プレカナチド

プレカナチド 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

プレカナチド 化学特性,用途語,生産方法

使用

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

酵素阻害剤

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

プレカナチド 上流と下流の製品情報

原材料

準備製品

プレカナチド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Apextide Co Ltd	+undefined15700198315	senjie.hou@sinopep.com	China	71	58
Shanghai Chinqesen Biotechnology Co., Ltd.	+86-16628886292 +86-19521323435	sales2@qschem-pharma.com	China	46	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	265	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Shanghai Getian Industrial Co., LTD	+undefined15373193816	mike@ge-tian.com	China	272	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55

467426-54-6(プレカナチド)キーワード:

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• 467426-54-6
• Plecanatide
• ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4)
• Plecanatide Impurtiy
• L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
• Plecanatide impurity
• Plecanatide USP/EP/BP
• Prikanatide
• ATCH(1-39)
• Trulance
• (4S)-4-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-carboxypropanamido]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(carbamoylmethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-bis(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl]carbamoyl}butanoic acid
• Pukanatide
• プレカナチド
• (4S)-4-[(2S)-2-[(2S)-2-アミノ-3-カルバモイルプロパンアミド]-3-カルボキシプロパンアミド]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(カルバモイルメチル)-38-{[(1S)-1-カルボキシ-3-メチルブチル]カルバモイル}-22-(2-カルボキシエチル)-32-[(1R)-1-ヒドロキシエチル]-4-メチル-19-(2-メチルプロピル)-3,6,9,12,15,18,21,24,30,33,36-ウンデカオキソ-7,13-ビス(プロパン-2-イル)-27,28,40,41-テトラチア-2,5,8,11,14,17,20,23,31,34,37-ウンデカアザビシクロ[14.13.13]ドテトラコンタン-25-イル]カルバモイル}ブタン酸