ChemicalBook
Chinese english Germany Korea

(1-アダマンチル)アミン

(1-アダマンチル)アミン 化学構造式
768-94-5
CAS番号.
768-94-5
化学名:
(1-アダマンチル)アミン
别名:
(1-アダマンチル)アミン;1-アミノアダマンタン;トリシクロ[3.3.1.13,7]デカン-1-アミン;アダマントアミン;1-アダマンチルアミン;アダマンチルアミン;アマンタジン;アダマンタン-1-アミン;1-アダマントアミン;アダマンタンアミン;アマンチジン;1-アダマンタンアミン;1アミノアダマンタン;1-アダマンタンアミン (昇華精製品);1-アダマンタナミン;アダマンタンアミン, 1-
英語化学名:
Amantadine
英語别名:
C06818;Amanta;Pk-Merz;Symadine;Amantadin;Mantadine;NSC 341865;AMANTADINE;Amantidine;AMANTADINA
CBNumber:
CB3259991
化学式:
C10H17N
分子量:
151.25
MOL File:
768-94-5.mol

(1-アダマンチル)アミン 物理性質

融点 :
206-208 °C(lit.)
沸点 :
263.29°C (rough estimate)
比重(密度) :
0.9510 (rough estimate)
屈折率 :
1.5220 (estimate)
溶解性:
1 M HCl: soluble5%, clear to hazy, colorless to faint yellow or tan
外見 :
Powder
酸解離定数(Pka):
10.1(at 25℃)
色:
White to cream
水溶解度 :
Soluble in organic solvents. Insoluble in water.
Merck :
14,374
BRN :
2204333
InChIKey:
DKNWSYNQZKUICI-UHFFFAOYSA-N
CAS データベース:
768-94-5(CAS DataBase Reference)
NISTの化学物質情報:
Tricyclo[3.3.1.13,7]decane-1-amine(768-94-5)
EPAの化学物質情報:
Tricyclo[3.3.1.13, 7]decan-1-amine(768-94-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,Xi
Rフレーズ  22-36/37/38
Sフレーズ  26-36
WGK Germany  3
RTECS 番号 YD1925000
10-34
HSコード  29213000
有毒物質データの 768-94-5(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P405 施錠して保管すること。

(1-アダマンチル)アミン 価格 もっと(24)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01APOOR14310 1-アミノアダマンタン
1-Aminoadamantane
768-94-5 25g ¥15400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01APOOR14310 1-アミノアダマンタン
1-Aminoadamantane
768-94-5 100g ¥39600 2018-12-26 購入
東京化成工業 A2318 1-アダマンタンアミン >98.0%(GC)(T)
1-Adamantanamine >98.0%(GC)(T)
768-94-5 5g ¥7300 2018-12-04 購入
東京化成工業 A2318 1-アダマンタンアミン >98.0%(GC)(T)
1-Adamantanamine >98.0%(GC)(T)
768-94-5 25g ¥23700 2018-12-04 購入
Sigma-Aldrich Japan 138576 1-アダマンチルアミン 97%
1-Adamantylamine 97%
768-94-5 5g ¥6500 2018-12-25 購入

(1-アダマンチル)アミン MSDS


Amantadine

(1-アダマンチル)アミン 化学特性,用途語,生産方法

外観

白色~うすい黄褐色、結晶性粉末~粉末

用途

アマンタジン (Amantadine) は、アダマンタンにアミノ基がついた構造をしているアミンの一種である。NMDA受容体を拮抗阻害作用がある。パーキンソン病やA型インフルエンザの治療に使われている。製品名はシンメトレル。

効能

抗ウイルス薬, M2タンパク阻害薬, パーキンソン病治療薬, ドパミン分泌促進薬

化学的特性

White to cream powder

使用

Building block for an L-piperidinamide catalyst used in an enantioselective Strecker reaction of phosphinoyl imines.1

定義

ChEBI: A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.

brand name

Symadine (Solvay Pharmaceuticals); Symmetrel (Endo).

生物学の機能

Amantadine was originally introduced as an antiviral compound, but it is modestly effective in treating symptoms of parkinsonism. It is useful in the early stages of parkinsonism or as an adjunct to levodopa therapy. Its mechanism of action in parkinsonism is not clear, but amantadine may affect dopamine release and reuptake. Additional sites of action may include antagonism at muscarinic and N-methyl-Daspartate (NMDA) receptors. Adverse effects include nausea, dizziness, insomnia, confusion, hallucinations, ankle edema, and livedo reticularis. Amantadine and the anticholinergics may exert additive effects on mental functioning

抗菌性

It inhibits influenza A virus replication at concentrations of 0.2– 0.6 mg/L, but has little or no activity against influenza B or C.

獲得抵抗性

Resistance is the consequence of mutations in amino acid positions 27, 30 and 31 in the M2 transmembrane sequence. Cross-resistance between amantadine and rimantadine is universal. Influenza H3N2 strains worldwide are now resistant, but seasonal H1N1 strains remain susceptible. Postexposure family prophylaxis results in the prompt emergence of drug resistance after onset of treatment.

一般的な説明

Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.

応用例(製薬)

A symmetrical synthetic C-10 tricyclic amine with an unusual cage-like structure, supplied as the hydrochloride for oral administration.

薬物動態学

Oral absorption: >90%
Cmax 200 mg oral per day: 0.4–0.9 mg/L after c. 4–6 h
Plasma half-life: 9.7–14.5 h
Volume of distribution: 10.4 L/kg
Plasma protein binding: 65%
Absorption and distribution
Absorption after oral administration is almost complete. Levels in secretions approach plasma concentrations.
Metabolism and excretion
About 56% of a single oral dose is excreted unchanged within 24 h by the kidney. Altogether 90% of an oral dose is excreted in the urine with a mean elimination half-life of 11.8 h in subjects with normal renal function. In elderly men, the half-life is 28.9 h and in patients with renal insufficiency half-lives of 18.5 h to 33.8 days have been observed. The renal clearance is around 398 mL/min (range 112–772 mL/min), indicating active secretion as well as glomerular filtration. Less than 5% of a dose is removed during hemodialysis and average half-lives of 8.3 and 13 days have been reported in patients on chronic hemodialysis. Extreme care must be taken to ensure that drug does not accumulate to toxic levels.

臨床応用

Prevention and treatment of influenza A H1N1 infections

臨床応用

Amantadine is used for the treatment of diseases caused by influenza A strains.

副作用

Embryotoxicity and teratogenicity have been observed in rats receiving 50 mg/kg per day, about 15 times the usual human dose. Neurological side effects include drowsiness, insomnia, light-headedness, difficulty in concentration, nervousness, dizziness and headache in up to 20% of individuals. Other side effects include anorexia, nausea, vomiting, dry mouth, constipation and urinary retention. All develop during the first 3–4 days of therapy and are reversible by discontinuing the drug. An exception to rapid onset of adverse reactions is livedo reticularis. Convulsions, hallucinations and confusion are dose related, usually occurring at levels in excess of 1.5 mg/L; convulsions may occur at a lower threshold in patients with a history of epilepsy and the drug is best avoided in such patients.

純化方法

Dissolve the amine in Et2O, dry it over KOH, evaporate and sublime it in vacuo. [Stetter et al. Chem Ber 93 226 1960.]

(1-アダマンチル)アミン 上流と下流の製品情報

原材料

準備製品


(1-アダマンチル)アミン 生産企業

Global( 239)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23958 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Standardpharm Co. Ltd.
0714-3992388
yxzy@std-med.net CHINA 11847 58
SICHUAN ZHONGBANG TECHNICAL DEVELOPING LIMITED COMPANY +86-830-2585019
+86-830-2589033 info@zhongbangst.com China 99 69

768-94-5((1-アダマンチル)アミン)キーワード:


  • 768-94-5
  • Tricyclo[3.3.1.1(3,7)]decan-1-amine
  • tricyclo[3.3.1.13,7]decan-1-amine
  • Symadine
  • adamantan-1-amine
  • AMANTADINE HCL USP(CRM STANDARD)
  • AmantadineHclUsp27
  • 1-Adamantylamine (base and/or unspecified salts)
  • AMANTADINEBASE
  • 1-Adamantanamine (6CI, 8CI)
  • NSC 341865
  • 1-ADAMANTAMINE (1-AMINOADAMANTANE)
  • C06818
  • Amantadine Sulfate & Amantadine
  • ADAMANTANAMINE, 1-(SG)
  • 1-Aminoadamantane 98%
  • 1-ADAMANTYLAMINE
  • 1-ADAMANTANAMINE
  • 1-ADAMANTAMINE
  • 1-AMINOADAMANTANE
  • ADAMANTANAMINE
  • AMANTADINE
  • tricyclo[3.3.1.1(3,7)]decane-1-amine
  • 1-Adamantanamin
  • 1-Amantadine
  • 1-Adamantylamine,1-Aminoadamantane
  • AdaMantanone aMine
  • 1-AMinoadaMantane--d6
  • (3s,5s,7s)-adaMantan-1-aMine
  • AMantadine - Recordati
  • 1-Aminoadamantane, tech
  • (1-アダマンチル)アミン
  • 1-アミノアダマンタン
  • トリシクロ[3.3.1.13,7]デカン-1-アミン
  • アダマントアミン
  • 1-アダマンチルアミン
  • アダマンチルアミン
  • アマンタジン
  • アダマンタン-1-アミン
  • 1-アダマントアミン
  • アダマンタンアミン
  • アマンチジン
  • 1-アダマンタンアミン
  • 1アミノアダマンタン
  • 1-アダマンタンアミン (昇華精製品)
  • 1-アダマンタナミン
  • アダマンタンアミン, 1-
  • Parkinson病治療薬
  • ドーパミン作動薬
  • 代謝産物
  • 抗ウイルス薬
  • 脳代謝賦活薬
Copyright 2017 © ChemicalBook. All rights reserved