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レバミソール

レバミソール 化学構造式
14769-73-4
CAS番号.
14769-73-4
化学名:
レバミソール
别名:
レバミソール;レバミゾール;ケトラックス;レボミソール;1-テトラミソール;(6S)-2,3,5,6-テトラヒドロ-6-フェニルイミダゾ[2,1-b]チアゾール;レプロン;(6S)-2,3,5,6-テトラヒドロ-6α-フェニルイミダゾ[2,1-b]チアゾール;(-)-レバミソール;ベルミソール150;L-テトラミソール;(-)-テトラミソール;(6S)-6α-フェニル-2,3,5,6-テトラヒドロイミダゾ[2,1-b]チアゾール;レバミゾ-ル;(S)2,3,5,6テトラヒドロ6フェニルイミダゾ[2,1b]チアゾル
英語化学名:
Levamisole
英語别名:
Ketrax;lepuron;levomysol;LEVAMISOLE;l-tetramisole;LEVAMISOLE BASE;Levamisole powder;(S)-(-)-Levamisole;levamisole +8619930501651;IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR
CBNumber:
CB3335709
化学式:
C11H12N2S
分子量:
204.29
MOL File:
14769-73-4.mol

レバミソール 物理性質

融点 :
60-61.5°
比旋光度 :
D25 -85.1° (c = 10 in chloroform)
貯蔵温度 :
0-6°C
CAS データベース:
14769-73-4(CAS DataBase Reference)
EPAの化学物質情報:
Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-(14769-73-4)

安全性情報

レバミソール 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

レバミソール 化学特性,用途語,生産方法

用途

レバミゾール(levamisole)とは線虫駆虫薬の1種。線虫の体内におけるフマル酸の還元およびコハク酸の酸化を遮断することにより炭水化物代謝を抑制し、駆虫効果を発揮する。 レバミゾールは小腸、胎盤型を除くほとんどのアルカリホスファターゼアイソフォームを可逆的?非競合的に阻害する。このため、in situ ハイブリダイゼーションやウェスタンブロッティングなどを用いたシグナル検出において、余分なアルカリホスファターゼ活性を減らすための抑制剤として使用される。

効能

駆虫薬

使用

Biological response modifier.

定義

ChEBI: A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in huma s as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.

適応症

Levamisole (Ergamisol) is an antiparasitic drug that has been found to enhance T-cell function and cellular immunity. The drug improves survival of patients with resected colorectal cancers when combined with 5-fluorouracil; the mechanism of this interaction is not known. Levamisole does not have antitumor activity against established or metastatic cancer and has not been found useful in the adjuvant therapy of cancers other than colorectal cancer.
The major adverse effects of levamisole are nausea and anorexia. Skin rashes, itching, flulike symptoms, and fevers also have been observed.

適応症

Levamisole (Ergamisol) was originally developed as an antihelminthic drug. It potentiates the stimulatory effects of antigens, mitogens, lymphokines, and chemotactic factors on lymphocytes, granulocytes, and macrophages. It has been shown to increase T cell–mediated immunity.
Levamisole has been used successfully in treating chronic infections. It also has been approved for use in combination with fluorouracil in the treatment of colorectal cancer.

brand name

Ergamisol (Janssen).

抗菌性

Its principal activity is against Asc. lumbricoides and hookworms. Worms are paralyzed and passed out in the feces within a few hours.

応用例(製薬)

The l-isomer of tetramisole, available as the monohydrochloride. The d-isomer has no anthelmintic activity. It is very soluble in water and is stable in the dry state.

薬物動態学

Oral absorption: c. 90%
Cmax 150 mg oral: 0.5 mg/L after c. 2 h
Plasma half-life: c. 4 h
Volume of distribution: 100–120 L
Levamisole is rapidly absorbed from the gut and extensively metabolized in the liver. It is excreted chiefly in the urine.

臨床応用

Ascariasis
Hookworm infection
Levamisole has been used in rheumatoid arthritis and some other conditions that are said to respond to its immunomodulatory activity.

副作用

Nausea, gastrointestinal upsets and very mild neurological problems have been reported.

Veterinary Drugs and Treatments

Depending on the product licensed, levamisole is indicated for the treatment of many nematodes in cattle, sheep and goats, swine, poultry. In sheep and cattle, levamisole has relatively good activity against abomasal nematodes, small intestinal nematodes (not particularly good against Strongyloides spp.), large intestinal nematodes (not Trichuris spp.), and lungworms. Adult forms of species that are usually covered by levamisole, include: Haemonchus spp., Trichostrongylus spp., Osteragia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., and Dictyocaulus vivapurus. Levamisole is less effective against the immature forms of these parasites, and is generally ineffective in cattle (but not sheep) against arrested larval forms. Resistance of parasites to levamisole is a growing concern.
In swine, levamisole is indicated for the treatment of Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, and Metastrongylus.
Levamisole has been used in dogs as a microfilaricide to treat Dirofilaria immitis infection in the past, but is rarely used today. It has also garnered some interest as an immunostimulant in the adjunctive therapy of various neoplasms.
Because of its narrow margin for safety and limited efficacy against many equine parasites, levamisole is not generally used in horses as an antiparasitic agent. It has been tried as an immune stimulant, however.

レバミソール 上流と下流の製品情報

原材料

準備製品


レバミソール 生産企業

Global( 92)Suppliers
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14769-73-4(レバミソール)キーワード:


  • 14769-73-4
  • levamisole +8619930501651
  • (s)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole
  • L-6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZOL(2,1-B) THIAZOLE
  • IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR
  • LEVAMISOLE
  • LEVAMISOLE BASE
  • Imidazo2,1-bthiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-
  • lepuron
  • levomysol
  • l-tetramisole
  • 6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZO[2,1-B]THIAZOLE (LEVAMISOLE)
  • (6S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole
  • Ketrax
  • (S)-6-phenyl-2,3,5,6-tetrahydroiMidazo[2,1-b]thiazole
  • (S)-(-)-Levamisole
  • Tetramisole cas 14769-73-4 (skype:lisa_21819)
  • Levamisole powder
  • Tetramisole cas 14769-73-4 (whatsapp:+8618830163278)
  • レバミソール
  • レバミゾール
  • ケトラックス
  • レボミソール
  • 1-テトラミソール
  • (6S)-2,3,5,6-テトラヒドロ-6-フェニルイミダゾ[2,1-b]チアゾール
  • レプロン
  • (6S)-2,3,5,6-テトラヒドロ-6α-フェニルイミダゾ[2,1-b]チアゾール
  • (-)-レバミソール
  • ベルミソール150
  • L-テトラミソール
  • (-)-テトラミソール
  • (6S)-6α-フェニル-2,3,5,6-テトラヒドロイミダゾ[2,1-b]チアゾール
  • レバミゾ-ル
  • (S)2,3,5,6テトラヒドロ6フェニルイミダゾ[2,1b]チアゾル
  • 免疫賦活薬
  • 駆虫薬
  • 殺線虫剤
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