N-〔2-(メチルアミノ)エチル〕-5-イソキノリンスルホアミド二塩酸塩 化学特性,用途語,生産方法
説明
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-
8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with K
i values of 1.2, 0.48, 15, and 68 μM, respectively. H-
8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC
50 values of 47 and 6.2 μM, respectively.
化学的特性
white to off-white crystalline solid
使用
Active inhibitor of cyclic-nucleotide-dependent protein kinases.
N-〔2-(メチルアミノ)エチル〕-5-イソキノリンスルホアミド二塩酸塩 上流と下流の製品情報
原材料
準備製品