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ヒドロキシプロピルメチルセルロース

ヒドロキシプロピルメチルセルロース 化学構造式
9004-65-3
CAS番号.
9004-65-3
化学名:
ヒドロキシプロピルメチルセルロース
别名:
ヒドロキシプロピルメチルセルロス;ヒドロキシプロピルメチルセルロース;ヒプロメロース (ヒドロキシプロピルメチルセルロース);ヒプロメロース;(ヒドロキシプロピル)メチルセルロース
英語化学名:
Hydroxypropyl methyl cellulose
英語别名:
MHPC;HPMC;hpmcd;goniosol;HPMC/MHPC;methocelhg;HPMC /HEMC;isoptotears;isoptoplain;HYPROMELLOSE
CBNumber:
CB3225318
化学式:
C3H7O *
分子量:
59.08708
MOL File:
9004-65-3.mol

ヒドロキシプロピルメチルセルロース 物理性質

比重(密度) :
1.39
溶解性:
H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
外見 :
powder
色:
White to cream
水溶解度 :
SOLUBLE
Merck :
14,4842
安定性::
Stable. Solid is combustible, incompatible with strong oxidizing agents.
EPAの化学物質情報:
Cellulose, 2-hydroxypropyl methyl ether(9004-65-3)

安全性情報

Sフレーズ  24/25
WGK Germany  1
RTECS 番号 NF9125000
3-10
TSCA  Yes
HSコード  39129000
化審法 一般化学物質

ヒドロキシプロピルメチルセルロース 価格 もっと(29)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ALF044779 ヒドロキシプロピルメチルセルロース
Hydroxypropyl methylcellulose
9004-65-3 50g ¥10200 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ALF044779 ヒドロキシプロピルメチルセルロース
Hydroxypropyl methylcellulose
9004-65-3 250g ¥28100 2018-12-26 購入
Sigma-Aldrich Japan 09963 (ヒドロキシプロピル)メチルセルロース
(Hydroxypropyl)methyl cellulose
9004-65-3 25g ¥10200 2018-12-25 購入
Sigma-Aldrich Japan 09963 (ヒドロキシプロピル)メチルセルロース
(Hydroxypropyl)methyl cellulose
9004-65-3 100g ¥25200 2018-12-25 購入
富士フイルム和光純薬株式会社(wako) W01TRCH998600 ヒプロメロース
Hypromellose
9004-65-3 100g ¥43800 2018-12-26 購入

ヒドロキシプロピルメチルセルロース MSDS


Hydroxypropyl methyl cellulose

ヒドロキシプロピルメチルセルロース 化学特性,用途語,生産方法

定義

本品は、メチルセルロース(*)のプロピレングリコールエーテルである。参照表示名称:メチルセルロース

化粧品の成分用途

結合剤、皮膜形成剤、親水性増粘剤、乳化安定剤、粘着剤

説明

Cellulose is a natural substance normally present in most diets because it is the major structural carbohydrate of green plants. Cellulose is essentially a linear polymer of glucopyranose units connected by (3-1,4-glucoside links. In nature, cellulose is present in plant cell walls as fibers. The molecular weight of isolated cellulose is approximately 50,000. The principal sources of cellulose for food related purposes are cotton linters and wood pulp. Chemical processing converts cellulose into forms or derivatives suitable for incorporation into food products, or for use in food packaging materials. Hydroxypropylmethyl cellulose is synthesized from methyl cellulose by the action of alkali and propylene oxide. The resultant product is a water soluble ether derivative of cellulose containing both methoxy and hydroxypropyl groups. The degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent. It is used as a thickening agent, stabilizer, and emulsifier.

化学的特性

Hypromellose is an odorless and tasteless, white or creamy-white fibrous or granular powder.

化学的特性

white or slightly beige powder or a viscous solution

使用

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

使用

A thickener for aqueous and non-aqueous systems.

使用

As emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods. Pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems. In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.

使用

Hydroxypropyl Methylcellulose is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose. it will gel as the temperature is increased in heating and upon cooling will liquefy. the gel temperature ranges from 60°c to 90°c, forming semifirm to mushy gels. it is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity. usage level ranges from 0.05 to 1.0%.

調製方法

A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with sodium hydroxide solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose. The alkali cellulose is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose. The fibrous reaction product is then purified and ground to a fine, uniform powder or granules. Hypromellose can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.

応用例(製薬)

Hypromellose is widely used in oral, ophthalmic, nasal, and topical pharmaceutical formulations.
In oral products, hypromellose is primarily used as a tablet binder, in film-coating,and as a matrix for use in extendedrelease tablet formulations. Concentrations between 2% and 5% w/w may be used as a binder in either wet- or dry-granulation processes. High-viscosity grades may be used to retard the release of drugs from a matrix at levels of 10–80% w/w in tablets and capsules. Hypromellose is also used in liquid oral dosage forms as a suspending and/or thickening agent at concentrations ranging from 0.25–5.0%.
Depending upon the viscosity grade, concentrations of 2–20% w/w are used for film-forming solutions to film-coat tablets. Lowerviscosity grades are used in aqueous film-coating solutions, while higher-viscosity grades are used with organic solvents. Examples of film-coating materials that are commercially available include AnyCoat C, Spectracel, Pharmacoat, and the Methocel E Premium LV series. Hypromellose is also used as a suspending and thickening agent in topical formulations. Compared with methylcellulose, hypromellose produces aqueous solutions of greater clarity, with fewer undissolved fibers present, and is therefore preferred in formulations for ophthalmic use. Hypromellose at concentrations between 0.45–1.0% w/w may be added as a thickening agent to vehicles for eye drops and artificial tear solutions. It is also used commercially in liquid nasal formulations at a concentration of 0.1%. Hypromellose is used as an emulsifier, suspending agent, and stabilizing agent in topical gels and ointments. As a protective colloid, it can prevent droplets and particles from coalescing or agglomerating, thus inhibiting the formation of sediments. In addition, hypromellose is used in the manufacture of capsules, as an adhesive in plastic bandages, and as a wetting agent for hard contact lenses. It is also widely used in cosmetics and food products.

安全性

Hypromellose is widely used as an excipient in oral, opthalmic, nasal, and topical pharmaceutical formulations. It is also used extensively in cosmetics and food products.
Hypromellose is generally regarded as a nontoxic and nonirritating material, although excessive oral consumption may have a laxative effect. The WHO has not specified an acceptable daily intake for hypromellose since the levels consumed were not considered to represent a hazard to health. In fact, high dosages of hypromellose are being investigated for treating various metabolic syndromes.
LD50 (mouse, IP): 5 g/kg(20) LD50 (rat, IP): 5.2 g/kg

貯蔵

Hypromellose powder is a stable material, although it is hygroscopic after drying.
Solutions are stable at pH 3–11. Hypromellose undergoes a reversible sol–gel transformation upon heating and cooling, respectively. The gelation temperature is 50–90°C, depending upon the grade and concentration of material. For temperatures below the gelation temperature, viscosity of the solution decreases as temperature is increased. Beyond the gelation temperature, viscosity increases as temperature is increased.
Aqueous solutions are comparatively enzyme-resistant, providing good viscosity stability during long-term storage. However, aqueous solutions are liable to microbial spoilage and should be preserved with an antimicrobial preservative: when hypromellose is used as a viscosity-increasing agent in ophthalmic solutions, benzalkonium chloride is commonly used as the preservative. Aqueous solutions may also be sterilized by autoclaving; the coagulated polymer must be redispersed on cooling by shaking.
Hypromellose powder should be stored in a well-closed container, in a cool, dry place.

不和合性

Hypromellose is incompatible with some oxidizing agents. Since it is nonionic, hypromellose will not complex with metallic salts or ionic organics to form insoluble precipitates.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic and nasal preparations; oral capsules, suspensions, syrups, and tablets;topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ヒドロキシプロピルメチルセルロース 上流と下流の製品情報

原材料

準備製品


ヒドロキシプロピルメチルセルロース 生産企業

Global( 286)Suppliers
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Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
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Shenzhen Sendi Biotechnology Co.Ltd.
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0086-571-86990109; 0086-18605816692
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Mainchem Co., Ltd.
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17052563120
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9004-65-3(ヒドロキシプロピルメチルセルロース)キーワード:


  • 9004-65-3
  • hpmcd
  • hydroxylpropylmethylcellulose
  • Hydroxymethylpropylcellulose
  • isoptoalkaline
  • isoptoplain
  • isoptotears
  • methocele,f,k
  • HydroxypropylMethylCellulose(Hpmc)
  • HydroxyPropylMethylCelluloseHpmcE15Lv
  • HydroxyPropylMethylCelluloseHpmcE5LvPremium
  • Hydroxypropyl Methyl Cellulose (Mpmc), Cas
  • Methylcellulose, propylene glycol ether
  • Hydroxypropyl methyl cellulose, M.N. 86,000
  • viscosity 4,000 cP (2% solution)
  • HYDROXYPROPYLMETHYLCELLULOSE,100CPS,FCC
  • HYDROXYPROPYLMETHYLCELLULOSE,4,000CPS,FCC
  • HYDROXYPROPYLMETHYLCELLULOSE,50CPS,FCC
  • HYPROMELLOSE,2208,100,000CPS,USP
  • HYPROMELLOSE,2208,100CPS,USP
  • HYPROMELLOSE,2208,4,000CPS,USP
  • HYPROMELLOSE,2910,50CPS,USP
  • Hydroxyproxyl Cellulose
  • METHYLHYDROXYPROPYLCELLULOSE
  • PROPYLENEGLYCOLMETHYLCELLULOSE
  • HYDROXPROPYLMETHYLCELLULOSE
  • HYDROXYPROPYLMETHYLCELLULOSEGEL
  • High-Substituted Hydroxyproxyl Cellulose
  • MHPC
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (13.0-18.0 M
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (3.0-7.0 MPA
  • ヒドロキシプロピルメチルセルロス
  • ヒドロキシプロピルメチルセルロース
  • ヒプロメロース (ヒドロキシプロピルメチルセルロース)
  • ヒプロメロース
  • (ヒドロキシプロピル)メチルセルロース
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