アルテスナート

アルテスナート 価格 もっと(10)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01LKTA6982	アルテスネート Artesunate	88495-63-0	50mg	￥11800	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTA6982	アルテスネート Artesunate	88495-63-0	100mg	￥17800	2024-03-01	購入
東京化成工業	A2191	アルテスナート >98.0%(HPLC)(T) Artesunate >98.0%(HPLC)(T)	88495-63-0	5g	￥4300	2024-03-01	購入
東京化成工業	A2191	アルテスナート >98.0%(HPLC)(T) Artesunate >98.0%(HPLC)(T)	88495-63-0	25g	￥13500	2024-03-01	購入
Sigma-Aldrich Japan	A3731	アルテスネイト from Artemisia annua Artesunate from Artemisia annua	88495-63-0	100mg	￥43500	2024-03-01	購入

アルテスナート 化学特性,用途語,生産方法

外観

白色～ほとんど白色粉末～結晶

効能

抗マラリア薬

化学的特性

Artesunate is an odorless bitter-tasting crystalline powder. soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of artesunate in these solvents is approximately 20, 14, and 11 mg/ml, respectively. Artesunate is sparingly soluble in aqueous buffers.

使用

Artesunate, a semi-synthetic artemisinin derivative, has been shown to be effective against parasites, such as liver flukes, and has also shown cytotoxic effects on different types of tumor cell lines. artesunate belong to Antimalarial which is clinically useful for treatment of malaria and other parasitic diseases.

定義

ChEBI: Artesunate is an artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria. It has a role as an antimalarial, a ferroptosis inducer and an antineoplastic agent. It is an artemisinin derivative, a sesquiterpenoid, a dicarboxylic acid monoester, a cyclic acetal, a semisynthetic derivative and a hemisuccinate.

製造方法

Artemisinin was discovered in the 1970s as a result of an extensive screening of Chinese herbal extracts in the search of new antimalarial agents. Currently, the primary method for the production of artemisinin is the isolation from dried leaves of the plant Artemisia annua. Furthermore, the global supply of this life-saving drug exclusively from natural sources remains highly limited. As a result, a novel approaches for large-scale production of artemisinin have been developed. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in a basic medium.

A simplified and scalable synthesis of artesunate

一般的な説明

Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.

Mode of action

Artesunate is a water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. It acts on the electron transport chain to generate local reactive oxygen species and cause depolarization of the mitochondrial membrane. It inhibits TNF-induced proinflammatory cytokine production by inhibiting NF-κB and PI3 kinase/Akt signaling pathways in human rheumatoid arthritis fibroblast-like synoviocytes. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua.

アルテスナート 上流と下流の製品情報

原材料

準備製品

アルテスナート 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	816	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 18829239519	sales06@tgybio.com	China	961	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

88495-63-0(アルテスナート)キーワード:

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• 88495-63-0
• Artesunate (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
• ARTESUNATE
• ArtesunateC19H28O8
• Butanedioic Acid Mono(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] Ester
• Arteannuinum
• Arteannuinum succinate
• vARTESUNATE
• (3R,5aα,8aα,12aR)-Decahydro-10α-(3-carboxypropionyloxy)-3,6α,9β-trimethyl-3β,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin
• Succinic acid 1-[(3R,12aR)-3,6α,9β-trimethyl-3β,12α-epoxy-3,4,5,5aα,6,7,8,8aα,9,10-decahydropyrano[4,3-j]-1,2-benzodioxepin-10α-yl] ester
• Artesunate (200 mg)
• AsuMax
• Cosunate
• Gsunate Forte
• PlasMotriM
• PlasMotrin
• Qinghaozhi
• Saphnate
• ARTESUTE
• 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
• (91487-94-4) artesunate
• Artesunate 88495-63-0
• Artesunate >
• Artesunate Artesunate
• Artesunate USP/EP/BP
• Artesunate 13CD4
• ArtesunateQ: What is Artesunate Q: What is the CAS Number of Artesunate Q: What is the storage condition of Artesunate Q: What are the applications of Artesunate
• Artesunate (1042850)
• ARTENSUNATE
• Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester
• Artemisinin monosuccinate
• (3R,5aα,8aα,12aR)-デカヒドロ-10α-(3-カルボキシプロピオニルオキシ)-3,6α,9β-トリメチル-3β,12α-エポキシピラノ[4,3-j]-1,2-ベンゾジオキセピン
• プラスモトリム
• α-アルテスナート
• アーテスネート
• こはく酸1-[(3R,12aR)-3,6α,9β-トリメチル-3β,12α-エポキシ-3,4,5,5aα,6,7,8,8aα,9,10-デカヒドロピラノ[4,3-j]-1,2-ベンゾジオキセピン-10α-イル]
• アルテスニン酸
• アルテスン酸
• アルテスナート
• アルテスネート
• 4-オキソ-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-トリメチル-11,14,15,16-テトラオキサテトラシクロ[10.3.1.04,13.08,13]ヘキサデカン-10-イル]オキシ}ブタン酸
• こはく酸1-[(3aβ,6aβ,10aα)-9β,10bβ-ペルオキシ-3α,6β,9-トリメチルドデカヒドロピラノ[4,3,2-jk][2]ベンゾオキセピン-2β-イル]