body's fuel preference from glucose to lipids.

化学的特性

White Solid

来歴

GW501516, also known as Cardarine, was originally discovered in the early 1990s during a research collaboration between two large pharmaceutical companies. The initial proposed use was for the treatment of hyperlipidemia (elevated fats in the blood), though later studies looked at its effectiveness for treating obesity, diabetes, and cardiovascular disease.

使用

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. Exhibits selectivity for PPARd compared t

定義

ChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.

一般的な説明

GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. It can regulate expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells and has been shown to block insulin resistance and fatty acid-induced nuclear factor-κB (NF-κB) activation.

生物活性

GW 501516 is a potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.

作用機序

GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1,000 fold selectivity over PPARα and PPARγ.In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure.[31] Furthermore, in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL).

GW501516 上流と下流の製品情報

原材料

準備製品


GW501516 生産企業

Global( 280)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com China 2530 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
+8618068519287
sales@xuanmingchem.com China 818 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10523 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210
sales@cellwh.com China 376 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 941 58
CONTIDE BIOTECH CO.,LTD
+852-53358525
xena@xljxcl.com China 305 58
Wuhan Boyuan Import & Export Co., LTD
+86-15175982296 15175982296;
Mike@whby-chem.com China 981 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5988 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039
admin@firsky-cn.com China 436 58
qingdao future trading Co., Ltd
+86-13335044410 +86-13335044410
cui56813@163.com China 110 58

GW501516  スペクトルデータ(1HNMR)


317318-70-0(GW501516)キーワード:


  • 317318-70-0
  • 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
  • GW 501516, >=98%
  • ENDUROBOL (GW-501516)/CARDARINE/
  • Cardarine(GW501516, GSK-516)
  • GW-501615
  • 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
  • {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid
  • Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI)
  • GW 1516 ,GSK-516
  • {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid
  • GW501516(GSK-516)
  • 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID
  • Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid
  • 2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid
  • 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid
  • GW501516, Free Acid
  • GSK-516
  • GW501516/GW1516/GW-1516/GW501516
  • 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic
  • GW-501516;GW 501516;GSK516;GSK 516
  • GW501516 (Cardarine)
  • GW501516(GSK-516; GW1516)
  • GW501516 White powder 99%
  • GW501516 Mass Lean Fat Burning Steroids Sarms Bodybuilding Supplements White Powder
  • Hot sale GW-501516 CAS NO.317318-70-0 CAS NO.317318-70-0
  • CS-788
  • (2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid
  • GW501516(CARDARINE) ENDUROBOL
  • GW501516 whnohe_lucy(at)163.com
  • Endurobol,Cardarine
  • GW501516
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