K-252B

K-252B 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01CAY11339	K252b	99570-78-2	500μg	￥54600	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CAY11339	K252b	99570-78-2	1mg	￥93800	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTK0022	K252b	99570-78-2	100μg	￥34800	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTK0022	K252b	99570-78-2	1mg	￥150800	2024-03-01	購入

K-252B 化学特性,用途語,生産方法

説明

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC₅₀ = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.

化学的特性

Yellow solid

使用

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

K-252B 上流と下流の製品情報

原材料

準備製品

K-252B 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 13675144456	sean.lv@synzest.com	China	11442	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 18521732826;	market@aladdin-e.com	China	24827	65
TargetMol Chemicals Inc.	021-33632979 15002134094	marketing@targetmol.com	China	7934	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

99570-78-2(K-252B)キーワード:

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• 99570-78-2
• PROTEIN KINASE INHIBITOR K-252B
• K-252B
• K-252B, NOCARDIOPSIS SP
• K-252B, NOCARDIOPSIS SPECIES
• K252B READY MADE
• k-252b solution
• Antibiotic K 252b
• KT 5556
• K252b Antibiotic K 252b KT 5556
• (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-
• (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid
• K-252B
• (9S)-2,3,9,10,11,12-ヘキサヒドロ-10β-ヒドロキシ-9-メチル-1-オキソ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3′,2′,1′-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10-カルボン酸
• (15S,16S,18R)-16-ヒドロキシ-15-メチル-3-オキソ-28-オキサ-4,14,19-トリアザオクタシクロ[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]オクタコサ-1(26),2(6),7(27),8,10,12,20(25),21,23-ノナエン-16-カルボン酸