ChemicalBook
Chinese english Germany Korea

レゴラフェニブ

レゴラフェニブ 化学構造式
755037-03-7
CAS番号.
755037-03-7
化学名:
レゴラフェニブ
别名:
レゴラフェニブ
英語化学名:
Regorafenib
英語别名:
CS-169;CS-1930;Regafenib;regorafinib;BAY 73-4506;Regorafenib;Re orafenib;842-2937WAYNE;Reggae sorafenib;Fluoro-Sorafenib
CBNumber:
CB32498792
化学式:
C21H15ClF4N4O3
分子量:
482.82
MOL File:
755037-03-7.mol

レゴラフェニブ 物理性質

融点 :
206.0 to 210.0 °C
沸点 :
513.4±50.0 °C(Predicted)
比重(密度) :
1.491±0.06 g/cm3(Predicted)
酸解離定数(Pka):
12.04±0.70(Predicted)
外見 :
White powder.
CAS データベース:
755037-03-7

安全性情報

HSコード  29242990

レゴラフェニブ 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 R0142 レゴラフェニブ >98.0%(HPLC)
Regorafenib >98.0%(HPLC)
755037-03-7 25mg ¥12600 2021-03-23 購入
東京化成工業 R0142 レゴラフェニブ >98.0%(HPLC)
Regorafenib >98.0%(HPLC)
755037-03-7 100mg ¥37400 2021-03-23 購入

レゴラフェニブ 化学特性,用途語,生産方法

外観

白色~うすい黄色~うすい黄赤色粉末~結晶

効能

抗悪性腫瘍薬, 受容体チロシンキナーゼ阻害薬

説明

In September 2012, theUSFDAapproved regorafenib for the treatment of patients with metastatic colorectal cancer (CRC), especially those for whom standard therapies have failed, including fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, ananti-EGFRtherapy. Regorafenib is a multikinase inhibitor with potent inhibitory activity versus VEGFRs and PDFRs. Both of these classes of receptors are expressed on tumor cells and affect proliferation and angiogenesis. Regorafenib inhibited growth in murine xenograft models for colon, breast, renal, lung, melanoma, pancreatic, and ovarian tumors when dosed at 10–30 mg/kg. Regorafenib is a fluorinated analog of sorafenib, a multikinase inhibitor co-marketed by Bayer and Onyx for the treatment of kidney and liver cancer. The synthesis of regorafenib is accomplished in two steps from commercially available starting materials. 4-Aminophenol is coupled to 4-chloro-N-methyl- 2-pyridinecarboxamide to give 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline. Subsequent treatment with 4-chloro-3-(trifluoromethyl)phenyl isocycanate affords the urea, regorafenib.

説明

Regorafenib is an orally bioavailable multi-kinase inhibitor with anticancer activity. It inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ with IC50 values of 1.5, 2.5, 4.2, 7, 13, and 22 nM, respectively. Regorafenib also inhibits B-RAF, VEGFR3, FGFR, and Tie2 (IC50s = 28, 46, 202, and 311 nM, respectivey) as well as other kinases. In vivo, regorafenib (10 mg/kg) reduces tumor size in the MDA-MB-231 breast and 786-O renal cancer mouse xenograft models. It also reduces tumor microvessel area and inhibits tumor growth in a panel of mouse xenograft models. Formulations containing regorafenib have been used in the treatment of advanced gastrointestinal stromal tumors and metastatic colorectal cancer.

Originator

Bayer (Germany)

使用

It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.

使用

BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

使用

Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively

定義

ChEBI: A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previ usly received chemotherapy, anti-EGFR or anti-VEGF therapy.

brand name

Stivarga

レゴラフェニブ 上流と下流の製品情報

原材料

準備製品


レゴラフェニブ 生産企業

Global( 378)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Jurong Coupling Biotechnology Co., Ltd.
13656108824
coupling278191416@hotmail.com CHINA 184 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58

755037-03-7(レゴラフェニブ)キーワード:


  • 755037-03-7
  • Regorafenib
  • BAY 73-4506
  • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • BAY 73-4506(Regorafenib)
  • 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-N-MethylpicolinaMide
  • 4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide
  • REGORAFENIB BAY 73-4506 BAYER HEALTHCARE (SEE ALSO COLORECTAL, LUNG, STOMACH) PHASE II(REGORAFENIB) PHARMACEUTICALS (888) 842-2937WAYNE, NJ
  • Regorafenib (BAY 73-4506)
  • 4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide
  • 4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
  • regorafinib
  • Regafenib
  • Reggae sorafenib
  • Regorafenib C3X-1410
  • Regorafenib, >=98%
  • 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
  • Fluoro-Sorafenib
  • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Regorafenib BAY 73-4506
  • Stivarga(regorafenib)
  • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
  • 842-2937WAYNE
  • China Hot sale Regorafenib with best price and high quality CAS NO.755037-03-7
  • CS-1930
  • Regorafenib - BAY 73-4506 | Stivarga
  • CS-169
  • Regorafenib (BAY73-4506,Fluoro-Sorafenib)
  • REGORAFENIB; BAY 73-4506; SORAFENIB; BAY-73-4506; BAY 73 4506
  • Regorafenib(W.S)
  • Re orafenib
  • 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
  • レゴラフェニブ
Copyright 2017 © ChemicalBook. All rights reserved